Hnrnpf heterogeneous nuclear ribonucleoprotein F [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hnrnpfprovided by MGI
Official Full Name: heterogeneous nuclear ribonucleoprotein Fprovided by MGI
Primary source: MGI:MGI:2138741
See related: Ensembl:ENSMUSG00000042079 AllianceGenome:MGI:2138741
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hnrpf; 4833420I20Rik
Summary: Predicted to enable TBP-class protein binding activity and single-stranded RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytosol and nucleus. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleoplasm. Is expressed in branchial arch; central nervous system; and sensory organ. Used to study renal glycosuria. Orthologous to human HNRNPF (heterogeneous nuclear ribonucleoprotein F). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 143.4), liver E14.5 (RPKM 122.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 55.66 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (117877301..117902583)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (117900340..117925622)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition.
Title: Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition.
Tubular Deficiency of Heterogeneous Nuclear Ribonucleoprotein F Elevates Systolic Blood Pressure and Induces Glycosuria in Mice.
Title: Tubular Deficiency of Heterogeneous Nuclear Ribonucleoprotein F Elevates Systolic Blood Pressure and Induces Glycosuria in Mice.
FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing
Title: FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing.
hnRNP F protects kidneys against oxidative stress and nephropathy via stimulation of Sirtuin-1 expression and signaling in diabetes.
Title: Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene Expression and Attenuates Nephropathy Progression in Diabetic Mice.
the beneficial actions of insulin in diabetic nephropathy appear to be mediated, in part, by suppressing renal Nrf2 and Agt gene transcription and preventing Nrf2 stimulation of Agt expression via hnRNP F/K.
Title: Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice.
These data demonstrate that hnRNP F stimulates Ace-2 gene transcription, prevents TGF-beta1 inhibition of Ace-2 gene transcription and induction of kidney injury in diabetes.
Title: Overexpression of heterogeneous nuclear ribonucleoprotein F stimulates renal Ace-2 gene expression and prevents TGF-β1-induced kidney injury in a mouse model of diabetes.
genome wide analysis of splicing events and gene expression regulated by hnRNPH/F in oligodendrocytes
Title: Global profiling of alternative splicing events and gene expression regulated by hnRNPH/F.
These data suggest that hnRNP F plays a modulatory role and can ameliorate hypertension, renal hypertrophy, and interstitial fibrosis in diabetes.
Title: Heterogeneous nuclear ribonucleoprotein F suppresses angiotensinogen gene expression and attenuates hypertension and kidney injury in diabetic mice.
The hnRNP F can function as repressors of MOR translation dependent on the M4 sequence.
Title: Post-transcriptional regulation of mu-opioid receptor: role of the RNA-binding proteins heterogeneous nuclear ribonucleoprotein H1 and F.
define hnRNP F as a regulatory element of MBP expression in oligodendrocytes and imply an important function of hnRNP F in the control of myelin synthesis.
Title: Heterogeneous nuclear ribonucleoprotein (hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myelin basic protein (MBP) synthesis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hnrnpf (e-PCR), detects polymorphism
- UniSTS:526081

19.MMHAP41FLG1.seq (e-PCR)
- UniSTS:123431

Hnrpf (e-PCR), detects polymorphism
- UniSTS:479123

RH125671 (e-PCR)
- UniSTS:162452

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein F

Names: hnRNP F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166427.1 → NP_001159899.1 heterogeneous nuclear ribonucleoprotein F

See identical proteins and their annotated locations for NP_001159899.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.

Source sequence(s)

BC047346, CJ094336, CX218091

Consensus CDS

CCDS20467.1

UniProtKB/Swiss-Prot

Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1

Related

ENSMUSP00000137632.2, ENSMUST00000180020.8

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12506
Location:289 → 363

RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
NM_001166428.1 → NP_001159900.1 heterogeneous nuclear ribonucleoprotein F

See identical proteins and their annotated locations for NP_001159900.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.

Source sequence(s)

BC047346, BY774552, CA539382, CJ054614, CX218091

Consensus CDS

CCDS20467.1

UniProtKB/Swiss-Prot

Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12506
Location:289 → 363

RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
NM_001166429.1 → NP_001159901.1 heterogeneous nuclear ribonucleoprotein F

See identical proteins and their annotated locations for NP_001159901.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.

Source sequence(s)

BC047346, BY774552, CK389060, CX218091

Consensus CDS

CCDS20467.1

UniProtKB/Swiss-Prot

Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12506
Location:289 → 363

RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
NM_001166430.1 → NP_001159902.1 heterogeneous nuclear ribonucleoprotein F

See identical proteins and their annotated locations for NP_001159902.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.

Source sequence(s)

AU079872, BC047346, CJ048596, CJ169112, CX218091

Consensus CDS

CCDS20467.1

UniProtKB/Swiss-Prot

Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12506
Location:289 → 363

RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
NM_001166431.1 → NP_001159903.1 heterogeneous nuclear ribonucleoprotein F

See identical proteins and their annotated locations for NP_001159903.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.

Source sequence(s)

BC047346, CJ048596, CJ094704, CX218091

Consensus CDS

CCDS20467.1

UniProtKB/Swiss-Prot

Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1

Related

ENSMUSP00000130023.3, ENSMUST00000163168.9

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12506
Location:289 → 363

RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
NM_001166432.1 → NP_001159904.1 heterogeneous nuclear ribonucleoprotein F

See identical proteins and their annotated locations for NP_001159904.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.

Source sequence(s)

BC047346, CF163622, CX218091

Consensus CDS

CCDS20467.1

UniProtKB/Swiss-Prot

Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1

Related

ENSMUSP00000126817.2, ENSMUST00000167182.8

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12506
Location:289 → 363

RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
NM_133834.2 → NP_598595.1 heterogeneous nuclear ribonucleoprotein F

See identical proteins and their annotated locations for NP_598595.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-7 encode the same protein.

Source sequence(s)

AK076478, BC047346, CJ048596, CX218091

Consensus CDS

CCDS20467.1

UniProtKB/Swiss-Prot

Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1

Related

ENSMUSP00000045048.8, ENSMUST00000035493.14

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12506
Location:289 → 363

RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

117877301..117902583

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506829.5 → XP_006506892.1 heterogeneous nuclear ribonucleoprotein F isoform X1

See identical proteins and their annotated locations for XP_006506892.1

UniProtKB/Swiss-Prot

Q5FWK2, Q8BVU8, Q8K2U9, Q8R0E7, Q9Z2X1

Conserved Domains (4) summary

pfam08080
Location:255 → 290

zf-RNPHF; RNPHF zinc finger

cd12506
Location:289 → 363

RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12729
Location:10 → 88

RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

cd12731
Location:103 → 192

RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins