Tmem175 transmembrane protein 175 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem175provided by MGI
Official Full Name: transmembrane protein 175provided by MGI
Primary source: MGI:MGI:1919642
See related: Ensembl:ENSMUSG00000013495 AllianceGenome:MGI:1919642
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mTMEM175; 3010001K23Rik
Summary: Enables potassium ion leak channel activity. Involved in lysosome organization; neuron cellular homeostasis; and potassium ion transmembrane transport. Predicted to be integral component of endosome membrane and integral component of lysosomal membrane. Predicted to be active in endosome and lysosome. Orthologous to human TMEM175 (transmembrane protein 175). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 32.5), ovary adult (RPKM 20.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 53.24 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (108777649..108795636)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (108629779..108647770)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysosomal K(+) channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease.
Title: Lysosomal K(+) channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease.
Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds.
Title: Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds.
TMEM175 comprises a potassium (K) channel that underlies the molecular mechanism of lysosomal K(+) permeability.
Title: TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (4) 1 citation

General gene information

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Markers

RH135170 (e-PCR)
- UniSTS:218447

AI504381 (e-PCR)
- UniSTS:159411

NoName (e-PCR)
- UniSTS:235249

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonic acid binding	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion leak channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables potassium ion leak channel activity	ISO Inferred from Sequence Orthology more info
enables proton channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lysosomal lumen pH elevation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagosome-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of lysosomal lumen pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lysosomal lumen pH	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endosomal/lysosomal proton channel TMEM175

Names: endosomal/lysomomal potassium channel TMEM175; endosomal/lysosomal potassium channel TMEM175; potassium channel TMEM175

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163531.1 → NP_001157003.1 endosomal/lysosomal proton channel TMEM175 isoform 2

See identical proteins and their annotated locations for NP_001157003.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AK034579, BB653267

UniProtKB/TrEMBL

Q8BM80

Conserved Domains (1) summary

pfam06736
Location:256 → 352

DUF1211; Protein of unknown function (DUF1211)
NM_001163532.1 → NP_001157004.1 endosomal/lysosomal proton channel TMEM175 isoform 1

See identical proteins and their annotated locations for NP_001157004.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1, 3, and 4 all encode the same isoform (1).

Source sequence(s)

AI526594, AK013879, AK034579, BB653267

Consensus CDS

CCDS19514.1

UniProtKB/Swiss-Prot

Q3TDC4, Q99K00, Q9CXY1

Related

ENSMUSP00000068607.7, ENSMUST00000063272.13

Conserved Domains (1) summary

pfam06736
Location:257 → 353

DUF1211; Protein of unknown function (DUF1211)
NM_001359423.1 → NP_001346352.1 endosomal/lysosomal proton channel TMEM175 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).

Source sequence(s)

AC161813

Consensus CDS

CCDS19514.1

UniProtKB/Swiss-Prot

Q3TDC4, Q99K00, Q9CXY1

Related

ENSMUSP00000112780.2, ENSMUST00000120327.3

Conserved Domains (1) summary

pfam06736
Location:257 → 353

DUF1211; Protein of unknown function (DUF1211)
NM_001359426.1 → NP_001346355.1 endosomal/lysosomal proton channel TMEM175 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC161813

Conserved Domains (1) summary

pfam06736
Location:178 → 274

DUF1211; Protein of unknown function (DUF1211)
NM_001359427.1 → NP_001346356.1 endosomal/lysosomal proton channel TMEM175 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC161813, BU057278

Conserved Domains (1) summary

pfam06736
Location:144 → 240

DUF1211; Protein of unknown function (DUF1211)
NM_028223.3 → NP_082499.3 endosomal/lysosomal proton channel TMEM175 isoform 1

See identical proteins and their annotated locations for NP_082499.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1, 3, and 4 all encode the same isoform (1).

Source sequence(s)

AK013879, AK034579, BB653267, BY323049, DN175171

Consensus CDS

CCDS19514.1

UniProtKB/Swiss-Prot

Q3TDC4, Q99K00, Q9CXY1

Related

ENSMUSP00000077437.7, ENSMUST00000078323.13

Conserved Domains (1) summary

pfam06736
Location:257 → 353

DUF1211; Protein of unknown function (DUF1211)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

108777649..108795636

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535230.5 → XP_006535293.1 endosomal/lysosomal proton channel TMEM175 isoform X1

See identical proteins and their annotated locations for XP_006535293.1

UniProtKB/Swiss-Prot

Q3TDC4, Q99K00, Q9CXY1

Conserved Domains (1) summary

pfam06736
Location:257 → 353

DUF1211; Protein of unknown function (DUF1211)
XM_006535232.4 → XP_006535295.1 endosomal/lysosomal proton channel TMEM175 isoform X2

See identical proteins and their annotated locations for XP_006535295.1

Conserved Domains (1) summary

pfam06736
Location:229 → 325

DUF1211; Protein of unknown function (DUF1211)
XM_036165524.1 → XP_036021417.1 endosomal/lysosomal proton channel TMEM175 isoform X3

Conserved Domains (1) summary

pfam06736
Location:144 → 240

DUF1211; Protein of unknown function (DUF1211)
XM_036165526.1 → XP_036021419.1 endosomal/lysosomal proton channel TMEM175 isoform X4

Conserved Domains (1) summary

pfam06736
Location:116 → 212

DUF1211; Protein of unknown function (DUF1211)
XM_006535233.4 → XP_006535296.1 endosomal/lysosomal proton channel TMEM175 isoform X2

See identical proteins and their annotated locations for XP_006535296.1

Conserved Domains (1) summary

pfam06736
Location:229 → 325

DUF1211; Protein of unknown function (DUF1211)
XM_030254826.2 → XP_030110686.1 endosomal/lysosomal proton channel TMEM175 isoform X3

Conserved Domains (1) summary

pfam06736
Location:144 → 240

DUF1211; Protein of unknown function (DUF1211)
XM_030254827.2 → XP_030110687.1 endosomal/lysosomal proton channel TMEM175 isoform X4

Conserved Domains (1) summary

pfam06736
Location:116 → 212

DUF1211; Protein of unknown function (DUF1211)
XM_036165523.1 → XP_036021416.1 endosomal/lysosomal proton channel TMEM175 isoform X1

UniProtKB/Swiss-Prot

Q3TDC4, Q99K00, Q9CXY1

Conserved Domains (1) summary

pfam06736
Location:257 → 353

DUF1211; Protein of unknown function (DUF1211)
XM_006535237.4 → XP_006535300.1 endosomal/lysosomal proton channel TMEM175 isoform X6

UniProtKB/TrEMBL

Q8BHJ8

Conserved Domains (1) summary

pfam06736
Location:32 → 121

DUF1211; Protein of unknown function (DUF1211)
XM_006535236.3 → XP_006535299.1 endosomal/lysosomal proton channel TMEM175 isoform X5

Conserved Domains (1) summary

pfam06736
Location:16 → 112

DUF1211; Protein of unknown function (DUF1211)