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    Gnl3l guanine nucleotide binding protein nucleolar 3 like [ Mus musculus (house mouse) ]

    Gene ID: 237107, updated on 23-Apr-2024

    Summary

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    Official Symbol
    Gnl3lprovided by MGI
    Official Full Name
    guanine nucleotide binding protein nucleolar 3 likeprovided by MGI
    Primary source
    MGI:MGI:2448557
    See related
    Ensembl:ENSMUSG00000025266 AllianceGenome:MGI:2448557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in several processes, including negative regulation of protein modification by small protein conjugation or removal; negative regulation of telomere maintenance via telomerase; and positive regulation of protein localization to chromosome, telomeric region. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in nucleolus. Orthologous to human GNL3L (G protein nucleolar 3 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 22.1), frontal lobe adult (RPKM 21.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X F3; X 68.46 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (149766129..149800318, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (150983133..151017322, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54086 Neighboring gene inter-alpha-trypsin inhibitor heavy chain family member 6 Neighboring gene STARR-seq mESC enhancer starr_48073 Neighboring gene polypyrimidine tract binding protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8765 Neighboring gene STARR-seq mESC enhancer starr_48075 Neighboring gene predicted gene, 46690 Neighboring gene FYVE, RhoGEF and PH domain containing 1 Neighboring gene TSR2 20S rRNA accumulation

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GNL3L inhibits activity of estrogen-related receptor gamma by competing for coactivator binding. Yasumoto H, et al. J Cell Sci, 2007 Aug 1. PMID 17623774, Free PMC Article
    2. GNL3L stabilizes the TRF1 complex and promotes mitotic transition. Zhu Q, et al. J Cell Biol, 2009 Jun 1. PMID 19487455, Free PMC Article
    3. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article
    4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    5. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of GNL3L Alleviates the Progression of COPD Through Inhibiting the ATM/p53 Pathway.
      Title: Knockdown of GNL3L Alleviates the Progression of COPD Through Inhibiting the ATM/p53 Pathway.
    2. GNL3L mediates the mitotic increase of TRF1 protein and promotes the metaphase-to-anaphase transition.
      Title: GNL3L stabilizes the TRF1 complex and promotes mitotic transition.
    3. work reveals a novel mechanism that negatively regulates the transcriptional function of ERRgamma (estrogen-related receptor)by GNL3L through coactivator competition.
      Title: GNL3L inhibits activity of estrogen-related receptor gamma by competing for coactivator binding.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein-like 3-like protein
    Names
    guanine nucleotide binding protein-like 3 (nucleolar)-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168600.1 → NP_001162071.1  guanine nucleotide-binding protein-like 3-like protein

      See identical proteins and their annotated locations for NP_001162071.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL805937, BY640210, CJ066167
      Consensus CDS
      CCDS41174.1
      UniProtKB/Swiss-Prot
      Q6PGG6
      Related
      ENSMUSP00000026297.6, ENSMUST00000026297.12
      Conserved Domains (3) summary
      PTZ00121
      Location:19 → 166
      PTZ00121; MAEBL; Provisional
      cd04178
      Location:129 → 301
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG0012
      Location:246 → 384
      GTP1; Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis]

    2. NM_198110.2 → NP_932778.1  guanine nucleotide-binding protein-like 3-like protein

      See identical proteins and their annotated locations for NP_932778.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2)represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BB644039, BC057033, BY640210
      Consensus CDS
      CCDS41174.1
      UniProtKB/Swiss-Prot
      Q6PGG6
      Related
      ENSMUSP00000108311.3, ENSMUST00000112691.9
      Conserved Domains (3) summary
      PTZ00121
      Location:19 → 166
      PTZ00121; MAEBL; Provisional
      cd04178
      Location:129 → 301
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG0012
      Location:246 → 384
      GTP1; Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      149766129..149800318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528805.5 → XP_006528868.1  guanine nucleotide-binding protein-like 3-like protein isoform X1

      See identical proteins and their annotated locations for XP_006528868.1

      UniProtKB/Swiss-Prot
      Q6PGG6
      Conserved Domains (3) summary
      PTZ00121
      Location:19 → 166
      PTZ00121; MAEBL; Provisional
      cd04178
      Location:129 → 301
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG0012
      Location:246 → 384
      GTP1; Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PGG6.1 GenPept UniProtKB/Swiss-Prot:Q6PGG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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