Rpl22 ribosomal protein L22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rpl22provided by MGI
Official Full Name: ribosomal protein L22provided by MGI
Primary source: MGI:MGI:99262
See related: Ensembl:ENSMUSG00000028936 AllianceGenome:MGI:99262
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2700038K18Rik
Summary: Enables heparin binding activity and translation regulator activity. Involved in regulation of translation at presynapse, modulating synaptic transmission. Acts upstream of or within alpha-beta T cell differentiation. Located in glutamatergic synapse; presynapse; and ribosome. Orthologous to human RPL22 (ribosomal protein L22). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 82.1), bladder adult (RPKM 62.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 83.03 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (152408893..152418539)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (152324436..152334082)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RPL22 Overexpression Promotes Psoriasis-Like Lesion by Inducing Keratinocytes Abnormal Biological Behavior.
Title: RPL22 Overexpression Promotes Psoriasis-Like Lesion by Inducing Keratinocytes Abnormal Biological Behavior.
Rpl22, and its highly homologous paralog Rpl22-Like1 (Rpl22l1 or Like1) play critical, extraribosomal roles in embryogenesis.
Title: Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.
finding that Rpl22 deficiency exacerbates endoplasmic reticulum stress responses and induces p53 in alphabeta T cell progenitors provides insight into how a ubiquitously expressed RP can perform regulatory functions that are selectively required by some cell lineages but not others
Title: Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling.
RPL22 underexpression is associated with Dissemination of T-cell Lymphoma.
Title: Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma.
Rpl22 performs a critical, developmentally restricted role in supporting early B cell development by preventing p53 induction.
Title: Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint.
either ribosomal protein can support translation, knockdown of Rpl22l1 impairs growth of cells lacking Rpl22. Mechanistically, Rpl22 regulates Rpl22l1 directly by binding to an internal hairpin structure and repressing its expression
Title: The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.
Rpl22 inactivation promotes neoplastic transformation by inducing expression of Lin28B
Title: Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.
Investigation of downstream effectors used by tumor protein p53 to impair T cell lineage development finds many p53 targets are induced in Rpl22-deficient thymocytes, including miR-34a, PUMA, p21waf, Bax, and Noxa.
Title: Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors.
Rpl22 deficiency activated a p53-dependent checkpoint that produced a remarkably selective block in alphabeta T cell development.
Title: Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW821988 (e-PCR)
- UniSTS:207731

AW821993 (e-PCR)
- UniSTS:207734

AW743286 (e-PCR)
- UniSTS:207735

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translation at postsynapse	NAS Non-traceable Author Statement more info	PubMed
involved_in translation at presynapse	IDA Inferred from Direct Assay more info	PubMed
involved_in translation at presynapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic large ribosomal subunit	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in ribosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in ribosome	IMP Inferred from Mutant Phenotype more info	PubMed
located_in ribosome	ISO Inferred from Sequence Orthology more info
located_in ribosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in ribosome	NAS Non-traceable Author Statement more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: large ribosomal subunit protein eL22

Names: 60S ribosomal protein L22; heparin-binding protein HBp15

NP_001264042.1

EC 2.1.1.100

NP_001264043.1

EC 2.1.1.100

NP_033105.1

EC 2.1.1.100

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277113.1 → NP_001264042.1 large ribosomal subunit protein eL22 isoform b

Status: VALIDATED

Source sequence(s)

AL611985

Conserved Domains (1) summary

pfam01776
Location:39 → 142

Ribosomal_L22e; Ribosomal L22e protein family
NM_001277114.2 → NP_001264043.1 large ribosomal subunit protein eL22 isoform c

Status: VALIDATED

Source sequence(s)

AL611985

Conserved Domains (1) summary

pfam01776
Location:16 → 80

Ribosomal_L22e; Ribosomal L22e protein family
NM_009079.4 → NP_033105.1 large ribosomal subunit protein eL22 isoform a

See identical proteins and their annotated locations for NP_033105.1

Status: VALIDATED

Source sequence(s)

AL611985

Consensus CDS

CCDS18999.1

UniProtKB/Swiss-Prot

P67984

UniProtKB/TrEMBL

Q4VAG4

Related

ENSMUSP00000118787.2, ENSMUST00000139685.8

Conserved Domains (1) summary

pfam01776
Location:21 → 119

Ribosomal_L22e; Ribosomal L22e protein family