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    Mbp myelin basic protein [ Mus musculus (house mouse) ]

    Gene ID: 17196, updated on 29-May-2021

    Summary

    Official Symbol
    Mbpprovided by MGI
    Official Full Name
    myelin basic proteinprovided by MGI
    Primary source
    MGI:MGI:96925
    See related
    Ensembl:ENSMUSG00000041607
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    jv; Hmb; jve; mld; shi; goll; Hmbpr; C76307; R75289; golli-mbp
    Summary
    The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in cerebellum adult (RPKM 425.3), cortex adult (RPKM 253.5) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Mbp in Genome Data Viewer
    Location:
    18 E3; 18 55.84 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (82492883..82603762)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (82475091..82585637)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (82644515..82755029)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene galanin receptor 1 Neighboring gene ribosomal protein L21, pseudogene 8 Neighboring gene uncharacterized LOC118568383 Neighboring gene zinc finger protein 236 Neighboring gene predicted gene, 50351 Neighboring gene microRNA 5112

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in compact myelin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in compact myelin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in internode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in internode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myelin basic protein; Golli-Mbp
    Names
    myelin A1 protein
    myelin basic protein transcript variant X5
    myelin deficient
    shiverer

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025245.1NP_001020416.1  Golli-Mbp isoform 2

      See identical proteins and their annotated locations for NP_001020416.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains 3 exons unique to Golli-Mbp and exon 1 of the classic Mbp. It encodes the shorter of the Golli-Mbp isoforms (2).
      Source sequence(s)
      AC117825, AK039047, AK040716
      Consensus CDS
      CCDS29374.1
      UniProtKB/Swiss-Prot
      P04370
      UniProtKB/TrEMBL
      Q5D096
      Related
      ENSMUSP00000089393.5, ENSMUST00000091789.11
      Conserved Domains (1) summary
      pfam01669
      Location:147193
      Myelin_MBP; Myelin basic protein
    2. NM_001025251.2NP_001020422.1  myelin basic protein isoform 1

      See identical proteins and their annotated locations for NP_001020422.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest of the classic Mbp isoforms (1).
      Source sequence(s)
      AC119259, BF457157, BY245551, CO425201
      Consensus CDS
      CCDS29376.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000121855.3, ENSMUST00000123251.9
      Conserved Domains (1) summary
      pfam01669
      Location:14194
      Myelin_MBP; Myelin basic protein
    3. NM_001025254.2NP_001020425.1  myelin basic protein isoform 2

      See identical proteins and their annotated locations for NP_001020425.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks exon 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (2) that is missing a 11 aa segment compared to isoform 1.
      Source sequence(s)
      BB633793, BC004704
      Consensus CDS
      CCDS37875.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000114630.3, ENSMUST00000153478.9
      Conserved Domains (1) summary
      pfam01669
      Location:14183
      Myelin_MBP; Myelin basic protein
    4. NM_001025255.2NP_001020426.1  myelin basic protein isoform 3

      See identical proteins and their annotated locations for NP_001020426.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks exon 2 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (3) that is missing a 26 aa segment compared to isoform 1.
      Source sequence(s)
      AC119259, BY245551, CK623660
      Consensus CDS
      CCDS29377.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000115082.3, ENSMUST00000142850.9
      Conserved Domains (1) summary
      pfam01669
      Location:14168
      Myelin_MBP; Myelin basic protein
    5. NM_001025256.2NP_001020427.1  myelin basic protein isoform 4

      See identical proteins and their annotated locations for NP_001020427.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks exon 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (4) that is missing a 41 aa segment compared to isoform 1.
      Source sequence(s)
      AC119259, AK079621, BY245551
      Consensus CDS
      CCDS29378.1
      UniProtKB/Swiss-Prot
      P04370
      UniProtKB/TrEMBL
      Q542T4
      Related
      ENSMUSP00000115409.3, ENSMUST00000152071.9
      Conserved Domains (1) summary
      pfam01669
      Location:14148
      Myelin_MBP; Myelin basic protein
    6. NM_001025258.2NP_001020429.1  myelin basic protein isoform 5

      See identical proteins and their annotated locations for NP_001020429.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks exons 2 and 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (5) that is missing a 26 aa and a 11 aa segment compared to isoform 1.
      Source sequence(s)
      AC119259, BY245551, M15062
      Consensus CDS
      CCDS29379.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000114230.3, ENSMUST00000132369.3
      Conserved Domains (1) summary
      pfam01669
      Location:14157
      Myelin_MBP; Myelin basic protein
    7. NM_001025259.2NP_001020430.1  myelin basic protein isoform 6

      See identical proteins and their annotated locations for NP_001020430.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks exons 2 and 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (6) that is missing a 26 aa and a 41 aa segment compared to isoform 1.
      Source sequence(s)
      AC119259, AK005129, BY245551
      Consensus CDS
      CCDS89290.1
      UniProtKB/Swiss-Prot
      P04370
      UniProtKB/TrEMBL
      Q3UGF3
      Related
      ENSMUSP00000116019.3, ENSMUST00000133193.9
      Conserved Domains (1) summary
      pfam01669
      Location:14122
      Myelin_MBP; Myelin basic protein
    8. NM_010777.3NP_034907.1  Golli-Mbp isoform 1

      See identical proteins and their annotated locations for NP_034907.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains 3 exons unique to Golli-Mbp and exons 1, 3, 4 and 7 of the classic Mbp. It encodes the longer of the Golli-Mbp isoforms (1).
      Source sequence(s)
      AC117825, AC119259, L07507
      Consensus CDS
      CCDS29373.1
      UniProtKB/Swiss-Prot
      P04370
      Related
      ENSMUSP00000046185.8, ENSMUST00000047865.14
      Conserved Domains (1) summary
      pfam01669
      Location:147249
      Myelin_MBP; Myelin basic protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      82492883..82603762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526452.5XP_006526515.1  Golli-Mbp isoform X1

      Conserved Domains (1) summary
      pfam01669
      Location:147349
      Myelin_MBP; Myelin basic protein
    2. XM_006526455.3XP_006526518.1  Golli-Mbp isoform X5

      Conserved Domains (1) summary
      pfam01669
      Location:147308
      Myelin_MBP; Myelin basic protein
    3. XM_006526453.4XP_006526516.1  Golli-Mbp isoform X2

      Conserved Domains (1) summary
      pfam01669
      Location:147327
      Myelin_MBP; Myelin basic protein
    4. XM_006526457.4XP_006526520.1  Golli-Mbp isoform X8

      See identical proteins and their annotated locations for XP_006526520.1

      Conserved Domains (1) summary
      pfam01669
      Location:147274
      Myelin_MBP; Myelin basic protein
    5. XM_036161011.1XP_036016904.1  Golli-Mbp isoform X4

      Conserved Domains (1) summary
      pfam01669
      Location:147317
      Myelin_MBP; Myelin basic protein
    6. XM_006526454.4XP_006526517.1  Golli-Mbp isoform X3

      Conserved Domains (1) summary
      pfam01669
      Location:147324
      Myelin_MBP; Myelin basic protein
    7. XM_030250358.2XP_030106218.1  Golli-Mbp isoform X9

      Conserved Domains (1) summary
      pfam01669
      Location:147282
      Myelin_MBP; Myelin basic protein
    8. XM_006526458.4XP_006526521.1  Golli-Mbp isoform X10

      Conserved Domains (1) summary
      pfam01669
      Location:147248
      Myelin_MBP; Myelin basic protein
    9. XM_006526456.4XP_006526519.1  Golli-Mbp isoform X6

      Conserved Domains (1) summary
      pfam01669
      Location:147301
      Myelin_MBP; Myelin basic protein
    10. XM_036161013.1XP_036016906.1  Golli-Mbp isoform X7

      Conserved Domains (1) summary
      pfam01669
      Location:147291
      Myelin_MBP; Myelin basic protein
    11. XM_036161014.1XP_036016907.1  myelin basic protein isoform X11

      Conserved Domains (1) summary
      pfam01669
      Location:14217
      Myelin_MBP; Myelin basic protein
    12. XM_036161010.1XP_036016903.1  Golli-Mbp isoform X3

      Conserved Domains (1) summary
      pfam01669
      Location:147324
      Myelin_MBP; Myelin basic protein
    13. XM_030250356.1XP_030106216.1  Golli-Mbp isoform X1

      Conserved Domains (1) summary
      pfam01669
      Location:147349
      Myelin_MBP; Myelin basic protein
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