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    LTK leukocyte receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 4058, updated on 11-Apr-2024

    Summary

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    Official Symbol
    LTKprovided by HGNC
    Official Full Name
    leukocyte receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:6721
    See related
    Ensembl:ENSG00000062524 MIM:151520; AllianceGenome:HGNC:6721
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TYK1
    Summary
    The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
    Expression
    Broad expression in duodenum (RPKM 6.4), lung (RPKM 6.1) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LTK in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41503637..41513827, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39309799..39319984, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41795835..41806025, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RTF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene uncharacterized LOC105370790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9282 Neighboring gene Sharpr-MPRA regulatory region 6351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41784974-41785474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41785475-41785975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6361 Neighboring gene inositol-trisphosphate 3-kinase A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41804857-41805604 Neighboring gene RNA polymerase II associated protein 1 Neighboring gene MPRA-validated peak2307 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41835695-41836276 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:41844728-41844829 Neighboring gene elongin C pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LTK is an ER-resident receptor tyrosine kinase that regulates secretion. Centonze FG, et al. J Cell Biol, 2019 Aug 5. PMID 31227593, Free PMC Article
    2. ALK-activating homologous mutations in LTK induce cellular transformation. Roll JD, et al. PLoS One, 2012. PMID 22347506, Free PMC Article
    3. Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase. Ueno H, et al. J Biol Chem, 1996 Nov 1. PMID 8910363
    4. Identification of the human ltk gene product in placenta and hematopoietic cell lines. Kozutsumi H, et al. Biochem Biophys Res Commun, 1993 Jan 29. PMID 8427607
    5. Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein. Toyoshima H, et al. Proc Natl Acad Sci U S A, 1993 Jun 15. PMID 7685902, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spindle cell neoplasms with novel LTK fusion - Expanding the spectrum of kinase fusion-positive soft tissue tumors.
      Title: Spindle cell neoplasms with novel LTK fusion - Expanding the spectrum of kinase fusion-positive soft tissue tumors.
    2. The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer.
      Title: The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer.
    3. Structural basis of cytokine-mediated activation of ALK family receptors.
      Title: Structural basis of cytokine-mediated activation of ALK family receptors.
    4. LTK-to-Sec12 signaling represents the first example of an endoplasmic reticulum-resident signaling module with the potential to regulate proteostasis.
      Title: LTK is an ER-resident receptor tyrosine kinase that regulates secretion.
    5. Data show FAM150B, which was named as augmentor-alpha (AUG-alpha), binds and activtes both anaplastic lymphoma kinase (ALK) and tyrosine kinase (LTK).
      Title: Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.
    6. Only two related secreted factors, FAM150A and FAM150B (family with sequence similarity 150 member A and member B), stimulated LTK phosphorylation.
      Title: Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.
    7. aberrant activation of LTK may contribute to neoplastic cell growth.
      Title: ALK-activating homologous mutations in LTK induce cellular transformation.
    8. polymorphic LTKs cause up-regulation of the PI3K pathway and possibly form one genetic component of susceptibility to abnormal proliferation of self-reactive B cells in systemic lupus erythematosus
      Title: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables receptor signaling protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cardiac muscle cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte tyrosine kinase receptor
    Names
    protein tyrosine kinase 1
    NP_001129157.1
    NP_002335.2
    NP_996844.1
    XP_011519859.1
    XP_024305687.2
    XP_047288455.1
    XP_047288456.1
    XP_047288457.1
    XP_047288458.1
    XP_047288459.1
    XP_047288461.1
    XP_047288462.1
    XP_054233880.1
    XP_054233881.1
    XP_054233882.1
    XP_054233883.1
    XP_054233884.1
    XP_054233885.1
    XP_054233886.1
    XP_054233887.1
    XP_054233888.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135685.2 → NP_001129157.1  leukocyte tyrosine kinase receptor isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two internal coding exons and uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (3) is missing two internal segments and has a short segment in an alternate reading frame but with the same N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC016134, AC087721, AK296892, CA394397
      Consensus CDS
      CCDS45237.1
      UniProtKB/Swiss-Prot
      P29376
      Related
      ENSP00000392196.2, ENST00000453182.2
      Conserved Domains (2) summary
      pfam07714
      Location:415 → 647
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:414 → 649
      PKc_like; Protein Kinases, catalytic domain

    2. NM_002344.6 → NP_002335.2  leukocyte tyrosine kinase receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_002335.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC087721, AK296892, CA394397, D16105
      Consensus CDS
      CCDS10077.1
      UniProtKB/Swiss-Prot
      A6NNJ8, B4DL89, E9PFX4, P29376
      Related
      ENSP00000263800.6, ENST00000263800.11
      Conserved Domains (2) summary
      cd05036
      Location:503 → 779
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam07714
      Location:510 → 777
      Pkinase_Tyr; Protein tyrosine kinase

    3. NM_206961.4 → NP_996844.1  leukocyte tyrosine kinase receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_996844.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is lacking one of the internal coding exons compared to variant 1. This results in an isoform (2) that is missing a 61 aa segment compared to isoform 1.
      Source sequence(s)
      AC016134, AC087721, CA394397, X60702
      Consensus CDS
      CCDS10078.1
      UniProtKB/Swiss-Prot
      P29376
      Related
      ENSP00000347293.5, ENST00000355166.9
      Conserved Domains (2) summary
      cd05036
      Location:442 → 718
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam07714
      Location:449 → 716
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      41503637..41513827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432499.1 → XP_047288455.1  leukocyte tyrosine kinase receptor isoform X2

    2. XM_047432501.1 → XP_047288457.1  leukocyte tyrosine kinase receptor isoform X4

    3. XM_047432502.1 → XP_047288458.1  leukocyte tyrosine kinase receptor isoform X5

    4. XM_047432500.1 → XP_047288456.1  leukocyte tyrosine kinase receptor isoform X3

    5. XM_011521557.3 → XP_011519859.1  leukocyte tyrosine kinase receptor isoform X1

      Conserved Domains (2) summary
      cd05036
      Location:463 → 739
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam07714
      Location:470 → 737
      Pkinase_Tyr; Protein tyrosine kinase

    6. XM_047432505.1 → XP_047288461.1  leukocyte tyrosine kinase receptor isoform X7

    7. XM_024449919.2 → XP_024305687.2  leukocyte tyrosine kinase receptor isoform X6

    8. XM_047432503.1 → XP_047288459.1  leukocyte tyrosine kinase receptor isoform X6

      Related
      ENSP00000458111.1, ENST00000561619.5

    9. XM_047432506.1 → XP_047288462.1  leukocyte tyrosine kinase receptor isoform X8

    RNA

    1. XR_007064446.1 RNA Sequence

    2. XR_007064447.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      39309799..39319984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377906.1 → XP_054233881.1  leukocyte tyrosine kinase receptor isoform X2

    2. XM_054377908.1 → XP_054233883.1  leukocyte tyrosine kinase receptor isoform X4

    3. XM_054377909.1 → XP_054233884.1  leukocyte tyrosine kinase receptor isoform X5

    4. XM_054377907.1 → XP_054233882.1  leukocyte tyrosine kinase receptor isoform X3

    5. XM_054377905.1 → XP_054233880.1  leukocyte tyrosine kinase receptor isoform X1

    6. XM_054377912.1 → XP_054233887.1  leukocyte tyrosine kinase receptor isoform X7

    7. XM_054377911.1 → XP_054233886.1  leukocyte tyrosine kinase receptor isoform X6

    8. XM_054377910.1 → XP_054233885.1  leukocyte tyrosine kinase receptor isoform X6

    9. XM_054377913.1 → XP_054233888.1  leukocyte tyrosine kinase receptor isoform X8

    RNA

    1. XR_008488947.1 RNA Sequence

    2. XR_008488948.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29376.3 GenPept UniProtKB/Swiss-Prot:P29376

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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