Kif1a kinesin family member 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif1aprovided by RGD
Official Full Name: kinesin family member 1Aprovided by RGD
Primary source: RGD:1304996
See related: Ensembl:ENSRNOG00000023993 AllianceGenome:RGD:1304996
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables identical protein binding activity and microtubule binding activity. Involved in several processes, including interkinetic nuclear migration; regulation of dendritic spine morphogenesis; and transport along microtubule. Located in several cellular components, including microtubule; neuronal cell body; and secretory vesicle. Is extrinsic component of neuronal dense core vesicle membrane. Part of protein-containing complex. Biomarker of synucleinopathy. Human ortholog(s) of this gene implicated in NESCAV syndrome; hereditary sensory neuropathy; hereditary sensory neuropathy type 2C; hereditary spastic paraplegia; and hereditary spastic paraplegia 30. Orthologous to human KIF1A (kinesin family member 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 766.1) and Adrenal (RPKM 43.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q36

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (101010447..101094891, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (93563033..93647412, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (100171851..100253626, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Specific KIF1A-adaptor interactions control selective cargo recognition.
Title: Specific KIF1A-adaptor interactions control selective cargo recognition.
Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms.
Title: Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms.
A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominant one-head-bound state during its chemomechanical cycle.
Title: A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominant one-head-bound state during its chemomechanical cycle.
The delivery of synaptic vesicle precursors to en passant synapses in hippocampal neurons is specified by an interplay between the kinesin-3 KIF1A motor and presynaptic microtubules. KIF1A binds more weakly to GTP-tubulin than GDP-tubulin and competes with end-binding proteins for binding to the microtubule plus end.
Title: Kinesin-3 Responds to Local Microtubule Dynamics to Target Synaptic Cargo Delivery to the Presynapse.
liprin-alpha and TANC2 are not part of the KIF1A-cargo complex but capture dense core vesicles at dendritic spines.
Title: Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca(2+)/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites.
results suggested that the possibility of stress-induced depressive behavior associated with hippocampal neurodegeneration process is correlated with a low expression of kinesin and dynein, the two most important proteins in axonal transport.
Title: Axonal transport proteins and depressive like behavior, following Chronic Unpredictable Mild Stress in male rat.
The authors found that microtubule-binding protein doublecortin-like kinase 1 (DCLK1) labels a subset of dendritic microtubules and is required for KIF1-dependent dense-core vesicles (DCVs) trafficking into dendrites and dendrite development.
Title: Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites.
Diabetes increased the expression and immunoreactivity of KIF1A and KIF5B in the hippocampus.
Title: Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus.
Pseudorabies virus glycoproteins gE/gI are required for efficient anterograde transport of viral particles in axons by mediating the interaction between Us9 and KIF1A.
Title: Glycoproteins gE and gI are required for efficient KIF1A-dependent anterograde axonal transport of alphaherpesvirus particles in neurons.
While not essential, Us9 phosphorylation enhances Us9-Kif1A-based transport of virions in axons to modulate the overall efficiency of long-distance anterograde spread of infection.
Title: Role of Us9 phosphorylation in axonal sorting and anterograde transport of pseudorabies virus.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

RH125884 (e-PCR)
- UniSTS:162616

AU028841 (e-PCR)
- UniSTS:111937

D29951 (e-PCR)
- UniSTS:124822

D29951 (e-PCR)
- UniSTS:163258

RH139334 (e-PCR)
- UniSTS:221420

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde dendritic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in anterograde dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde neuronal dense core vesicle transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in anterograde synaptic vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in dense core granule cytoskeletal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interkinetic nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in protein transport along microtubule	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde neuronal dense core vesicle transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal dense core vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin-like protein KIF1A

Names: axonal transport of synaptic vesicles-like; neuron-specific kinesin motor KIF1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001408926.1 → NP_001395855.1 kinesin-like protein KIF1A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I5ZRB3

Related

ENSRNOP00000080676.1, ENSRNOT00000106149.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

101010447..101094891 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017596916.3 → XP_017452405.1 kinesin-like protein KIF1A isoform X12
XM_017596915.3 → XP_017452404.1 kinesin-like protein KIF1A isoform X11

UniProtKB/TrEMBL

A0A8I6A6V5, A6JQX4

Related

ENSRNOP00000087220.1

Conserved Domains (8) summary

smart00129
Location:5 → 361

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1578 → 1680

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1583 → 1676

PH; PH domain

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1195 → 1303

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
XM_006245563.5 → XP_006245625.1 kinesin-like protein KIF1A isoform X10

See identical proteins and their annotated locations for XP_006245625.1

UniProtKB/TrEMBL

A0A8L2QJN2

Related

ENSRNOP00000038927.7

Conserved Domains (8) summary

smart00129
Location:5 → 361

KISc; Kinesin motor, catalytic domain. ATPase

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1579 → 1681

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00169
Location:1584 → 1677

PH; PH domain

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1195 → 1304

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
XM_039084755.2 → XP_038940683.1 kinesin-like protein KIF1A isoform X5

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1664 → 1766

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 852

KIF1B; Kinesin protein 1B

pfam12473
Location:1233 → 1389

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
XM_039084756.2 → XP_038940684.1 kinesin-like protein KIF1A isoform X6

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1663 → 1765

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 852

KIF1B; Kinesin protein 1B

pfam12473
Location:1241 → 1388

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
XM_039084754.2 → XP_038940682.1 kinesin-like protein KIF1A isoform X4

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1672 → 1774

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 852

KIF1B; Kinesin protein 1B

pfam12473
Location:1241 → 1397

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
XM_017596914.3 → XP_017452403.1 kinesin-like protein KIF1A isoform X9
XM_017596913.3 → XP_017452402.1 kinesin-like protein KIF1A isoform X8
XM_017596912.3 → XP_017452401.1 kinesin-like protein KIF1A isoform X7

UniProtKB/Swiss-Prot

F1M4A4

Conserved Domains (6) summary

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1588 → 1690

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:814 → 860

KIF1B; Kinesin protein 1B

pfam12473
Location:1157 → 1313

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
XM_039084752.2 → XP_038940680.1 kinesin-like protein KIF1A isoform X3

Conserved Domains (6) summary

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1673 → 1775

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:814 → 861

KIF1B; Kinesin protein 1B

pfam12473
Location:1242 → 1398

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
XM_039084751.2 → XP_038940679.1 kinesin-like protein KIF1A isoform X2

Conserved Domains (6) summary

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1680 → 1782

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:814 → 861

KIF1B; Kinesin protein 1B

pfam12473
Location:1250 → 1405

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
XM_039084750.2 → XP_038940678.1 kinesin-like protein KIF1A isoform X1

Conserved Domains (6) summary

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1681 → 1783

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:814 → 861

KIF1B; Kinesin protein 1B

pfam12473
Location:1250 → 1406

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
XM_063267470.1 → XP_063123540.1 kinesin-like protein KIF1A isoform X1