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    Klre1 killer cell lectin-like receptor family E member 1 [ Mus musculus (house mouse) ]

    Gene ID: 243655, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Klre1provided by MGI
    Official Full Name
    killer cell lectin-like receptor family E member 1provided by MGI
    Primary source
    MGI:MGI:2662547
    See related
    Ensembl:ENSMUSG00000050241 AllianceGenome:MGI:2662547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NKG2I; Klre-1
    Summary
    Enables identical protein binding activity and transmembrane signaling receptor activity. Acts upstream of or within natural killer cell activation; positive regulation of innate immune response; and positive regulation of interferon-gamma production. Located in external side of plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    6 F3; 6 63.41 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129536329..129562790)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129559365..129585828)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 52B Neighboring gene RIKEN cDNA 1700101I11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:129481855-129482155 Neighboring gene GABA type A receptor associated protein like 1 Neighboring gene STARR-positive B cell enhancer ABC_E10411 Neighboring gene STARR-positive B cell enhancer mm9_chr6:129531448-129531748 Neighboring gene killer cell lectin-like receptor, subfamily D, member 1 Neighboring gene killer cell lectin-like receptor subfamily K, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of a NK receptor, KLRE-1, in bone marrow allograft rejection: analysis with KLRE-1-deficient mice. Shimizu E, et al. Blood, 2004 Aug 1. PMID 15069013
    2. Identification of a new murine lectin-like gene in close proximity to CD94. Wilhelm BT, et al. Immunogenetics, 2003 Apr. PMID 12715246
    3. The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. Westgaard IH, et al. J Exp Med, 2003 Jun 2. PMID 12782717, Free PMC Article
    4. KLRE/I1 and KLRE/I2: a novel pair of heterodimeric receptors that inversely regulate NK cell cytotoxicity. Saether PC, et al. J Immunol, 2008 Sep 1. PMID 18713988, Free PMC Article
    5. Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I. Koike J, et al. J Exp Med, 2004 Jan 5. PMID 14707119, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloning and functional characterization of a novel natural killer (NK) cell receptor termed KLRE1
      Title: The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity.
    2. mediates recognition and rejection of allogeneic target cells in the host immune system
      Title: Role of a NK receptor, KLRE-1, in bone marrow allograft rejection: analysis with KLRE-1-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within natural killer cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of natural killer cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in stimulatory C-type lectin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within stimulatory C-type lectin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of type II interferon production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    killer cell lectin-like receptor subfamily E member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001381986.1 → NP_001368915.1  killer cell lectin-like receptor subfamily E member 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161602
      UniProtKB/Swiss-Prot
      Q80WP0, Q8CJC7
      Conserved Domains (1) summary
      cd03593
      Location:113 → 226
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. NM_001381987.1 → NP_001368916.1  killer cell lectin-like receptor subfamily E member 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161602
      Conserved Domains (1) summary
      cl02432
      Location:113 → 158
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    3. NM_001381988.1 → NP_001368917.1  killer cell lectin-like receptor subfamily E member 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161602
      Conserved Domains (1) summary
      cl02432
      Location:113 → 158
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    4. NM_153590.3 → NP_705818.3  killer cell lectin-like receptor subfamily E member 1 isoform 1

      See identical proteins and their annotated locations for NP_705818.3

      Status: VALIDATED

      Source sequence(s)
      AF306663, BG145575, BX518942
      Consensus CDS
      CCDS20589.1
      UniProtKB/Swiss-Prot
      Q80WP0, Q8CJC7
      Related
      ENSMUSP00000055779.7, ENSMUST00000053708.9
      Conserved Domains (1) summary
      cd03593
      Location:113 → 226
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129536329..129562790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506123.4 → XP_006506186.1  killer cell lectin-like receptor subfamily E member 1 isoform X2

      See identical proteins and their annotated locations for XP_006506186.1

      UniProtKB/Swiss-Prot
      Q80WP0, Q8CJC7
      Conserved Domains (1) summary
      cd03593
      Location:113 → 226
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. XM_017321589.3 → XP_017177078.1  killer cell lectin-like receptor subfamily E member 1 isoform X2

      UniProtKB/Swiss-Prot
      Q80WP0, Q8CJC7
      Conserved Domains (1) summary
      cd03593
      Location:113 → 226
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    3. XM_006506121.1 → XP_006506184.1  killer cell lectin-like receptor subfamily E member 1 isoform X1

      Conserved Domains (1) summary
      cd03593
      Location:139 → 252
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    4. XM_006506128.3 → XP_006506191.1  killer cell lectin-like receptor subfamily E member 1 isoform X3

      Conserved Domains (1) summary
      cl02432
      Location:139 → 184
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    5. XM_036166121.1 → XP_036022014.1  killer cell lectin-like receptor subfamily E member 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CJC7.1 GenPept UniProtKB/Swiss-Prot:Q8CJC7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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