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    Fbxl7 F-box and leucine-rich repeat protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 448987, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Fbxl7provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 7provided by MGI
    Primary source
    MGI:MGI:3052506
    See related
    Ensembl:ENSMUSG00000043556 AllianceGenome:MGI:3052506
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBL7; Fbl6; D230018M15Rik
    Summary
    Involved in G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Located in centrosome. Part of SCF ubiquitin ligase complex. Orthologous to human FBXL7 (F-box and leucine rich repeat protein 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 5.8), ovary adult (RPKM 5.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 B1; 15 9.87 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (26540540..26895650, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (26540454..26895564, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 11 Neighboring gene STARR-seq mESC enhancer starr_38209 Neighboring gene STARR-seq mESC enhancer starr_38210 Neighboring gene predicted gene, 36790 Neighboring gene predicted gene, 52206 Neighboring gene STARR-seq mESC enhancer starr_38211 Neighboring gene predicted gene, 52205 Neighboring gene gem-associated protein 4-like Neighboring gene ecdysoneless homolog pseudogene Neighboring gene predicted gene, 18093 Neighboring gene STARR-seq mESC enhancer starr_38213 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 23903

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest. Coon TA, et al. Cell Cycle, 2012 Feb 15. PMID 22306998, Free PMC Article
    2. The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin. Liu Y, et al. J Biol Chem, 2015 May 8. PMID 25778398, Free PMC Article
    3. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    4. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267
    5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the Skp1.Cul1.F-box protein complex subunit Fbxl7 modulates mitochondrial function by controlling the cellular abundance of survivin
      Title: The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.
    2. FBXL7 specifically interacts with Aurora A during mitosis but not in interphase, suggesting a regulatory role for FBXL7 in controlling Aurora A abundance during mitosis.
      Title: Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102204

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176959.3 → NP_795933.2  F-box/LRR-repeat protein 7

      See identical proteins and their annotated locations for NP_795933.2

      Status: PROVISIONAL

      Source sequence(s)
      BC091646
      Consensus CDS
      CCDS37052.1
      UniProtKB/Swiss-Prot
      Q5BJ29, Q6ZQ36
      Related
      ENSMUSP00000061305.10, ENSMUST00000059204.11
      Conserved Domains (3) summary
      cd09293
      Location:297 → 464
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:240 → 273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:114 → 160
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      26540540..26895650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520106.5 → XP_006520169.1  F-box/LRR-repeat protein 7 isoform X1

      See identical proteins and their annotated locations for XP_006520169.1

      Conserved Domains (3) summary
      cd09293
      Location:250 → 417
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:193 → 226
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:67 → 110
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJ29.1 GenPept UniProtKB/Swiss-Prot:Q5BJ29

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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