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    Ttf2 transcription termination factor, RNA polymerase II [ Mus musculus (house mouse) ]

    Gene ID: 74044, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ttf2provided by MGI
    Official Full Name
    transcription termination factor, RNA polymerase IIprovided by MGI
    Primary source
    MGI:MGI:1921294
    See related
    Ensembl:ENSMUSG00000033222 AllianceGenome:MGI:1921294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8030447N19; 4632434F22Rik
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA. Predicted to act upstream of or within DNA-templated transcription, termination; RNA splicing; and mRNA processing. Predicted to be located in cytosol. Predicted to be part of spliceosomal complex. Is expressed in olfactory cortex ventricular layer and telencephalon ventricular layer. Orthologous to human TTF2 (transcription termination factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.9), limb E14.5 (RPKM 4.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F2.2; 3 43.86 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100846176..100877016, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (100938860..100969700, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E232 Neighboring gene predicted gene, 40108 Neighboring gene tripartite motif-containing 45 Neighboring gene STARR-positive B cell enhancer ABC_E2678 Neighboring gene CD101 antigen Neighboring gene STARR-seq mESC enhancer starr_08505 Neighboring gene prostaglandin F2 receptor negative regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells. Cederbaum AI. J Gastroenterol Hepatol, 2006 Oct. PMID 16958665
    2. Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Penha-Gonçalves C, et al. Diabetes, 2003 Jun. PMID 12765969
    3. Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Tiozzo C, et al. Endocr Relat Cancer, 2012 Apr. PMID 22167068, Free PMC Article
    4. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542, Free PMC Article
    5. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA-templated transcription termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription termination factor 2
    Names
    RNA polymerase II termination factor
    transcription release factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013026.2 → NP_001013044.2  transcription termination factor 2

      See identical proteins and their annotated locations for NP_001013044.2

      Status: VALIDATED

      Source sequence(s)
      AK087352, BC087733, BC096625
      Consensus CDS
      CCDS17679.1
      UniProtKB/Swiss-Prot
      Q4V9Y7, Q5M924, Q5NC05
      Related
      ENSMUSP00000076208.6, ENSMUST00000076941.12
      Conserved Domains (5) summary
      cd00046
      Location:566 → 744
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:549 → 909
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:966 → 1082
      Helicase_C; Helicase conserved C-terminal domain
      pfam06839
      Location:4 → 44
      zf-GRF; GRF zinc finger
      pfam10243
      Location:132 → 464
      MIP-T3; Microtubule-binding protein MIP-T3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      100846176..100877016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163360.1 → XP_036019253.1  transcription termination factor 2 isoform X2

      Conserved Domains (4) summary
      PHA03169
      Location:149 → 325
      PHA03169; hypothetical protein; Provisional
      COG0553
      Location:546 → 1133
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18072
      Location:543 → 793
      DEXHc_TTF2; DEAH-box helicase domain of TTF2
      pfam06839
      Location:4 → 44
      zf-GRF; GRF zinc finger

    2. XM_036163359.1 → XP_036019252.1  transcription termination factor 2 isoform X1

      Conserved Domains (3) summary
      COG0553
      Location:566 → 1153
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18072
      Location:563 → 813
      DEXHc_TTF2; DEAH-box helicase domain of TTF2
      pfam06839
      Location:4 → 44
      zf-GRF; GRF zinc finger

    3. XM_036163361.1 → XP_036019254.1  transcription termination factor 2 isoform X3

      Conserved Domains (3) summary
      COG0553
      Location:566 → 1107
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18072
      Location:563 → 813
      DEXHc_TTF2; DEAH-box helicase domain of TTF2
      pfam06839
      Location:4 → 44
      zf-GRF; GRF zinc finger

    RNA

    1. XR_375588.3 RNA Sequence

    2. XR_004941407.1 RNA Sequence

    3. XR_004941408.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NC05.2 GenPept UniProtKB/Swiss-Prot:Q5NC05

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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