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    Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) [ Mus musculus (house mouse) ]

    Gene ID: 12983, updated on 11-Apr-2024

    Summary

    Official Symbol
    Csf2rbprovided by MGI
    Official Full Name
    colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)provided by MGI
    Primary source
    MGI:MGI:1339759
    See related
    Ensembl:ENSMUSG00000071713 AllianceGenome:MGI:1339759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bc; Il3r; AIC2B; Il3rb; Il5rb; CDw131; Il3rb1; Csf2rb1; Csfgmrb
    Summary
    Predicted to enable cytokine receptor activity. Acts upstream of or within cytokine-mediated signaling pathway and regulation of cell growth. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including bone marrow; cardiovascular system mesenchyme; dorsal aorta; genitourinary system; and yolk sac. Used to study pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human CSF2RB (colony stimulating factor 2 receptor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in mammary gland adult (RPKM 30.9), spleen adult (RPKM 19.6) and 16 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    15 E1; 15 37.36 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78210000..78235201)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78325800..78351001)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9914 Neighboring gene neutrophil cytosolic factor 4 Neighboring gene microRNA 7676-1 Neighboring gene colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) Neighboring gene microRNA 7676-2 Neighboring gene ciliary microtubule inner protein 4 Neighboring gene STARR-seq mESC enhancer starr_39143 Neighboring gene thiosulfate sulfurtransferase, mitochondrial

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (8)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC130522

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of granulocyte macrophage colony-stimulating factor receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytokine receptor common subunit beta
    Names
    CD131 antigen
    GM-CSF/IL-3/IL-5 receptor common beta subunit
    GM-CSF/IL-3/IL-5 receptor common beta-chain
    beta c
    colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage)
    common beta chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358854.1NP_001345783.1  cytokine receptor common subunit beta precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL583893
      Consensus CDS
      CCDS27612.1
      UniProtKB/Swiss-Prot
      P26955, Q3U7L5
      UniProtKB/TrEMBL
      Q3U2T6, Q8QZX9
      Related
      ENSMUSP00000154836.2, ENSMUST00000230264.3
      Conserved Domains (3) summary
      cd00063
      Location:346439
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:250316
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl26464
      Location:551809
      Atrophin-1; Atrophin-1 family
    2. NM_007780.4NP_031806.3  cytokine receptor common subunit beta precursor

      See identical proteins and their annotated locations for NP_031806.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI467222, AK152608, AL583893
      Consensus CDS
      CCDS27612.1
      UniProtKB/Swiss-Prot
      P26955, Q3U7L5
      UniProtKB/TrEMBL
      Q3U2T6, Q8QZX9
      Related
      ENSMUSP00000094082.4, ENSMUST00000096355.4
      Conserved Domains (3) summary
      cd00063
      Location:346439
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:250316
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl26464
      Location:551809
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78210000..78235201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)