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    Csrnp3 cysteine-serine-rich nuclear protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 77771, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Csrnp3provided by MGI
    Official Full Name
    cysteine-serine-rich nuclear protein 3provided by MGI
    Primary source
    MGI:MGI:1925021
    See related
    Ensembl:ENSMUSG00000044647 AllianceGenome:MGI:1925021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mbu1; Csnrp3; taip-2; CSRNP-3; A330102K23Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of apoptotic process and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; gonad; intestine; liver; and lung. Orthologous to human CSRNP3 (cysteine and serine rich nuclear protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 9.1), whole brain E14.5 (RPKM 8.2) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C1.3; 2 38.79 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (65675628..65866958)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (65845284..66036614)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm777 Neighboring gene sodium channel, voltage-gated, type II, alpha Neighboring gene STARR-seq mESC enhancer starr_04691 Neighboring gene STARR-seq mESC enhancer starr_04692 Neighboring gene STARR-seq mESC enhancer starr_04693 Neighboring gene predicted gene, 51432 Neighboring gene predicted gene, 52514 Neighboring gene STARR-seq mESC enhancer starr_04694 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_04695 Neighboring gene tetratricopeptide repeat domain 21B Neighboring gene STARR-positive B cell enhancer mm9_chr2:66094546-66094847

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential promoter methylation and histone modification contribute to the brain specific expression of the mouse Mbu-1 gene. Kim B, et al. Mol Cells, 2012 Nov. PMID 23076708, Free PMC Article
    2. Characterization of a novel mouse brain gene (mbu-1) identified by digital differential display. Yang HL, et al. Gene, 2007 Jun 15. PMID 17433858
    3. Taip2 is a novel cell death-related gene expressed in the brain during development. Yamada K, et al. Biochem Biophys Res Commun, 2008 May 2. PMID 18291095
    4. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). Gingras S, et al. PLoS One, 2007 Aug 29. PMID 17726538, Free PMC Article
    5. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CpG methylation converses with histone modifications in an opposing sense of regulating Mbu-1 expression
      Title: Differential promoter methylation and histone modification contribute to the brain specific expression of the mouse Mbu-1 gene.
    2. the mbu-1 gene was only expressed in the brain and spinal cord during the embryonic stages, and throughout all regions of the adult brain, showing higher levels in the hippocampus and hypothalamus
      Title: Characterization of a novel mouse brain gene (mbu-1) identified by digital differential display.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine/serine-rich nuclear protein 3
    Names
    TGF-beta induced apoptosis protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290665.1 → NP_001277594.1  cysteine/serine-rich nuclear protein 3 isoform b

      See identical proteins and their annotated locations for NP_001277594.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK158873, AL929230, AW492062
      Consensus CDS
      CCDS71060.1
      UniProtKB/Swiss-Prot
      P59055
      Related
      ENSMUSP00000135605.2, ENSMUST00000145598.9
      Conserved Domains (1) summary
      pfam16019
      Location:61 → 278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    2. NM_001290666.1 → NP_001277595.1  cysteine/serine-rich nuclear protein 3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons, and it thus differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AL929230, AW492062, BC055701, BY297754
      UniProtKB/TrEMBL
      Q7TNU4
      Conserved Domains (2) summary
      pfam16019
      Location:35 → 180
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
      cl00310
      Location:371 → 416
      AIRC; AIR carboxylase

    3. NM_153409.5 → NP_700458.3  cysteine/serine-rich nuclear protein 3 isoform a

      See identical proteins and their annotated locations for NP_700458.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
      Source sequence(s)
      AK039150, AL929230, BY297754, EF210820
      Consensus CDS
      CCDS16074.2
      UniProtKB/Swiss-Prot
      A3F6Q4, P59055, Q8BUT9, Q8BYL1
      Related
      ENSMUSP00000117533.2, ENSMUST00000122912.8
      Conserved Domains (1) summary
      pfam16019
      Location:73 → 290
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    4. NM_178634.2 → NP_848749.2  cysteine/serine-rich nuclear protein 3 isoform a

      See identical proteins and their annotated locations for NP_848749.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK082649, AL929230, BY297754, EF210820
      Consensus CDS
      CCDS16074.2
      UniProtKB/Swiss-Prot
      A3F6Q4, P59055, Q8BUT9, Q8BYL1
      Related
      ENSMUSP00000055719.4, ENSMUST00000053910.10
      Conserved Domains (1) summary
      pfam16019
      Location:73 → 290
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      65675628..65866958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252233.1 → XP_030108093.1  cysteine/serine-rich nuclear protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A3F6Q4, P59055, Q8BUT9, Q8BYL1
      Conserved Domains (1) summary
      pfam16019
      Location:73 → 290
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    2. XM_030252234.1 → XP_030108094.1  cysteine/serine-rich nuclear protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A3F6Q4, P59055, Q8BUT9, Q8BYL1
      Conserved Domains (1) summary
      pfam16019
      Location:73 → 290
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    3. XM_030252235.1 → XP_030108095.1  cysteine/serine-rich nuclear protein 3 isoform X2

      Conserved Domains (1) summary
      pfam16019
      Location:61 → 278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    4. XM_036162720.1 → XP_036018613.1  cysteine/serine-rich nuclear protein 3 isoform X2

      Conserved Domains (1) summary
      pfam16019
      Location:61 → 278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    5. XM_030252237.1 → XP_030108097.1  cysteine/serine-rich nuclear protein 3 isoform X2

      Conserved Domains (1) summary
      pfam16019
      Location:61 → 278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    6. XM_030252236.1 → XP_030108096.1  cysteine/serine-rich nuclear protein 3 isoform X2

      Conserved Domains (1) summary
      pfam16019
      Location:61 → 278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59055.2 GenPept UniProtKB/Swiss-Prot:P59055

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