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    TPD52 tumor protein D52 [ Homo sapiens (human) ]

    Gene ID: 7163, updated on 7-Apr-2024

    Summary

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    Official Symbol
    TPD52provided by HGNC
    Official Full Name
    tumor protein D52provided by HGNC
    Primary source
    HGNC:HGNC:12005
    See related
    Ensembl:ENSG00000076554 MIM:604068; AllianceGenome:HGNC:12005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    D52; N8L; PC-1; PrLZ; hD52
    Summary
    Enables calcium ion binding activity and protein homodimerization activity. Involved in B cell differentiation. Located in endoplasmic reticulum and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon (RPKM 43.8), prostate (RPKM 36.3) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8q21.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (80031082..80171564, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (80462421..80603125, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (80943317..81083799, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927040 Neighboring gene long intergenic non-protein coding RNA 1607 Neighboring gene U7 small nuclear RNA Neighboring gene RNA, U7 small nuclear 85 pseudogene Neighboring gene Sharpr-MPRA regulatory region 4298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19315 Neighboring gene uncharacterized LOC124901966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19316 Neighboring gene TPD52-MRPS28 readthrough Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene VISTA enhancer hs1305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:80894241-80894806 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:80909347-80909896 Neighboring gene Sharpr-MPRA regulatory region 4480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19317 Neighboring gene Sharpr-MPRA regulatory region 3052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27553 Neighboring gene uncharacterized LOC105375919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19318 Neighboring gene uncharacterized LOC105375918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:81013977-81014477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19319 Neighboring gene uncharacterized LOC105375920 Neighboring gene RNA, 7SL, cytoplasmic 41, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19321 Neighboring gene microRNA 5708

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Circ_0060551 promotes the migration and invasion of cervical cancer by upregulating TPD52. Shi Q, et al. Am J Reprod Immunol, 2022 Sep. PMID 35716110
    2. Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK. Chen Y, et al. Cancer Med, 2023 Jan. PMID 35666017, Free PMC Article
    3. Tissue microarray profiling and integrative proteomics indicate the modulatory potential of Maytenus royleanus in inhibition of overexpressed TPD52 in prostate cancers. Shabbir M, et al. Sci Rep, 2021 Jun 7. PMID 34099820, Free PMC Article
    4. Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer. Fan Y, et al. Autophagy, 2021 Dec. PMID 34034634, Free PMC Article
    5. miR-103a-3p Suppresses Cell Proliferation and Invasion by Targeting Tumor Protein D52 in Prostate Cancer. Ge J, et al. J Invest Surg, 2021 Sep. PMID 32166986

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long noncoding RNA FTX promotes epithelial-mesenchymal transition of epithelial ovarian cancer through modulating miR-7515/TPD52 and activating Met/Akt/mTOR.
      Title: Long noncoding RNA FTX promotes epithelial-mesenchymal transition of epithelial ovarian cancer through modulating miR-7515/TPD52 and activating Met/Akt/mTOR.
    2. Cross talk of tumor protein D52 (TPD52) with KLF9, PKCepsilon, and MicroRNA 223 in ovarian cancer.
      Title: Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer.
    3. Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression.
      Title: Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression.
    4. Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK.
      Title: Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK.
    5. Circ_0060551 promotes the migration and invasion of cervical cancer by upregulating TPD52.
      Title: Circ_0060551 promotes the migration and invasion of cervical cancer by upregulating TPD52.
    6. ERK1/2 inhibits Cullin 3/SPOP-mediated PrLZ ubiquitination and degradation to modulate prostate cancer progression.
      Title: ERK1/2 inhibits Cullin 3/SPOP-mediated PrLZ ubiquitination and degradation to modulate prostate cancer progression.
    7. Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer.
      Title: Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer.
    8. Tissue microarray profiling and integrative proteomics indicate the modulatory potential of Maytenus royleanus in inhibition of overexpressed TPD52 in prostate cancers.
      Title: Tissue microarray profiling and integrative proteomics indicate the modulatory potential of Maytenus royleanus in inhibition of overexpressed TPD52 in prostate cancers.
    9. Exosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis.
      Title: Exosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis.
    10. miR-103a-3p Suppresses Cell Proliferation and Invasion by Targeting Tumor Protein D52 in Prostate Cancer.
      Title: miR-103a-3p Suppresses Cell Proliferation and Invasion by Targeting Tumor Protein D52 in Prostate Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (66)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    EBI GWAS Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    EBI GWAS Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough TPD52-MRPS28

    Readthrough gene: TPD52-MRPS28, Included gene: MRPS28

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in B cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in secretion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor protein D52
    Names
    prostate and colon associated protein
    prostate leucine zipper
    protein N8
    NP_001020423.1
    NP_001020424.1
    NP_001274069.1
    NP_001274071.1
    NP_001274072.1
    NP_001274073.1
    NP_001374708.1
    NP_001374709.1
    NP_005070.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025252.3 → NP_001020423.1  tumor protein D52 isoform 1

      See identical proteins and their annotated locations for NP_001020423.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks two alternate in-frame exons in the central coding region, compared to variant 4, resulting in an isoform (1, also known as PrLZ-224) that is shorter than isoform 4.
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DC383362, GQ499327, U18914
      Consensus CDS
      CCDS34912.1
      UniProtKB/Swiss-Prot
      B7Z414, C9J502, D0UFD1, D0UFD2, D0UFD3, D0UFD4, D0UFD5, E5RKB4, P55327, Q13056, Q53EK8, Q6FGP3, Q6FGS3, Q86YZ2, Q9UCX8
      Related
      ENSP00000368391.3, ENST00000379097.7
      Conserved Domains (1) summary
      pfam04201
      Location:52 → 210
      TPD52; Tumour protein D52 family

    2. NM_001025253.3 → NP_001020424.1  tumor protein D52 isoform 2

      See identical proteins and their annotated locations for NP_001020424.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, compared to variant 4. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 4.
      Source sequence(s)
      AC009686, AK295468, BU071387, CB128067, DA079836, DC331087, U18914
      Consensus CDS
      CCDS47879.1
      UniProtKB/Swiss-Prot
      P55327
      Related
      ENSP00000429915.1, ENST00000518937.6
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 193
      TPD52; Tumour protein D52 family

    3. NM_001287140.2 → NP_001274069.1  tumor protein D52 isoform 4

      See identical proteins and their annotated locations for NP_001274069.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4, also known as PrLZ-247).
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DC383362, GQ499324, U18914
      Consensus CDS
      CCDS75759.1
      UniProtKB/Swiss-Prot
      P55327
      Related
      ENSP00000429309.1, ENST00000520527.5
      Conserved Domains (1) summary
      pfam04201
      Location:52 → 233
      TPD52; Tumour protein D52 family

    4. NM_001287142.2 → NP_001274071.1  tumor protein D52 isoform 5

      See identical proteins and their annotated locations for NP_001274071.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the central coding region, compared to variant 4, resulting in an isoform (5, also known as PrLZ-238) that is shorter than isoform 4.
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DC383362, GQ499325, U18914
      Consensus CDS
      CCDS75757.1
      UniProtKB/Swiss-Prot
      P55327
      Related
      ENSP00000410222.2, ENST00000448733.3
      Conserved Domains (1) summary
      pfam04201
      Location:52 → 224
      TPD52; Tumour protein D52 family

    5. NM_001287143.2 → NP_001274072.1  tumor protein D52 isoform 6

      See identical proteins and their annotated locations for NP_001274072.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon in the central coding region, compared to variant 4, resulting in an isoform (6, also known as PrLZ-233) that is shorter than isoform 4.
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DC383362, GQ499326, U18914
      Consensus CDS
      CCDS75758.1
      UniProtKB/Swiss-Prot
      P55327
      Related
      ENSP00000429351.1, ENST00000517427.5
      Conserved Domains (1) summary
      pfam04201
      Location:52 → 219
      TPD52; Tumour protein D52 family

    6. NM_001287144.2 → NP_001274073.1  tumor protein D52 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, it lacks two alternate in-frame exons in the central coding region, and it uses an alternate splice site that results in an early stop codon, compared to variant 4. The encoded isoform (7) has a distinct N-terminus and is shorter than isoform 4.
      Source sequence(s)
      BU071387, CB128067, DA079836, DA409017, DC331087, U18914
      UniProtKB/Swiss-Prot
      P55327
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 145
      TPD52; Tumour protein D52 family

    7. NM_001387779.1 → NP_001374708.1  tumor protein D52 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC009686
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 146
      TPD52; tumor protein D52 family

    8. NM_001387780.1 → NP_001374709.1  tumor protein D52 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC009686
      Conserved Domains (1) summary
      pfam04201
      Location:20 → 154
      TPD52; tumor protein D52 family

    9. NM_005079.4 → NP_005070.1  tumor protein D52 isoform 3

      See identical proteins and their annotated locations for NP_005070.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, and it lacks two alternate in-frame exons in the central coding region, compared to variant 4. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 4.
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DC331087, U18914
      Consensus CDS
      CCDS55249.1
      UniProtKB/Swiss-Prot
      P55327
      Related
      ENSP00000368390.4, ENST00000379096.9
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 170
      TPD52; tumor protein D52 family

    RNA

    1. NR_105033.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) includes an additional exon in the central region, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 4, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DC383362, GQ499328, U18914

    2. NR_105034.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) contains an alternate 5' terminal exon and lacks three internal exons, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DB505575, DC331087, U18914

    3. NR_105035.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) contains alternate 5' exon structure and lacks two internal exons, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DA199944, DC331087, U18914

    4. NR_105036.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) contains an alternate 5' terminal exon, compared to variant 4. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC009686, AK308983, BU071387, CB128067, DA079836, DA665049, U18914

    5. NR_105037.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) contains alternate 5' exon structure and lacks two internal exons, compared to variant 4. This variant is represented as non-coding because it lacks a supported open reading frame.
      Source sequence(s)
      AC009686, BU071387, CB128067, DA079836, DA665049, DA921955, U18914

    6. NR_170693.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009686

    7. NR_170694.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009686

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      80031082..80171564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      80462421..80603125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55327.2 GenPept UniProtKB/Swiss-Prot:P55327

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