U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Kdm2b lysine (K)-specific demethylase 2B [ Mus musculus (house mouse) ]

    Gene ID: 30841, updated on 23-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Kdm2bprovided by MGI
    Official Full Name
    lysine (K)-specific demethylase 2Bprovided by MGI
    Primary source
    MGI:MGI:1354737
    See related
    Ensembl:ENSMUSG00000029475 AllianceGenome:MGI:1354737
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cxxc2; Fbl10; PCCX2; Fbxl10; Jhdm1b
    Summary
    The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 10.9), whole brain E14.5 (RPKM 10.7) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    5 F; 5 62.63 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123008727..123127333, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122870664..122989270, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2762 Neighboring gene predicted gene, 33044 Neighboring gene ring finger protein 34 Neighboring gene STARR-seq mESC enhancer starr_14301 Neighboring gene STARR-positive B cell enhancer ABC_E3615 Neighboring gene predicted gene, 33118 Neighboring gene RIKEN cDNA A930024E05 gene Neighboring gene STARR-seq mESC enhancer starr_14304 Neighboring gene STARR-positive B cell enhancer ABC_E3616 Neighboring gene predicted gene 2479

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Impaired KDM2B-mediated PRC1 recruitment to chromatin causes defective neural stem cell self-renewal and ASD/ID-like behaviors. Gao Y, et al. iScience, 2022 Feb 18. PMID 35128353, Free PMC Article
    2. Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells. Deiktakis EE, et al. Protein J, 2020 Jun. PMID 32270414
    3. Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts. Rohde M, et al. Exp Cell Res, 2016 Nov 1. PMID 27646113
    4. Abnormal X chromosome inactivation and sex-specific gene dysregulation after ablation of FBXL10. Boulard M, et al. Epigenetics Chromatin, 2016. PMID 27252784, Free PMC Article
    5. Enhanced direct conversion of fibroblasts into hepatocyte-like cells by Kdm2b. Zakikhan K, et al. Biochem Biophys Res Commun, 2016 May 20. PMID 27103435

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.
      Title: KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.
    2. KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling.
      Title: KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling.
    3. Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.
      Title: Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.
    4. Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b.
      Title: Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b.
    5. KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.
      Title: KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.
    6. KDM2 proteins play a widespread and demethylase-independent role in constraining gene expression from CpG islands CGI)-associated gene promoters. KDM2 proteins shape RNA Polymerase II occupancy but not chromatin accessibility at CGI-associated promoters.
      Title: KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity.
    7. tthat bone morphogenetic protein (BMP) represses Oct4/Kdm2b-induced somatic reprogramming selectively
      Title: Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function.
    8. Fbxl10 plays a critical role in migration by binding to the promoter region of migration-associated genes and thereby might influences cell behaviour to a possibly more aggressive phenotype.
      Title: Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts.
    9. These results have not only identified an important epigenetic factor for iHep generation, but also brought new insight into the molecular nature of hepatogenesis and future biomedical applications for liver diseases.
      Title: Enhanced direct conversion of fibroblasts into hepatocyte-like cells by Kdm2b.
    10. this study shows that long noncoding RNA Kdm2b expression sustains the maintenance of Innate lymphoid cells by promoting their proliferation through activation of the transcription factor Zfp292
      Title: Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA3014, E430001G17

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K36 demethylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K36me/H3K36me2 demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone demethylase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unmethylated CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fourth ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in initiation of neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lateral ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in midbrain-hindbrain boundary morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of stem cell population maintenance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in third ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lysine-specific demethylase 2B
    Names
    F-box and leucine-rich repeat protein 10
    F-box protein FBL10
    F-box protein containing leucine repeats 10
    F-box/LRR-repeat protein 10
    [Histone-H3]-lysine-36 demethylase 1B
    jmjC domain-containing histone demethylation protein 1B
    NP_001003953.1
    NP_001365792.1
    NP_001365793.1
    NP_001365794.1
    NP_038938.1
    XP_006530439.1
    XP_011246510.1
    XP_011246511.1
    XP_011246512.1
    XP_011246513.1
    XP_011246514.1
    XP_011246515.1
    XP_011246516.1
    XP_011246517.1
    XP_011246518.1
    XP_036021058.1
    XP_036021059.1
    XP_036021060.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003953.2 → NP_001003953.1  lysine-specific demethylase 2B isoform 1

      See identical proteins and their annotated locations for NP_001003953.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK136625, BC065090
      Consensus CDS
      CCDS39259.1
      UniProtKB/Swiss-Prot
      Q3V396, Q6P1G2, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6
      UniProtKB/TrEMBL
      D3YVU7
      Related
      ENSMUSP00000038229.10, ENSMUST00000046073.16
      Conserved Domains (7) summary
      cd09293
      Location:1080 → 1280
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151 → 226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam02008
      Location:588 → 624
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:1075 → 1099
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:634 → 695
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:1041 → 1081
      F-box-like; F-box-like
      cl21464
      Location:198 → 304
      cupin_like; Conserved domain found in cupin and related proteins

    2. NM_001378863.1 → NP_001365792.1  lysine-specific demethylase 2B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC121564
      UniProtKB/TrEMBL
      D3YVU7, E9QL25
      Related
      ENSMUSP00000083376.5, ENSMUST00000086200.11
      Conserved Domains (10) summary
      PTZ00449
      Location:687 → 986
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:1074 → 1274
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:145 → 220
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1069 → 1093
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:628 → 689
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:582 → 618
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:1035 → 1073
      F-box-like
      pfam17811
      Location:297 → 332
      JHD; Jumonji helical domain
      cl40423
      Location:192 → 298
      cupin_RmlC-like; RmlC-like cupin superfamily
      cl40435
      Location:474 → 540
      CTD_KDM2A_2B-like; C-terminal domain found in lysine-specific demethylase KDM2A, KDM2B, and similar proteins

    3. NM_001378864.1 → NP_001365793.1  lysine-specific demethylase 2B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC121564
      Conserved Domains (6) summary
      PTZ00449
      Location:160 → 462
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:561 → 750
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:545 → 569
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:101 → 162
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:55 → 91
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:511 → 549
      F-box-like

    4. NM_001378865.1 → NP_001365794.1  lysine-specific demethylase 2B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC121564
      Conserved Domains (5) summary
      cd09293
      Location:520 → 709
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:504 → 528
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:101 → 162
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:55 → 91
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:470 → 508
      F-box-like

    5. NM_013910.2 → NP_038938.1  lysine-specific demethylase 2B isoform 2

      See identical proteins and their annotated locations for NP_038938.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks exons in the 5' UTR and 5' coding region and uses an alternate 5' terminal exon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC057622, BC065090, BU841175
      Consensus CDS
      CCDS19657.1
      UniProtKB/Swiss-Prot
      Q6P1G2
      Related
      ENSMUSP00000031435.8, ENSMUST00000031435.14
      Conserved Domains (5) summary
      cd09293
      Location:558 → 747
      AMN1; Antagonist of mitotic exit network protein 1
      pfam02008
      Location:55 → 91
      zf-CXXC; CXXC zinc finger domain
      sd00034
      Location:542 → 566
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:101 → 162
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam12937
      Location:508 → 548
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      123008727..123127333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530376.4 → XP_006530439.1  lysine-specific demethylase 2B isoform X4

      UniProtKB/TrEMBL
      D3YVU4
      Related
      ENSMUSP00000114052.3, ENSMUST00000118027.8
      Conserved Domains (9) summary
      cd09293
      Location:1042 → 1242
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151 → 226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1037 → 1061
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:634 → 695
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:588 → 624
      zf-CXXC; CXXC zinc finger domain
      pfam10477
      Location:718 → 922
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
      pfam12937
      Location:1003 → 1041
      F-box-like
      pfam17811
      Location:303 → 338
      JHD; Jumonji helical domain
      cl21464
      Location:198 → 297
      cupin_like; Conserved domain found in cupin and related proteins

    2. XM_011248210.3 → XP_011246512.1  lysine-specific demethylase 2B isoform X3

      UniProtKB/TrEMBL
      D3YVU4
      Conserved Domains (9) summary
      cd09293
      Location:1045 → 1245
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151 → 226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1040 → 1064
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:634 → 695
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:588 → 624
      zf-CXXC; CXXC zinc finger domain
      pfam10477
      Location:721 → 925
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
      pfam12937
      Location:1006 → 1044
      F-box-like
      pfam17811
      Location:303 → 338
      JHD; Jumonji helical domain
      cl21464
      Location:198 → 297
      cupin_like; Conserved domain found in cupin and related proteins

    3. XM_011248208.3 → XP_011246510.1  lysine-specific demethylase 2B isoform X1

      UniProtKB/TrEMBL
      D3YVU7
      Conserved Domains (9) summary
      PTZ00449
      Location:693 → 995
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:1083 → 1283
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151 → 226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1078 → 1102
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:634 → 695
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:588 → 624
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:1044 → 1082
      F-box-like
      pfam17811
      Location:303 → 338
      JHD; Jumonji helical domain
      cl21464
      Location:198 → 297
      cupin_like; Conserved domain found in cupin and related proteins

    4. XM_011248212.4 → XP_011246514.1  lysine-specific demethylase 2B isoform X5

      See identical proteins and their annotated locations for XP_011246514.1

      UniProtKB/TrEMBL
      D3YVU7
      Related
      ENSMUSP00000114049.2, ENSMUST00000121739.8
      Conserved Domains (9) summary
      PTZ00449
      Location:638 → 940
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:1028 → 1228
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:96 → 171
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1023 → 1047
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:579 → 640
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:533 → 569
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:989 → 1027
      F-box-like
      pfam17811
      Location:248 → 283
      JHD; Jumonji helical domain
      cl21464
      Location:143 → 242
      cupin_like; Conserved domain found in cupin and related proteins

    5. XM_011248211.4 → XP_011246513.1  lysine-specific demethylase 2B isoform X5

      See identical proteins and their annotated locations for XP_011246513.1

      UniProtKB/TrEMBL
      D3YVU7
      Conserved Domains (9) summary
      PTZ00449
      Location:638 → 940
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:1028 → 1228
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:96 → 171
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1023 → 1047
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:579 → 640
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:533 → 569
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:989 → 1027
      F-box-like
      pfam17811
      Location:248 → 283
      JHD; Jumonji helical domain
      cl21464
      Location:143 → 242
      cupin_like; Conserved domain found in cupin and related proteins

    6. XM_011248209.4 → XP_011246511.1  lysine-specific demethylase 2B isoform X2

      UniProtKB/TrEMBL
      D3YVU7
      Conserved Domains (9) summary
      PTZ00449
      Location:687 → 989
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:1077 → 1277
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:145 → 220
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1072 → 1096
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:628 → 689
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:582 → 618
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:1038 → 1076
      F-box-like
      pfam17811
      Location:297 → 332
      JHD; Jumonji helical domain
      cl21464
      Location:192 → 291
      cupin_like; Conserved domain found in cupin and related proteins

    7. XM_011248215.2 → XP_011246517.1  lysine-specific demethylase 2B isoform X8

      UniProtKB/TrEMBL
      D3YVU7
      Conserved Domains (9) summary
      PTZ00449
      Location:607 → 909
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:997 → 1197
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:65 → 140
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:992 → 1016
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:548 → 609
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:502 → 538
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:958 → 996
      F-box-like
      pfam17811
      Location:217 → 252
      JHD; Jumonji helical domain
      cl21464
      Location:112 → 211
      cupin_like; Conserved domain found in cupin and related proteins

    8. XM_036165165.1 → XP_036021058.1  lysine-specific demethylase 2B isoform X7

      UniProtKB/TrEMBL
      D3YVU7
      Conserved Domains (9) summary
      PTZ00449
      Location:493 → 792
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:880 → 1080
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:875 → 899
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:434 → 495
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:388 → 424
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:841 → 879
      F-box-like
      pfam17811
      Location:103 → 138
      JHD; Jumonji helical domain
      cd21785
      Location:280 → 346
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
      cl40423
      Location:1 → 104
      cupin_RmlC-like; RmlC-like cupin superfamily

    9. XM_011248214.3 → XP_011246516.1  lysine-specific demethylase 2B isoform X6

      See identical proteins and their annotated locations for XP_011246516.1

      UniProtKB/TrEMBL
      D3YVU7
      Conserved Domains (8) summary
      PTZ00449
      Location:493 → 795
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:883 → 1083
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:878 → 902
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:434 → 495
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:388 → 424
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:844 → 882
      F-box-like
      pfam17811
      Location:103 → 138
      JHD; Jumonji helical domain
      cl21464
      Location:1 → 97
      cupin_like; Conserved domain found in cupin and related proteins

    10. XM_011248213.4 → XP_011246515.1  lysine-specific demethylase 2B isoform X6

      See identical proteins and their annotated locations for XP_011246515.1

      UniProtKB/TrEMBL
      D3YVU7
      Conserved Domains (8) summary
      PTZ00449
      Location:493 → 795
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:883 → 1083
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:878 → 902
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:434 → 495
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:388 → 424
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:844 → 882
      F-box-like
      pfam17811
      Location:103 → 138
      JHD; Jumonji helical domain
      cl21464
      Location:1 → 97
      cupin_like; Conserved domain found in cupin and related proteins

    11. XM_011248216.3 → XP_011246518.1  lysine-specific demethylase 2B isoform X6

      See identical proteins and their annotated locations for XP_011246518.1

      UniProtKB/TrEMBL
      D3YVU7
      Conserved Domains (8) summary
      PTZ00449
      Location:493 → 795
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:883 → 1083
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:878 → 902
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:434 → 495
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:388 → 424
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:844 → 882
      F-box-like
      pfam17811
      Location:103 → 138
      JHD; Jumonji helical domain
      cl21464
      Location:1 → 97
      cupin_like; Conserved domain found in cupin and related proteins

    12. XM_036165167.1 → XP_036021060.1  lysine-specific demethylase 2B isoform X10

      Conserved Domains (7) summary
      PTZ00449
      Location:363 → 662
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:750 → 950
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:745 → 769
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:304 → 365
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:258 → 294
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:711 → 749
      F-box-like
      cd21785
      Location:150 → 216
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B

    13. XM_036165166.1 → XP_036021059.1  lysine-specific demethylase 2B isoform X9

      Conserved Domains (7) summary
      PTZ00449
      Location:363 → 665
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09293
      Location:753 → 953
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:748 → 772
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:304 → 365
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:258 → 294
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:714 → 752
      F-box-like
      cd21785
      Location:150 → 216
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001005866.1: Suppressed sequence

      Description
      NM_001005866.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1G2.1 GenPept UniProtKB/Swiss-Prot:Q6P1G2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous