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    Ly6k lymphocyte antigen 6 family member K [ Mus musculus (house mouse) ]

    Gene ID: 76486, updated on 5-Mar-2024

    Summary

    Official Symbol
    Ly6kprovided by MGI
    Official Full Name
    lymphocyte antigen 6 family member Kprovided by MGI
    Primary source
    MGI:MGI:1923736
    See related
    Ensembl:ENSMUSG00000044678 AllianceGenome:MGI:1923736
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mLy-6K; 2410015A16Rik; 3110035B01Rik
    Summary
    Acts upstream of or within binding activity of sperm to zona pellucida and flagellated sperm motility. Located in acrosomal vesicle; cell surface; and plasma membrane. Is expressed in several structures, including central nervous system; reproductive system; retina; spleen; and stomach. Orthologous to human LY6K (lymphocyte antigen 6 family member K). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 130.0), thymus adult (RPKM 15.7) and 1 other tissue See more
    Orthologs
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    Genomic context

    Location:
    15 D3; 15 34.28 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (74668723..74671817, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (74796874..74799968, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member G6G Neighboring gene STARR-seq mESC enhancer starr_38995 Neighboring gene predicted gene, 33174 Neighboring gene glycosylphosphatidylinositol anchored molecule like Neighboring gene STARR-seq mESC enhancer starr_38997 Neighboring gene glycosylphosphatidylinositol anchored molecule like 2 Neighboring gene cytochrome P450, family 11, subfamily b, polypeptide 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lymphocyte antigen 6K
    Names
    ly-6K
    lymphocyte antigen 6 complex, locus K

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029627.2NP_083903.1  lymphocyte antigen 6K precursor

      See identical proteins and their annotated locations for NP_083903.1

      Status: PROVISIONAL

      Source sequence(s)
      AK010485
      Consensus CDS
      CCDS27532.1
      UniProtKB/Swiss-Prot
      Q9CWP4
      Related
      ENSMUSP00000052599.6, ENSMUST00000060301.6
      Conserved Domains (1) summary
      cd00117
      Location:21109
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      74668723..74671817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)