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    Mgll monoglyceride lipase [ Mus musculus (house mouse) ]

    Gene ID: 23945, updated on 28-Jun-2021

    Summary

    Official Symbol
    Mgllprovided by MGI
    Official Full Name
    monoglyceride lipaseprovided by MGI
    Primary source
    MGI:MGI:1346042
    See related
    Ensembl:ENSMUSG00000033174
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ma; Mgl; Magl; AA589436
    Summary
    This gene encodes a monoglyceride lipase, which catalyzes the hydrolysis of monoglycerides into fatty acids and glycerol. This enzyme is also thought to hydrolyze the endocannabinoid 2-arachidonoylglycerol. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 221.3), genital fat pad adult (RPKM 144.9) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mgll in Genome Data Viewer
    Location:
    6; 6 D1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88701381..88805342)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88724412..88828360)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (88674406..88778354)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Sec61 alpha 1 subunit (S. cerevisiae) Neighboring gene kelch repeat and BTB (POZ) domain containing 12 Neighboring gene predicted gene, 26588 Neighboring gene predicted gene 15612 Neighboring gene ankyrin repeat and BTB (POZ) domain containing 1 Neighboring gene podocalyxin-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables acylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acylglycerol lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables acylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in acylglycerol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in acylglycerol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in acylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in arachidonic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoacylglycerol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monoacylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of endocannabinoid signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in varicosity IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    monoglyceride lipase
    Names
    monoacylglycerol lipase
    NP_001159721.1
    NP_001159722.1
    NP_001159723.1
    NP_035974.1
    XP_036021993.1
    XP_036021994.1
    XP_036021995.1
    XP_036021996.1
    XP_036021997.1
    XP_036021998.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166249.1NP_001159721.1  monoglyceride lipase isoform c

      See identical proteins and their annotated locations for NP_001159721.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AA822246, AK131645, AK136867, AK148395, BY273849, CX565913
      Consensus CDS
      CCDS51844.1
      UniProtKB/Swiss-Prot
      O35678
      UniProtKB/TrEMBL
      Q3UFN1
      Related
      ENSMUSP00000109212.2, ENSMUST00000113582.8
      Conserved Domains (2) summary
      pfam12146
      Location:41230
      Hydrolase_4; Serine aminopeptidase, S33
      cl21494
      Location:22249
      Abhydrolase; alpha/beta hydrolases
    2. NM_001166250.1NP_001159722.1  monoglyceride lipase isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (d), which does not have in vivo support, has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC153860, AK006949, BY255454, BY706980
      UniProtKB/Swiss-Prot
      O35678
      Related
      ENSMUSP00000145068.2, ENSMUST00000150180.4
      Conserved Domains (1) summary
      cl21494
      Location:3893
      Abhydrolase; alpha/beta hydrolases
    3. NM_001166251.1NP_001159723.1  monoglyceride lipase isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AA822246, AC153860, AK006949, AK131645, AK136867, BY255454, BY706980, CX565913
      Consensus CDS
      CCDS51843.1
      UniProtKB/Swiss-Prot
      O35678
      UniProtKB/TrEMBL
      E9Q3B9
      Related
      ENSMUSP00000127374.2, ENSMUST00000163271.8
      Conserved Domains (2) summary
      pfam12146
      Location:57291
      Hydrolase_4; Serine aminopeptidase, S33
      cl21494
      Location:38310
      Abhydrolase; alpha/beta hydrolases
    4. NM_011844.4NP_035974.1  monoglyceride lipase isoform b

      See identical proteins and their annotated locations for NP_035974.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AA822246, AK131645, AK136867, BY273849, CX565913
      Consensus CDS
      CCDS20338.1
      UniProtKB/Swiss-Prot
      O35678
      Related
      ENSMUSP00000109215.3, ENSMUST00000113585.9
      Conserved Domains (2) summary
      pfam12146
      Location:41275
      Hydrolase_4; Serine aminopeptidase, S33
      cl21494
      Location:22294
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      88701381..88805342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166101.1XP_036021994.1  monoglyceride lipase isoform X2

      Related
      ENSMUSP00000109211.2, ENSMUST00000113581.8
      Conserved Domains (1) summary
      cl21494
      Location:22322
      Abhydrolase; alpha/beta hydrolases
    2. XM_036166100.1XP_036021993.1  monoglyceride lipase isoform X1

      Conserved Domains (1) summary
      cl21494
      Location:38338
      Abhydrolase; alpha/beta hydrolases
    3. XM_036166104.1XP_036021997.1  monoglyceride lipase isoform X5

      Conserved Domains (1) summary
      cl21494
      Location:10262
      Abhydrolase; alpha/beta hydrolases
    4. XM_036166103.1XP_036021996.1  monoglyceride lipase isoform X4

      Conserved Domains (1) summary
      cl21494
      Location:10290
      Abhydrolase; alpha/beta hydrolases
    5. XM_036166105.1XP_036021998.1  monoglyceride lipase isoform X6

      Conserved Domains (1) summary
      cl21494
      Location:2231
      Abhydrolase; alpha/beta hydrolases
    6. XM_036166102.1XP_036021995.1  monoglyceride lipase isoform X3

      Conserved Domains (1) summary
      cl21494
      Location:13293
      Abhydrolase; alpha/beta hydrolases
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