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    CTSK cathepsin K [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574112, updated on 5-Mar-2024

    Summary

    Official Symbol
    CTSKprovided by VGNC
    Official Full Name
    cathepsin Kprovided by VGNC
    Primary source
    VGNC:VGNC:71559
    Locus tag
    EGK_01237
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
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    Genomic context

    Location:
    chromosome: 1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (100322705..100335845)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (125257065..125270204, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene cytochrome c-like Neighboring gene aryl hydrocarbon receptor nuclear translocator Neighboring gene U6 spliceosomal RNA Neighboring gene cathepsin S Neighboring gene HORMA domain containing 1 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    cathepsin K
    Names
    cathepsin K preproprotein
    NP_001027984.1
    XP_015005928.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032812.2NP_001027984.1  cathepsin K precursor

      See identical proteins and their annotated locations for NP_001027984.1

      Status: PROVISIONAL

      Source sequence(s)
      AF124092
      UniProtKB/Swiss-Prot
      P61277
      UniProtKB/TrEMBL
      A0A8J8YGW4, G7MDI3, H9FQF5
      Conserved Domains (2) summary
      smart00848
      Location:2685
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      cd02248
      Location:116327
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      100322705..100335845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015150442.2XP_015005928.1  cathepsin K isoform X1

      Conserved Domains (2) summary
      smart00848
      Location:45104
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:134346
      Peptidase_C1; Papain family cysteine protease