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    Stox2 storkhead box 2 [ Mus musculus (house mouse) ]

    Gene ID: 71069, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Stox2provided by MGI
    Official Full Name
    storkhead box 2provided by MGI
    Primary source
    MGI:MGI:1918319
    See related
    Ensembl:ENSMUSG00000038143 AllianceGenome:MGI:1918319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1392; 4933409N07Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within response to bacterium. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human STOX2 (storkhead box 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 6.7), CNS E14 (RPKM 6.3) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 B1.1; 8 26.61 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (47633083..47866943, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (47180048..47413847, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 6 Neighboring gene predicted gene, 31231 Neighboring gene STARR-seq mESC enhancer starr_21399 Neighboring gene predicted gene, 51569 Neighboring gene STARR-seq mESC enhancer starr_21401 Neighboring gene predicted gene, 51570 Neighboring gene STARR-seq mESC enhancer starr_21406 Neighboring gene STARR-seq mESC enhancer starr_21407 Neighboring gene predicted gene, 39171 Neighboring gene STARR-seq mESC enhancer starr_21409 Neighboring gene predicted gene, 22857 Neighboring gene trafficking protein particle complex 11 Neighboring gene STARR-positive B cell enhancer ABC_E1754

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
    2. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    4. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107432

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    storkhead-box protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114311.1 → NP_001107783.1  storkhead-box protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001107783.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AC105173, AC134442
      Consensus CDS
      CCDS52548.1
      UniProtKB/Swiss-Prot
      B2RR59, Q3TRF0, Q497F9, Q499E5, Q6ZPS3, Q8CDI1
      Related
      ENSMUSP00000078190.6, ENSMUST00000079195.6
      Conserved Domains (1) summary
      pfam10264
      Location:64 → 140
      Stork_head; Winged helix Storkhead-box1 domain

    2. NM_001286376.1 → NP_001273305.1  storkhead-box protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon, lacks a portion of the 3' coding region, and differs in the 3' UTR, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      AC105173, AC134442, AK129346
      Consensus CDS
      CCDS85535.1
      UniProtKB/Swiss-Prot
      Q499E5
      Related
      ENSMUSP00000147477.2, ENSMUST00000211737.2
      Conserved Domains (1) summary
      pfam10264
      Location:64 → 140
      Stork_head; Winged helix Storkhead-box1 domain

    3. NM_001363119.1 → NP_001350048.1  storkhead-box protein 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC105173, AC134442

    4. NM_175162.4 → NP_780371.3  storkhead-box protein 2 isoform 2

      See identical proteins and their annotated locations for NP_780371.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' and 3' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC102862, AC134442
      Consensus CDS
      CCDS40336.1
      UniProtKB/Swiss-Prot
      Q499E5
      Related
      ENSMUSP00000105996.3, ENSMUST00000110367.10
      Conserved Domains (1) summary
      pfam10264
      Location:1 → 79
      Stork_head; Winged helix Storkhead-box1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      47633083..47866943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243766.2 → XP_030099626.1  storkhead-box protein 2 isoform X1

      Conserved Domains (1) summary
      pfam10264
      Location:128 → 204
      Stork_head; Winged helix Storkhead-box1 domain

    2. XM_036154293.1 → XP_036010186.1  storkhead-box protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RMH0
      Related
      ENSMUSP00000148776.2, ENSMUST00000211882.2
      Conserved Domains (1) summary
      pfam10264
      Location:127 → 205
      Stork_head; Winged helix Storkhead-box1 domain

    3. XM_036154295.1 → XP_036010188.1  storkhead-box protein 2 isoform X6

    4. XM_036154296.1 → XP_036010189.1  storkhead-box protein 2 isoform X6

    5. XM_006509495.5 → XP_006509558.1  storkhead-box protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006509558.1

      Conserved Domains (1) summary
      pfam10264
      Location:2 → 78
      Stork_head; Winged helix Storkhead-box1 domain

    6. XM_006509492.5 → XP_006509555.1  storkhead-box protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006509555.1

      Conserved Domains (1) summary
      pfam10264
      Location:2 → 78
      Stork_head; Winged helix Storkhead-box1 domain

    7. XM_030243768.2 → XP_030099628.1  storkhead-box protein 2 isoform X7

    8. XM_036154294.1 → XP_036010187.1  storkhead-box protein 2 isoform X5

      Conserved Domains (1) summary
      pfam10264
      Location:1 → 79
      Stork_head; Winged helix Storkhead-box1 domain

    9. XM_030243767.2 → XP_030099627.1  storkhead-box protein 2 isoform X6

    10. XM_017312966.3 → XP_017168455.1  storkhead-box protein 2 isoform X4

      Conserved Domains (1) summary
      pfam10264
      Location:2 → 78
      Stork_head; Winged helix Storkhead-box1 domain

    11. XM_006509491.5 → XP_006509554.1  storkhead-box protein 2 isoform X3

      Conserved Domains (1) summary
      pfam10264
      Location:31 → 107
      Stork_head; Winged helix Storkhead-box1 domain

    12. XM_011242237.3 → XP_011240539.1  storkhead-box protein 2 isoform X5

      See identical proteins and their annotated locations for XP_011240539.1

      UniProtKB/Swiss-Prot
      Q499E5
      Related
      ENSMUSP00000147281.2, ENSMUST00000210030.2
      Conserved Domains (1) summary
      pfam10264
      Location:1 → 79
      Stork_head; Winged helix Storkhead-box1 domain

    13. XM_006509494.4 → XP_006509557.1  storkhead-box protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006509557.1

      Conserved Domains (1) summary
      pfam10264
      Location:2 → 78
      Stork_head; Winged helix Storkhead-box1 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499E5.2 GenPept UniProtKB/Swiss-Prot:Q499E5

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