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    Adam12 ADAM metallopeptidase domain 12 [ Mus musculus (house mouse) ]

    Gene ID: 11489, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adam12provided by MGI
    Official Full Name
    ADAM metallopeptidase domain 12provided by MGI
    Primary source
    MGI:MGI:105378
    See related
    Ensembl:ENSMUSG00000054555 AllianceGenome:MGI:105378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mltna
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein that localizes to the cell surface. About a third of the mice lacking the encoded protein die before weaning. Overexpression of the encoded protein in a mouse model of Duchenne muscular dystrophy alleviates the muscle pathology by preventing cell necrosis and inflammation. [provided by RefSeq, May 2016]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 12.7), mammary gland adult (RPKM 6.4) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F3; 7 77.61 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (133484928..133826859, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (133883199..134225097, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20333 Neighboring gene predicted gene 15483 Neighboring gene DEAH-box helicase 32 (putative) Neighboring gene fibronectin type 3 and ankyrin repeat domains 1 Neighboring gene STARR-seq mESC enhancer starr_20336 Neighboring gene STARR-seq mESC enhancer starr_20337 Neighboring gene predicted gene, 51500 Neighboring gene STARR-seq mESC enhancer starr_20338 Neighboring gene predicted gene, 39103 Neighboring gene STARR-seq mESC enhancer starr_20339 Neighboring gene STARR-seq mESC enhancer starr_20340 Neighboring gene STARR-seq mESC enhancer starr_20341 Neighboring gene DNA segment, Chr 7, ERATO Doi 443, expressed Neighboring gene STARR-seq mESC enhancer starr_20343 Neighboring gene predicted gene, 35970 Neighboring gene STARR-seq mESC enhancer starr_20344 Neighboring gene STARR-seq mESC enhancer starr_20345 Neighboring gene STARR-seq mESC enhancer starr_20346 Neighboring gene methionine aminopeptidase 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition. Oh HH, et al. Int J Oncol, 2023 Apr. PMID 36866761, Free PMC Article
    2. ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer. Wang G, et al. Oncoimmunology, 2023. PMID 36545255, Free PMC Article
    3. A disintegrin and metalloproteinase 12 prevents heart failure by regulating cardiac hypertrophy and fibrosis. Nakamura Y, et al. Am J Physiol Heart Circ Physiol, 2020 Feb 1. PMID 31774689
    4. Involvement of ADAM12 in Chondrocyte Differentiation by Regulation of TGF-β1-Induced IGF-1 and RUNX-2 Expressions. Horita M, et al. Calcif Tissue Int, 2019 Jul. PMID 30993375
    5. Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors. Naciri I, et al. Nucleic Acids Res, 2019 Apr 23. PMID 30753595, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy.
      Title: ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy.
    2. A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelialmesenchymal transition.
      Title: A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition.
    3. ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer.
      Title: ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer.
    4. microRNA-29a Regulates ADAM12 Through Direct Interaction With ADAM12 mRNA and Modulates Postischemic Perfusion Recovery.
      Title: microRNA-29a Regulates ADAM12 Through Direct Interaction With ADAM12 mRNA and Modulates Postischemic Perfusion Recovery.
    5. Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth.
      Title: Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth.
    6. Modulation of miR-29a and ADAM12 Reduces Post-Ischemic Skeletal Muscle Injury and Improves Perfusion Recovery and Skeletal Muscle Function in a Mouse Model of Type 2 Diabetes and Peripheral Artery Disease.
      Title: Modulation of miR-29a and ADAM12 Reduces Post-Ischemic Skeletal Muscle Injury and Improves Perfusion Recovery and Skeletal Muscle Function in a Mouse Model of Type 2 Diabetes and Peripheral Artery Disease.
    7. FOXC2/ADAM12-dependent radiosensitivity of head and neck squamous cell carcinoma cells.
      Title: FOXC2/ADAM12-dependent radiosensitivity of head and neck squamous cell carcinoma cells.
    8. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.
      Title: Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.
    9. Involvement of ADAM12 in Chondrocyte Differentiation by Regulation of TGF-beta1-Induced IGF-1 and RUNX-2 Expressions.
      Title: Involvement of ADAM12 in Chondrocyte Differentiation by Regulation of TGF-β1-Induced IGF-1 and RUNX-2 Expressions.
    10. ADAM12 regulates cell proliferation of preadipocytes through IGFBP/IGF/mTOR signaling.
      Title: Knockdown of a disintegrin A metalloprotease 12 (ADAM12) during adipogenesis reduces cell numbers, delays differentiation, and increases lipid accumulation in 3T3-L1 cells.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4001

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 12
    Names
    a disintegrin and metallopeptidase domain 12 (meltrin alpha)
    a disintegrin and metalloprotease domain 12
    a disintegrin and metalloproteinase domain 12 (meltrin alpha)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007400.3 → NP_031426.2  disintegrin and metalloproteinase domain-containing protein 12 preproprotein

      See identical proteins and their annotated locations for NP_031426.2

      Status: VALIDATED

      Source sequence(s)
      AC125372, AC126676, AC140055
      Consensus CDS
      CCDS21938.1
      UniProtKB/Swiss-Prot
      F8VQN4, Q61824
      Related
      ENSMUSP00000065213.5, ENSMUST00000067680.11
      Conserved Domains (7) summary
      smart00050
      Location:437 → 505
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:508 → 650
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:212 → 412
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam14757
      Location:848 → 896
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein
      pfam01421
      Location:212 → 414
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:64 → 161
      Pep_M12B_propep; Reprolysin family propeptide
      pfam16885
      Location:751 → 848
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      133484928..133826859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61824.2 GenPept UniProtKB/Swiss-Prot:Q61824

    Gene LinkOut

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