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    Dock4 dedicator of cytokinesis 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366608, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Dock4provided by RGD
    Official Full Name
    dedicator of cytokinesis 4provided by RGD
    Primary source
    RGD:1561724
    See related
    Ensembl:ENSRNOG00000004823 AllianceGenome:RGD:1561724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in cell chemotaxis; negative regulation of vascular associated smooth muscle contraction; and positive regulation of vascular associated smooth muscle cell migration. Predicted to be located in several cellular components, including Golgi apparatus; nucleolus; and stereocilium. Orthologous to human DOCK4 (dedicator of cytokinesis 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 188.1), Brain (RPKM 147.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q21
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (63240050..63629772)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (57512929..57902597)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (60374839..60782648)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L29-like Neighboring gene interferon-related developmental regulator 1 Neighboring gene uncharacterized LOC120093202 Neighboring gene zinc finger protein 277 Neighboring gene uncharacterized LOC102552766 Neighboring gene inner mitochondrial membrane peptidase subunit 2 Neighboring gene H3.3 histone like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dock4 regulates dendritic development in hippocampal neurons. Ueda S, et al. J Neurosci Res, 2008 Nov 1. PMID 18615735
    2. Direct targeting of DOCK4 by miRNA-181d in oxygen-glucose deprivation/reoxygenation-mediated neuronal injury. Li S, et al. Lipids Health Dis, 2023 Mar 7. PMID 36882763, Free PMC Article
    3. Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation. Ueda S, et al. Mol Biol Cell, 2013 May. PMID 23536706, Free PMC Article
    4. An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C). Yan D, et al. J Mol Biol, 2006 Mar 31. PMID 16464467
    5. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. Kang H, et al. J Biol Chem, 2012 Feb 3. PMID 22158624, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Direct targeting of DOCK4 by miRNA-181d in oxygen-glucose deprivation/reoxygenation-mediated neuronal injury.
      Title: Direct targeting of DOCK4 by miRNA-181d in oxygen-glucose deprivation/reoxygenation-mediated neuronal injury.
    2. a new function of the Rac activator Dock4 in dendritic morphogenesis in hippocampal neurons
      Title: Dock4 regulates dendritic development in hippocampal neurons.
    3. Dock4 is highly concentrated in dendritic spines and implicated in spine formation via interaction with the actin-binding protein cortactin.
      Title: Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of vascular associated smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium bundle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427091.1 → NP_001414020.1  dedicator of cytokinesis protein 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZNR8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      63240050..63629772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078130.2 → XP_038934058.1  dedicator of cytokinesis protein 4 isoform X5

      UniProtKB/TrEMBL
      A6HBD9
      Conserved Domains (4) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus
      cl06123
      Location:1187 → 1227
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    2. XM_039078128.2 → XP_038934056.1  dedicator of cytokinesis protein 4 isoform X3

      UniProtKB/TrEMBL
      F1LZ81
      Conserved Domains (4) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1206 → 1596
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    3. XM_039078129.2 → XP_038934057.1  dedicator of cytokinesis protein 4 isoform X4

      UniProtKB/TrEMBL
      F1LZ81, M0R6K4
      Related
      ENSRNOP00000065056.3
      Conserved Domains (4) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1206 → 1596
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    4. XM_039078126.2 → XP_038934054.1  dedicator of cytokinesis protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZXG8, F1LZ81
      Related
      ENSRNOP00000083690.1
      Conserved Domains (4) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1197 → 1587
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    5. XM_039078125.1 → XP_038934053.1  dedicator of cytokinesis protein 4 isoform X1

      UniProtKB/TrEMBL
      F1LZ81
      Related
      ENSRNOP00000006709.8, ENSRNOT00000006709.9
      Conserved Domains (4) summary
      cd08695
      Location:399 → 583
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1205 → 1595
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:9 → 64
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:68 → 391
      DOCK_N; DOCK N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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