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    Ubn1 ubinuclein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302935, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ubn1provided by RGD
    Official Full Name
    ubinuclein 1provided by RGD
    Primary source
    RGD:1311582
    See related
    Ensembl:ENSRNOG00000003019 AllianceGenome:RGD:1311582
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in DNA replication-independent chromatin assembly. Predicted to be located in bicellular tight junction; centriolar satellite; and nuclear body. Predicted to be active in nucleus. Orthologous to human UBN1 (ubinuclein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 211.7), Thymus (RPKM 180.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ubn1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11003036..11038466, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (10496576..10532010, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (10690224..10725655, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SEC14-like lipid binding 5 Neighboring gene periplakin Neighboring gene glyoxylate reductase 1 homolog Neighboring gene rogdi atypical leucine zipper

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors. Aho S, et al. J Cell Biol, 2000 Mar 20. PMID 10725330, Free PMC Article
    2. Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos). Aho S, et al. Biol Cell, 2009 Jun. PMID 18823282
    3. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Tagami H, et al. Cell, 2004 Jan 9. PMID 14718166
    4. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubinuclein-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106977.2 → NP_001100447.2  ubinuclein-1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D4A8C6
      Related
      ENSRNOP00000057947.3, ENSRNOT00000061236.4
      Conserved Domains (2) summary
      pfam08729
      Location:119 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:360 → 573
      UBN_AB; Ubinuclein conserved middle domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      11003036..11038466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245787.5 → XP_006245849.1  ubinuclein-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AM22
      Related
      ENSRNOP00000096576.1
      Conserved Domains (2) summary
      pfam08729
      Location:119 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:360 → 573
      UBN_AB; Ubinuclein conserved middle domain
    Nucleotide Protein Strain
    Heading Accession and Version

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