Pcgf2 polycomb group ring finger 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcgf2provided by MGI
Official Full Name: polycomb group ring finger 2provided by MGI
Primary source: MGI:MGI:99161
See related: Ensembl:ENSMUSG00000018537 AllianceGenome:MGI:99161
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mel18; Rnf110; Zfp144; mel-18
Summary: Enables chromatin binding activity. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; chordate embryonic development; and negative regulation of apoptotic signaling pathway. Located in nuclear body and sex chromatin. Part of PcG protein complex. Is expressed in several structures, including adipose tissue; alimentary system; brain; eye; and genitourinary system. Orthologous to human PCGF2 (polycomb group ring finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E14 (RPKM 21.4), whole brain E14.5 (RPKM 19.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 61.06 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (97579647..97593260, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (97688821..97702434, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BMI1 and MEL18 contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells.
Title: BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3.
Data indicate that Bmi1 and Mel18 have opposing functions and are present in distinct complexes.
Title: Regulation of hematopoietic stem cells using protein transduction domain-fused Polycomb.
Mel-18 controls the enrichment of tumor-initiating cells in side population fraction in mouse mammary gland cancer.
Title: Mel-18 controls the enrichment of tumor-initiating cells in SP fraction in mouse breast cancer.
Data show that Mel-18 and Ezh2 positively regulate the expression of Il17a and Il17f.
Title: The binding activity of Mel-18 at the Il17a promoter is regulated by the integrated signals of the TCR and polarizing cytokines.
observed that expression of the PcG genes-bmi1 and mel-18-is correlated with self-renewal and differentiation of HSCs. Thus, it was suggested that the balance between Bmi1 and Mel-18 regulates self-renewal of HSCs
Title: Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells.
Sf3b1-Zfp144 protein interaction is essential for true Polycomb group proteins mediated repression of Hox genes.
Title: Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1.
involved in the specification of the anterior-posterior axis in mice
Title: Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.
Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18
Title: Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18.
Loss or knockdown of mel-18 leads to the expression of Hoxb4, an increase in the proportion of hematopoietic stem cells in G0 phase, and the subsequent promotion of HSC self-renewal.
Title: Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells.
Mel-18 contributes to the maintenance of the active state of the Hes-1 gene as a cellular memory system, thereby supporting the expansion of early T lymphocyte progenitors.
Title: Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the Notch pathway.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables ubiquitin-protein transferase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chromatin organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PRC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PRC1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of PRC1 complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of sex chromatin	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polycomb group RING finger protein 2

Names: DNA-binding protein Mel-18; melanoma nuclear protein 18; ring finger protein 110; zfp-144; zinc finger protein 144

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163307.1 → NP_001156779.1 polycomb group RING finger protein 2

See identical proteins and their annotated locations for NP_001156779.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.

Source sequence(s)

AK142837, BB406926, BI991588, D90085

Consensus CDS

CCDS25327.1

UniProtKB/Swiss-Prot

P23798

Related

ENSMUSP00000137517.2, ENSMUST00000179765.8

Conserved Domains (3) summary

PHA03247
Location:222 → 304

PHA03247; large tegument protein UL36; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17164
Location:130 → 228

RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
NM_001163308.1 → NP_001156780.1 polycomb group RING finger protein 2

See identical proteins and their annotated locations for NP_001156780.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.

Source sequence(s)

AK142837, BB406926, D90085

Consensus CDS

CCDS25327.1

UniProtKB/Swiss-Prot

P23798

Related

ENSMUSP00000126967.2, ENSMUST00000169807.8

Conserved Domains (3) summary

PHA03247
Location:222 → 304

PHA03247; large tegument protein UL36; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17164
Location:130 → 228

RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
NM_009545.2 → NP_033571.1 polycomb group RING finger protein 2

See identical proteins and their annotated locations for NP_033571.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.

Source sequence(s)

AK142837, BB406926, BB872501, BY008477, D90085

Consensus CDS

CCDS25327.1

UniProtKB/Swiss-Prot

P23798

Related

ENSMUSP00000018681.8, ENSMUST00000018681.14

Conserved Domains (3) summary

PHA03247
Location:222 → 304

PHA03247; large tegument protein UL36; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17164
Location:130 → 228

RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

97579647..97593260 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156633.1 → XP_036012526.1 polycomb group RING finger protein 2 isoform X1

UniProtKB/Swiss-Prot

P23798

Conserved Domains (3) summary

PHA03247
Location:222 → 304

PHA03247; large tegument protein UL36; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17164
Location:130 → 228

RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
XM_011248975.3 → XP_011247277.1 polycomb group RING finger protein 2 isoform X1

See identical proteins and their annotated locations for XP_011247277.1

UniProtKB/Swiss-Prot

P23798

Conserved Domains (3) summary

PHA03247
Location:222 → 304

PHA03247; large tegument protein UL36; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17164
Location:130 → 228

RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
XM_011248972.3 → XP_011247274.1 polycomb group RING finger protein 2 isoform X1

See identical proteins and their annotated locations for XP_011247274.1

UniProtKB/Swiss-Prot

P23798

Conserved Domains (3) summary

PHA03247
Location:222 → 304

PHA03247; large tegument protein UL36; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17164
Location:130 → 228

RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
XM_036156632.1 → XP_036012525.1 polycomb group RING finger protein 2 isoform X1

UniProtKB/Swiss-Prot

P23798

Conserved Domains (3) summary

PHA03247
Location:222 → 304

PHA03247; large tegument protein UL36; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17164
Location:130 → 228

RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
XM_011248973.3 → XP_011247275.1 polycomb group RING finger protein 2 isoform X1

See identical proteins and their annotated locations for XP_011247275.1

UniProtKB/Swiss-Prot

P23798

Conserved Domains (3) summary

PHA03247
Location:222 → 304

PHA03247; large tegument protein UL36; Provisional

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17164
Location:130 → 228

RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)