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    Zfp949 zinc finger protein 949 [ Mus musculus (house mouse) ]

    Gene ID: 71640, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp949provided by MGI
    Official Full Name
    zinc finger protein 949provided by MGI
    Primary source
    MGI:MGI:1918890
    See related
    Ensembl:ENSMUSG00000032425 AllianceGenome:MGI:1918890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nczf; 4930422I07Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 4.6), frontal lobe adult (RPKM 3.8) and 28 other tissues See more
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    Genomic context

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    Location:
    9 E3.1; 9 47.24 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (88430073..88453139)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (88548020..88571086)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E251 Neighboring gene small nucleolar RNA, C/D box 50B Neighboring gene small nucleolar RNA host gene 5 Neighboring gene predicted gene, 22985 Neighboring gene STARR-positive B cell enhancer ABC_E6783 Neighboring gene STARR-positive B cell enhancer ABC_E8859 Neighboring gene tripartite motif-containing 43A Neighboring gene predicted gene, 51715 Neighboring gene RIKEN cDNA 9430037G07 gene Neighboring gene transcription elongation factor B polypeptide 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of the consensus DNA sequence for Nczf binding. Kitahashi M, et al. DNA Cell Biol, 2007 Jun. PMID 17570763
    2. Transcriptional repression of p27 is essential for murine embryonic development. Teratake Y, et al. Sci Rep, 2016 May 19. PMID 27196371, Free PMC Article
    3. Candidate genes and their regulatory elements: alcohol preference and tolerance. Saba L, et al. Mamm Genome, 2006 Jun. PMID 16783646
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC71640

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142943.1 → NP_001136415.1  uncharacterized protein LOC71640

      See identical proteins and their annotated locations for NP_001136415.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC163666, AK015179, BC141010, BU610496
      Consensus CDS
      CCDS52880.1
      UniProtKB/TrEMBL
      E9Q732
      Related
      ENSMUSP00000125325.2, ENSMUST00000162827.8
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:246 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 458
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001163061.1 → NP_001156533.1  uncharacterized protein LOC71640

      See identical proteins and their annotated locations for NP_001156533.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC163666, CT025673
      Consensus CDS
      CCDS52880.1
      UniProtKB/TrEMBL
      E9Q732
      Related
      ENSMUSP00000125017.2, ENSMUST00000161458.3
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:246 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 458
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      88430073..88453139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244606.1 → XP_030100466.1  uncharacterized protein LOC71640 isoform X1

      UniProtKB/TrEMBL
      E9Q732
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:246 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 458
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036155290.1 → XP_036011183.1  uncharacterized protein LOC71640 isoform X1

      UniProtKB/TrEMBL
      E9Q732
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:246 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 458
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030244605.1 → XP_030100465.1  uncharacterized protein LOC71640 isoform X1

      UniProtKB/TrEMBL
      E9Q732
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:246 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 458
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_017313596.2 → XP_017169085.1  uncharacterized protein LOC71640 isoform X1

      UniProtKB/TrEMBL
      E9Q732
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:246 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 458
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_036155291.1 → XP_036011184.1  uncharacterized protein LOC71640 isoform X1

      UniProtKB/TrEMBL
      E9Q732
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:246 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 458
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_006511446.5 → XP_006511509.1  uncharacterized protein LOC71640 isoform X1

      See identical proteins and their annotated locations for XP_006511509.1

      UniProtKB/TrEMBL
      E9Q732
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:246 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 458
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_030244604.2 → XP_030100464.1  uncharacterized protein LOC71640 isoform X1

      UniProtKB/TrEMBL
      E9Q732
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:246 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 458
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_030244607.2 → XP_030100467.1  uncharacterized protein LOC71640 isoform X1

      UniProtKB/TrEMBL
      E9Q732
      Conserved Domains (3) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:246 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:438 → 458
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_030244608.2 → XP_030100468.1  uncharacterized protein LOC71640 isoform X2

      Conserved Domains (3) summary
      smart00349
      Location:2 → 38
      KRAB; krueppel associated box
      COG5048
      Location:216 → 564
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:408 → 428
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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