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    Ndor1 NADPH dependent diflavin oxidoreductase 1 [ Mus musculus (house mouse) ]

    Gene ID: 78797, updated on 4-Jun-2024

    Summary

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    Official Symbol
    Ndor1provided by MGI
    Official Full Name
    NADPH dependent diflavin oxidoreductase 1provided by MGI
    Primary source
    MGI:MGI:1926047
    See related
    Ensembl:ENSMUSG00000006471 Ensembl:ENSMUSG00000115074 AllianceGenome:MGI:1926047
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NR1; Ndor; Ubc-cre; 4930447P04Rik; Tg(UBC-cre/ERT2)1Ejb
    Summary
    Predicted to enable several functions, including NADPH-hemoprotein reductase activity; nucleotide binding activity; and oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor. Predicted to be involved in cell death; cellular response to menadione; and electron transport chain. Predicted to be located in cytoplasm; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be active in cytosol. Orthologous to human NDOR1 (NADPH dependent diflavin oxidoreductase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 16.6), spleen adult (RPKM 13.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndor1 in Genome Data Viewer
    Location:
    2 A3; 2 17.1 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25134825..25145458, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25244813..25255509, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cysteine rich tail 1 Neighboring gene ring finger protein 208 Neighboring gene transmembrane protein 203 Neighboring gene STARR-positive B cell enhancer ABC_E805 Neighboring gene taperin Neighboring gene SS nuclear autoantigen 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multicolor fate mapping of Langerhans cell homeostasis. Ghigo C, et al. J Exp Med, 2013 Aug 26. PMID 23940255, Free PMC Article
    2. Generation of a tamoxifen inducible SMN mouse for temporal SMN replacement. Bebee TW, et al. Genesis, 2011 Dec. PMID 21538807
    3. Allelic contribution of Nrxn1α to autism-relevant behavioral phenotypes in mice. Xu B, et al. PLoS Genet, 2023 Feb. PMID 36848371, Free PMC Article
    4. Evidence of shared transcriptomic dysregulation of HNRNPU-related disorder between human organoids and embryonic mice. Ressler AK, et al. iScience, 2023 Jan 20. PMID 36594023, Free PMC Article
    5. The nuclear factor of activated T cells 5 (NFAT5) contributes to the renal corticomedullary differences in gene expression. Chernyakov D, et al. Sci Rep, 2022 Nov 24. PMID 36433977, Free PMC Article

    See all (472) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH-hemoprotein reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables electron transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NADPH-dependent diflavin oxidoreductase 1
    Names
    NADPH-dependent FMN and FAD-containing oxidoreductase
    Tg(UBC-cre)1Ejb
    Tg(UBC-cre/ESR1)1Ejb
    NP_001075945.1
    NP_001239470.1
    NP_001239471.1
    XP_006498504.1
    XP_006498505.1
    XP_006498506.1
    XP_006498507.1
    XP_006498508.1
    XP_006498509.1
    XP_006498510.1
    XP_006498511.1
    XP_006498513.1
    XP_006498514.1
    XP_006498515.1
    XP_006498518.1
    XP_030108111.1
    XP_030108112.1
    XP_030108113.1
    XP_036018619.1
    XP_036018620.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082476.2 → NP_001075945.1  NADPH-dependent diflavin oxidoreductase 1 isoform 1

      See identical proteins and their annotated locations for NP_001075945.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK019617, AL732309
      Consensus CDS
      CCDS38069.1
      UniProtKB/Swiss-Prot
      A2AI05, Q3TQZ6, Q80WC5
      Related
      ENSMUSP00000109989.3, ENSMUST00000114349.9
      Conserved Domains (3) summary
      COG0369
      Location:6 → 597
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:8 → 145
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:212 → 597
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    2. NM_001252541.1 → NP_001239470.1  NADPH-dependent diflavin oxidoreductase 1 isoform 2

      See identical proteins and their annotated locations for NP_001239470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK163207, AL732309
      Consensus CDS
      CCDS57157.1
      UniProtKB/Swiss-Prot
      A2AI05
      Related
      ENSMUSP00000097903.4, ENSMUST00000100329.10
      Conserved Domains (3) summary
      COG0369
      Location:6 → 530
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:8 → 123
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:145 → 530
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    3. NM_001252542.1 → NP_001239471.1  NADPH-dependent diflavin oxidoreductase 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK143124, AL732309
      Consensus CDS
      CCDS89442.1
      UniProtKB/TrEMBL
      A0A2I3BQN1
      Related
      ENSMUSP00000154261.2, ENSMUST00000228052.2
      Conserved Domains (3) summary
      COG0369
      Location:1 → 450
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:1 → 76
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:143 → 450
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25134825..25145458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498446.5 → XP_006498509.1  NADPH-dependent diflavin oxidoreductase 1 isoform X5

      Conserved Domains (1) summary
      COG0369
      Location:6 → 519
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    2. XM_036162726.1 → XP_036018619.1  NADPH-dependent diflavin oxidoreductase 1 isoform X11

      Conserved Domains (1) summary
      COG0369
      Location:6 → 551
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    3. XM_006498455.5 → XP_006498518.1  NADPH-dependent diflavin oxidoreductase 1 isoform X14

      Conserved Domains (1) summary
      COG0369
      Location:98 → 570
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    4. XM_006498441.5 → XP_006498504.1  NADPH-dependent diflavin oxidoreductase 1 isoform X1

      Conserved Domains (1) summary
      COG0369
      Location:98 → 570
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    5. XM_006498451.5 → XP_006498514.1  NADPH-dependent diflavin oxidoreductase 1 isoform X8

      See identical proteins and their annotated locations for XP_006498514.1

      Conserved Domains (1) summary
      COG0369
      Location:98 → 570
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    6. XM_006498450.5 → XP_006498513.1  NADPH-dependent diflavin oxidoreductase 1 isoform X8

      See identical proteins and their annotated locations for XP_006498513.1

      Conserved Domains (1) summary
      COG0369
      Location:98 → 570
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    7. XM_006498447.5 → XP_006498510.1  NADPH-dependent diflavin oxidoreductase 1 isoform X6

      Conserved Domains (1) summary
      COG0369
      Location:98 → 602
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    8. XM_006498445.5 → XP_006498508.1  NADPH-dependent diflavin oxidoreductase 1 isoform X4

      See identical proteins and their annotated locations for XP_006498508.1

      Conserved Domains (1) summary
      COG0369
      Location:98 → 602
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    9. XM_006498444.5 → XP_006498507.1  NADPH-dependent diflavin oxidoreductase 1 isoform X4

      See identical proteins and their annotated locations for XP_006498507.1

      Conserved Domains (1) summary
      COG0369
      Location:98 → 602
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    10. XM_006498452.4 → XP_006498515.1  NADPH-dependent diflavin oxidoreductase 1 isoform X10

      Conserved Domains (2) summary
      pfam00258
      Location:1 → 76
      Flavodoxin_1
      cl06868
      Location:143 → 450
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    11. XM_030252252.2 → XP_030108112.1  NADPH-dependent diflavin oxidoreductase 1 isoform X13

      Conserved Domains (1) summary
      cl06868
      Location:59 → 366
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    12. XM_006498448.5 → XP_006498511.1  NADPH-dependent diflavin oxidoreductase 1 isoform X7

      Conserved Domains (1) summary
      COG0369
      Location:25 → 497
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    13. XM_030252253.2 → XP_030108113.1  NADPH-dependent diflavin oxidoreductase 1 isoform X13

      Conserved Domains (1) summary
      cl06868
      Location:59 → 366
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    14. XM_006498442.5 → XP_006498505.1  NADPH-dependent diflavin oxidoreductase 1 isoform X2

      Conserved Domains (1) summary
      COG0369
      Location:98 → 570
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    15. XM_036162727.1 → XP_036018620.1  NADPH-dependent diflavin oxidoreductase 1 isoform X12

      Conserved Domains (2) summary
      pfam00258
      Location:1 → 76
      Flavodoxin_1
      cl06868
      Location:143 → 528
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    16. XM_006498443.5 → XP_006498506.1  NADPH-dependent diflavin oxidoreductase 1 isoform X3

      Conserved Domains (1) summary
      COG0369
      Location:98 → 648
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    17. XM_030252251.2 → XP_030108111.1  NADPH-dependent diflavin oxidoreductase 1 isoform X9

      Conserved Domains (1) summary
      COG0369
      Location:25 → 575
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

    RNA

    1. XR_004940781.1 RNA Sequence

    2. XR_004940780.1 RNA Sequence

    3. XR_004940779.1 RNA Sequence

    4. XR_004940778.1 RNA Sequence

    5. XR_004940777.1 RNA Sequence

    6. XR_374139.5 RNA Sequence

    7. XR_374138.5 RNA Sequence

    8. XR_003953749.2 RNA Sequence

    9. XR_866029.4 RNA Sequence

    10. XR_866028.4 RNA Sequence

    11. XR_374141.5 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178239.2: Suppressed sequence

      Description
      NM_178239.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AI05.1 GenPept UniProtKB/Swiss-Prot:A2AI05

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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