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    Kcna6 potassium voltage-gated channel, shaker-related, subfamily, member 6 [ Mus musculus (house mouse) ]

    Gene ID: 16494, updated on 23-Jun-2021

    Summary

    Official Symbol
    Kcna6provided by MGI
    Official Full Name
    potassium voltage-gated channel, shaker-related, subfamily, member 6provided by MGI
    Primary source
    MGI:MGI:96663
    See related
    Ensembl:ENSMUSG00000038077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kv1.; Kv1.6; MK1.6
    Expression
    Biased expression in cerebellum adult (RPKM 9.9), cortex adult (RPKM 8.5) and 7 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kcna6 in Genome Data Viewer
    Location:
    6 F3; 6 61.72 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126685291..126717797, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126708328..126740834, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (126658347..126690692, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33496 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 1 Neighboring gene predicted gene, 33581 Neighboring gene predicted gene, 20190 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily A member 6
    Names
    voltage-gated potassium channel subunit Kv1.6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013568.6NP_038596.1  potassium voltage-gated channel subfamily A member 6

      See identical proteins and their annotated locations for NP_038596.1

      Status: VALIDATED

      Source sequence(s)
      AC124756, BC048782, BC054804, BE948246
      Consensus CDS
      CCDS20556.1
      UniProtKB/Swiss-Prot
      Q61923
      Related
      ENSMUSP00000139481.2, ENSMUST00000185333.2
      Conserved Domains (2) summary
      cd18407
      Location:41170
      BTB_POZ_KCNA6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6)
      pfam00520
      Location:258468
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      126685291..126717797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241228.3XP_011239530.1  potassium voltage-gated channel subfamily A member 6 isoform X1

      See identical proteins and their annotated locations for XP_011239530.1

      UniProtKB/Swiss-Prot
      Q61923
      Related
      ENSMUSP00000107861.2, ENSMUST00000112242.2
      Conserved Domains (2) summary
      cd18407
      Location:41170
      BTB_POZ_KCNA6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6)
      pfam00520
      Location:258468
      Ion_trans; Ion transport protein
    2. XM_006505639.4XP_006505702.1  potassium voltage-gated channel subfamily A member 6 isoform X1

      See identical proteins and their annotated locations for XP_006505702.1

      UniProtKB/Swiss-Prot
      Q61923
      Conserved Domains (2) summary
      cd18407
      Location:41170
      BTB_POZ_KCNA6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6)
      pfam00520
      Location:258468
      Ion_trans; Ion transport protein
    3. XM_006505638.4XP_006505701.1  potassium voltage-gated channel subfamily A member 6 isoform X1

      See identical proteins and their annotated locations for XP_006505701.1

      UniProtKB/Swiss-Prot
      Q61923
      Conserved Domains (2) summary
      cd18407
      Location:41170
      BTB_POZ_KCNA6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6)
      pfam00520
      Location:258468
      Ion_trans; Ion transport protein
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