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    Podxl2 podocalyxin-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 319655, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Podxl2provided by MGI
    Official Full Name
    podocalyxin-like 2provided by MGI
    Primary source
    MGI:MGI:2442488
    See related
    Ensembl:ENSMUSG00000033152 AllianceGenome:MGI:2442488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PODLX2; D130074J02Rik
    Summary
    Predicted to be involved in leukocyte tethering or rolling. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; respiratory tract; and sensory organ. Orthologous to human PODXL2 (podocalyxin like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in whole brain E14.5 (RPKM 137.0), CNS E18 (RPKM 133.5) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 D1; 6 39.6 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88819539..88852063, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88842557..88875046, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26588 Neighboring gene monoglyceride lipase Neighboring gene STARR-positive B cell enhancer ABC_E10390 Neighboring gene ankyrin repeat and BTB domain containing 1 Neighboring gene predicted gene 15612 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88836578-88836779 Neighboring gene STARR-positive B cell enhancer ABC_E2794 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88852049-88852232 Neighboring gene minichromosome maintenance complex component 2 Neighboring gene transmembrane protein, adipocyte asscociated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons. Hsia HE, et al. FASEB J, 2021 Sep. PMID 34390512
    2. Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells. Doyonnas R, et al. Blood, 2005 Jun 1. PMID 15701716
    3. Role of CD34 family members in lumen formation in the developing kidney. Yang Z, et al. Dev Biol, 2016 Oct 1. PMID 27542690, Free PMC Article
    4. Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. van der Zwaag B, et al. Genomics, 2005 Jul. PMID 15953540
    5. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukocyte tethering or rolling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    podocalyxin-like protein 2
    Names
    endoglycan

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347327.2 → NP_001334256.1  podocalyxin-like protein 2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC153923
      Consensus CDS
      CCDS85093.1
      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      UniProtKB/TrEMBL
      D3YW47
      Related
      ENSMUSP00000117954.3, ENSMUST00000145944.3

    2. NM_001364575.2 → NP_001351504.1  podocalyxin-like protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC153923
      Consensus CDS
      CCDS20340.1
      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      UniProtKB/TrEMBL
      G3X9D3
      Related
      ENSMUSP00000058985.5, ENSMUST00000061262.11
      Conserved Domains (2) summary
      PRK14959
      Location:201 → 283
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:328 → 538
      CD34_antigen; CD34/Podocalyxin family

    3. NM_001379217.1 → NP_001366146.1  podocalyxin-like protein 2 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (3).
      Source sequence(s)
      AC153923
      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      Conserved Domains (2) summary
      PRK14959
      Location:265 → 347
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:392 → 609
      CD34_antigen; CD34/Podocalyxin family

    4. NM_001379218.1 → NP_001366147.1  podocalyxin-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153923
      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      Conserved Domains (2) summary
      PRK14959
      Location:201 → 283
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:328 → 545
      CD34_antigen; CD34/Podocalyxin family

    5. NM_001379219.1 → NP_001366148.1  podocalyxin-like protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 2, and 7-10, encodes isoform 2.
      Source sequence(s)
      AC153923
      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      UniProtKB/TrEMBL
      G3X9D3
      Conserved Domains (2) summary
      PRK14959
      Location:201 → 283
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:328 → 538
      CD34_antigen; CD34/Podocalyxin family

    6. NM_001379220.1 → NP_001366149.1  podocalyxin-like protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 2, 6, and 8-10, encodes isoform 2.
      Source sequence(s)
      AC153923
      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      UniProtKB/TrEMBL
      G3X9D3
      Conserved Domains (2) summary
      PRK14959
      Location:201 → 283
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:328 → 538
      CD34_antigen; CD34/Podocalyxin family

    7. NM_001379221.1 → NP_001366150.1  podocalyxin-like protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 2, 6, 7, 9, and isoform 210, encodes isoform 2.
      Source sequence(s)
      AC153923
      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      UniProtKB/TrEMBL
      G3X9D3
      Conserved Domains (2) summary
      PRK14959
      Location:201 → 283
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:328 → 538
      CD34_antigen; CD34/Podocalyxin family

    8. NM_001379222.1 → NP_001366151.1  podocalyxin-like protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 2, 6-8, and 10, encodes isoform 2.
      Source sequence(s)
      AC153923
      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      UniProtKB/TrEMBL
      G3X9D3
      Conserved Domains (2) summary
      PRK14959
      Location:201 → 283
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:328 → 538
      CD34_antigen; CD34/Podocalyxin family

    9. NM_001379223.1 → NP_001366152.1  podocalyxin-like protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 2, and 6-9, encodes isoform 2.
      Source sequence(s)
      AC153923
      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      UniProtKB/TrEMBL
      G3X9D3
      Conserved Domains (2) summary
      PRK14959
      Location:201 → 283
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:328 → 538
      CD34_antigen; CD34/Podocalyxin family

    10. NM_176973.5 → NP_795947.3  podocalyxin-like protein 2 isoform 2

      See identical proteins and their annotated locations for NP_795947.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3, and 6-10 all encode the same isoform (2).
      Source sequence(s)
      AC153923
      Consensus CDS
      CCDS20340.1
      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      UniProtKB/TrEMBL
      G3X9D3
      Related
      ENSMUSP00000040417.6, ENSMUST00000038409.12
      Conserved Domains (2) summary
      PRK14959
      Location:201 → 283
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:328 → 538
      CD34_antigen; CD34/Podocalyxin family

    RNA

    1. NR_166540.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153923

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      88819539..88852063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166218.1 → XP_036022111.1  podocalyxin-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      Conserved Domains (2) summary
      PRK14959
      Location:348 → 430
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:475 → 692
      CD34_antigen; CD34/Podocalyxin family

    2. XM_011241375.3 → XP_011239677.1  podocalyxin-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011239677.1

      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      Conserved Domains (2) summary
      PRK14959
      Location:201 → 283
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:328 → 545
      CD34_antigen; CD34/Podocalyxin family

    3. XM_030255448.2 → XP_030111308.1  podocalyxin-like protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      Conserved Domains (2) summary
      PRK14959
      Location:201 → 283
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:328 → 545
      CD34_antigen; CD34/Podocalyxin family

    4. XM_030255447.2 → XP_030111307.1  podocalyxin-like protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      Conserved Domains (2) summary
      PRK14959
      Location:201 → 283
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:328 → 545
      CD34_antigen; CD34/Podocalyxin family

    5. XM_030255445.1 → XP_030111305.1  podocalyxin-like protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      Conserved Domains (2) summary
      PRK14959
      Location:274 → 356
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:401 → 618
      CD34_antigen; CD34/Podocalyxin family

    6. XM_011241376.2 → XP_011239678.1  podocalyxin-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011239678.1

      UniProtKB/Swiss-Prot
      Q8CAE9, Q8CFW3
      Conserved Domains (2) summary
      PRK14959
      Location:201 → 283
      PRK14959; DNA polymerase III subunits gamma and tau; Provisional
      pfam06365
      Location:328 → 545
      CD34_antigen; CD34/Podocalyxin family

    RNA

    1. XR_004942963.1 RNA Sequence

    2. XR_004942964.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CAE9.2 GenPept UniProtKB/Swiss-Prot:Q8CAE9

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