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    Irf2bpl interferon regulatory factor 2 binding protein-like [ Mus musculus (house mouse) ]

    Gene ID: 238330, updated on 5-Mar-2024

    Summary

    Official Symbol
    Irf2bplprovided by MGI
    Official Full Name
    interferon regulatory factor 2 binding protein-likeprovided by MGI
    Primary source
    MGI:MGI:2442463
    See related
    Ensembl:ENSMUSG00000034168 AllianceGenome:MGI:2442463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eap1; 6430527G18Rik
    Summary
    Predicted to enable transcription corepressor activity and ubiquitin protein ligase activity. Predicted to be involved in development of secondary female sexual characteristics; nervous system development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human IRF2BPL (interferon regulatory factor 2 binding protein like). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    NEW
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    Genomic context

    Location:
    12 D2; 12 41.06 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (86927477..86931588, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (86880703..86884814, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51955 Neighboring gene STARR-positive B cell enhancer ABC_E5344 Neighboring gene predicted gene, 53734 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32848 Neighboring gene STARR-seq mESC enhancer starr_32850 Neighboring gene STARR-seq mESC enhancer starr_32852 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:88233078-88233265 Neighboring gene STARR-positive B cell enhancer ABC_E7164 Neighboring gene STARR-seq mESC enhancer starr_32856 Neighboring gene predicted gene, 26698 Neighboring gene predicted gene, 53735 Neighboring gene STARR-seq mESC enhancer starr_32861 Neighboring gene STARR-seq mESC enhancer starr_32863 Neighboring gene STARR-seq mESC enhancer starr_32864

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable E3 ubiquitin-protein ligase IRF2BPL
    Names
    enhanced at puberty protein 1
    polyglutamine-containing protein
    NP_665835.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145836.2NP_665835.1  probable E3 ubiquitin-protein ligase IRF2BPL

      See identical proteins and their annotated locations for NP_665835.1

      Status: VALIDATED

      Source sequence(s)
      AK173282
      Consensus CDS
      CCDS26068.1
      UniProtKB/Swiss-Prot
      Q3TBU9, Q3U483, Q3USE5, Q69Z84, Q8BUS1, Q8C011, Q8K3X4
      Related
      ENSMUSP00000041070.7, ENSMUST00000038422.8
      Conserved Domains (2) summary
      smart00184
      Location:694738
      RING; Ring finger
      pfam11261
      Location:1061
      IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      86927477..86931588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)