Clec1a C-type lectin domain family 1, member a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec1aprovided by MGI
Official Full Name: C-type lectin domain family 1, member aprovided by MGI
Primary source: MGI:MGI:2444151
See related: Ensembl:ENSMUSG00000033082 AllianceGenome:MGI:2444151
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5930406N14Rik
Summary: Predicted to enable carbohydrate binding activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including adrenal gland; brain; gut; heart ventricle; and lung. Human ortholog(s) of this gene implicated in aspergillosis. Orthologous to human CLEC1A (C-type lectin domain family 1 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 14.8), ovary adult (RPKM 2.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 63.32 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129403647..129428963, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129426684..129452000, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17.
Title: The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-type lectin domain family 1 member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347475.1 → NP_001334404.1 C-type lectin domain family 1 member A isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate frame-shifting splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2) with a distinct C-terminus, compared to isoform 1

Source sequence(s)

AC138620, AK031121, AK036846, BC052840, BX512526

Consensus CDS

CCDS85169.1

UniProtKB/TrEMBL

A0A0N4SV03, Q8BZ31

Related

ENSMUSP00000144896.2, ENSMUST00000203162.3
NM_175526.3 → NP_780735.2 C-type lectin domain family 1 member A isoform 1

See identical proteins and their annotated locations for NP_780735.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC138620, AK049608, BX512526

Consensus CDS

CCDS20587.1

UniProtKB/Swiss-Prot

Q7TPX7, Q8BMH5, Q8BWY2

Related

ENSMUSP00000047065.8, ENSMUST00000037481.10

Conserved Domains (1) summary

cd03593
Location:136 → 258

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)