Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 268345, updated on 23-Jun-2021

    Summary

    Official Symbol
    Kcnc2provided by MGI
    Official Full Name
    potassium voltage gated channel, Shaw-related subfamily, member 2provided by MGI
    Primary source
    MGI:MGI:96668
    See related
    Ensembl:ENSMUSG00000035681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KS; Kv3.; Kv3.2; KShIIIA; AW047325; B230117I07
    Expression
    Biased expression in cortex adult (RPKM 4.9), frontal lobe adult (RPKM 4.5) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kcnc2 in Genome Data Viewer
    Location:
    10 D2; 10 60.3 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (112105803..112302209)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (112269898..112466304)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (111708179..111903360)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene GLI pathogenesis-related 1 like 3 Neighboring gene calcyphosphine 2 Neighboring gene predicted gene, 40764 Neighboring gene RIKEN cDNA 1700010J16 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated ion channel activity involved in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to nitric oxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nitric oxide-cGMP-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axolemma ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal cell body membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily C member 2
    Names
    shaw-like potassium channel
    voltage-gated potassium channel Kv3.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025581.1NP_001020752.1  potassium voltage-gated channel subfamily C member 2 isoform 2

      See identical proteins and their annotated locations for NP_001020752.1

      Status: VALIDATED

      Source sequence(s)
      AC121610, AK045425, BB641820
      Consensus CDS
      CCDS24173.1
      UniProtKB/TrEMBL
      A0A1W2P796
      Related
      ENSMUSP00000151579.2, ENSMUST00000219301.2
      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    2. NM_001359752.1NP_001346681.1  potassium voltage-gated channel subfamily C member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121610, AI835316, BC116289
      Consensus CDS
      CCDS88085.1
      Related
      ENSMUSP00000089814.4, ENSMUST00000092175.4
      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    3. NM_001359753.1NP_001346682.1  potassium voltage-gated channel subfamily C member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121610, AC153500, AI835316, BC116289
      Consensus CDS
      CCDS88085.1
      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    4. NM_001379643.1NP_001366572.1  potassium voltage-gated channel subfamily C member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121610, AC153500
      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    5. NM_001379644.1NP_001366573.1  potassium voltage-gated channel subfamily C member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121610, AC153500
      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      112105803..112302209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513693.5XP_006513756.1  potassium voltage-gated channel subfamily C member 2 isoform X4

      See identical proteins and their annotated locations for XP_006513756.1

      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    2. XM_006513692.4XP_006513755.1  potassium voltage-gated channel subfamily C member 2 isoform X4

      See identical proteins and their annotated locations for XP_006513755.1

      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    3. XM_006513695.5XP_006513758.1  potassium voltage-gated channel subfamily C member 2 isoform X5

      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    4. XM_011243455.3XP_011241757.1  potassium voltage-gated channel subfamily C member 2 isoform X2

      See identical proteins and their annotated locations for XP_011241757.1

      UniProtKB/TrEMBL
      A0A1W2P796
      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    5. XM_006513691.4XP_006513754.1  potassium voltage-gated channel subfamily C member 2 isoform X3

      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    6. XM_006513694.5XP_006513757.1  potassium voltage-gated channel subfamily C member 2 isoform X4

      See identical proteins and their annotated locations for XP_006513757.1

      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    7. XM_006513687.5XP_006513750.1  potassium voltage-gated channel subfamily C member 2 isoform X1

      See identical proteins and their annotated locations for XP_006513750.1

      UniProtKB/Swiss-Prot
      Q14B80
      UniProtKB/TrEMBL
      E9QLW0
      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    8. XM_006513690.3XP_006513753.1  potassium voltage-gated channel subfamily C member 2 isoform X1

      See identical proteins and their annotated locations for XP_006513753.1

      UniProtKB/Swiss-Prot
      Q14B80
      UniProtKB/TrEMBL
      E9QLW0
      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    9. XM_036155791.1XP_036011684.1  potassium voltage-gated channel subfamily C member 2 isoform X3

      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    10. XM_030245096.1XP_030100956.1  potassium voltage-gated channel subfamily C member 2 isoform X1

      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    11. XM_017313951.3XP_017169440.1  potassium voltage-gated channel subfamily C member 2 isoform X4

      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    12. XM_036155792.1XP_036011685.1  potassium voltage-gated channel subfamily C member 2 isoform X4

      Conserved Domains (2) summary
      cd18415
      Location:7170
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:232488
      Ion_trans; Ion transport protein
    13. XM_011243456.4XP_011241758.1  potassium voltage-gated channel subfamily C member 2 isoform X6

      Conserved Domains (1) summary
      pfam00520
      Location:31288
      Ion_trans; Ion transport protein
    Support Center