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    Aar2 AAR2 splicing factor homolog [ Mus musculus (house mouse) ]

    Gene ID: 68295, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Aar2provided by MGI
    Official Full Name
    AAR2 splicing factor homologprovided by MGI
    Primary source
    MGI:MGI:1915545
    See related
    Ensembl:ENSMUSG00000027628 AllianceGenome:MGI:1915545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610011L14Rik
    Summary
    Predicted to be involved in spliceosomal tri-snRNP complex assembly. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be part of spliceosomal complex. Is expressed in gonad. Orthologous to human AAR2 (AAR2 splicing factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 10.4), ovary adult (RPKM 9.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H1; 2 77.54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156389496..156410892)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156547560..156568972)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37a pseudogene Neighboring gene erythrocyte membrane protein band 4.1 like 1 Neighboring gene STARR-seq mESC enhancer starr_06170 Neighboring gene STARR-seq mESC enhancer starr_06171 Neighboring gene predicted gene, 33977 Neighboring gene STARR-seq mESC enhancer starr_06172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156373177-156373360 Neighboring gene predicted gene 14169 Neighboring gene DLG associated protein 4 Neighboring gene predicted gene 14172

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A proteomics strategy for the enrichment of receptor-associated complexes. Cross M, et al. Proteomics, 2005 Dec. PMID 16267818
    2. Large-scale screen for genes involved in gonad development. Wertz K, et al. Mech Dev, 2000 Nov. PMID 11044607
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein AAR2 homolog
    Names
    novel transcript

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164818.1 → NP_001158290.1  protein AAR2 homolog

      See identical proteins and their annotated locations for NP_001158290.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK028890, AK169526, CJ152371
      Consensus CDS
      CCDS16967.1
      UniProtKB/Swiss-Prot
      Q3TEN8, Q3TM16, Q8VBU9, Q9D2V5
      UniProtKB/TrEMBL
      Q8C161
      Related
      ENSMUSP00000105198.2, ENSMUST00000109570.8
      Conserved Domains (1) summary
      pfam05282
      Location:17 → 363
      AAR2; AAR2 protein

    2. NM_026661.4 → NP_080937.3  protein AAR2 homolog

      See identical proteins and their annotated locations for NP_080937.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      AK018741, AK028890, CJ152371
      Consensus CDS
      CCDS16967.1
      UniProtKB/Swiss-Prot
      Q3TEN8, Q3TM16, Q8VBU9, Q9D2V5
      UniProtKB/TrEMBL
      Q8C161
      Related
      ENSMUSP00000029158.4, ENSMUST00000029158.4
      Conserved Domains (1) summary
      pfam05282
      Location:17 → 363
      AAR2; AAR2 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      156389496..156410892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500097.5 → XP_006500160.1  protein AAR2 homolog isoform X1

      See identical proteins and their annotated locations for XP_006500160.1

      UniProtKB/Swiss-Prot
      Q3TEN8, Q3TM16, Q8VBU9, Q9D2V5
      UniProtKB/TrEMBL
      Q8C161
      Conserved Domains (1) summary
      pfam05282
      Location:17 → 363
      AAR2; AAR2 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2V5.3 GenPept UniProtKB/Swiss-Prot:Q9D2V5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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