Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpina3nprovided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade A, member 3Nprovided by MGI
Primary source: MGI:MGI:105045
See related: Ensembl:ENSMUSG00000021091 AllianceGenome:MGI:105045
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spi2-2; Spi2.2; Spi2/eb.4
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to bacterium; response to cytokine; and response to peptide hormone. Located in extracellular region. Is expressed in several structures, including ganglia; hindbrain; skeleton; thymus primordium; and urinary system. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 296.6), liver adult (RPKM 171.8) and 7 other tissues See more
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Genomic context

Location:: 12 E; 12 54.17 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (104372967..104380588)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (104406646..104414334)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SerpinA3N Regulates the Secretory Phenotype of Mouse Senescent Astrocytes Contributing to Neurodegeneration.
Title: SerpinA3N Regulates the Secretory Phenotype of Mouse Senescent Astrocytes Contributing to Neurodegeneration.
Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-kappaB signaling pathway in mice with temporal lobe epilepsy.
Title: Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy.
SerpinA3N deficiency attenuates steatosis and enhances insulin signaling in male mice.
Title: SerpinA3N deficiency attenuates steatosis and enhances insulin signaling in male mice.
Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke.
Title: Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke.
Downregulation of Sepina3n Aggravated Blood-Brain Barrier Disruption after Traumatic Brain Injury by Activating Neutrophil Elastase in Mice.
Title: Downregulation of Sepina3n Aggravated Blood-Brain Barrier Disruption after Traumatic Brain Injury by Activating Neutrophil Elastase in Mice.
Serpin Signatures in Prion and Alzheimer's Diseases.
Title: Serpin Signatures in Prion and Alzheimer's Diseases.
SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation.
Title: SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation.
Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model.
Title: Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model.
SerpinA3n affects ovalbumin (OVA)-induced asthma in neonatal mice via the regulation of collagen deposition and inflammatory response.
Title: SerpinA3n affects ovalbumin (OVA)-induced asthma in neonatal mice via the regulation of collagen deposition and inflammatory response.
Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta.
Title: Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cytokine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine protease inhibitor A3N

Names: alpha-1 antiproteinase; antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 3N; serine protease inhibitor 2-2; serpin A3N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009252.2 → NP_033278.2 serine protease inhibitor A3N precursor

See identical proteins and their annotated locations for NP_033278.2

Status: VALIDATED

Source sequence(s)

AC117194

Consensus CDS

CCDS26152.1

UniProtKB/Swiss-Prot

Q62258, Q91WP6

UniProtKB/TrEMBL

G3X8T9

Related

ENSMUSP00000021506.6, ENSMUST00000021506.6

Conserved Domains (1) summary

cd19551
Location:37 → 418

serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin