Cntnap1 contactin associated protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cntnap1provided by RGD
Official Full Name: contactin associated protein 1provided by RGD
Primary source: RGD:70902
See related: Ensembl:ENSRNOG00000020277 AllianceGenome:RGD:70902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Caspr
Summary: Enables SH3 domain binding activity. Predicted to be involved in several processes, including myelination; neuronal action potential propagation; and synapse organization. Predicted to act upstream of or within neuron projection development. Located in paranode region of axon. Is integral component of membrane. Is active in presynaptic active zone membrane. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human CNTNAP1 (contactin associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 247.3), Heart (RPKM 150.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86610140..86625896)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86109850..86125612)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (89087904..89103615)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The physical interaction, co-distribution and functional role of Caspr1-mGlu5R interplay in memory formation was characterized.
Title: Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation.
E. coli exploits Caspr1 as a host receptor for penetration of the blood-brain barrier, resulting in meningitis
Title: Caspr1 is a host receptor for meningitis-causing Escherichia coli.
Caspr1 is a regulator of the trafficking of AMPA receptors to synapses.
Title: Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors.
Caspr labeling was observed through much of the retina, including horizontal, bipolar, amacrine, and ganglion cells.
Title: Localization of the paranodal protein Caspr in the mammalian retina.
The fact that caspr follows the movement of the spiraling membrane has a direct affect on the interpretation of the way in which myelin is formed.
Title: Disposition of axonal caspr with respect to glial cell membranes: Implications for the process of myelination.
Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction.
Title: Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction.
Nogo-A interacts in trans with axonal Caspr at CNS paranodes, an interaction that may have a role in modulating axon-glial junction architecture and possibly K(+)-channel localization during development.
Title: Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE097407 (e-PCR)
- UniSTS:260675

RH140759 (e-PCR)
- UniSTS:222825

BM391105 (e-PCR)
- UniSTS:260731

BE108457 (e-PCR)
- UniSTS:247767

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in central nervous system myelination	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in myelination	TAS Traceable Author Statement more info	PubMed
involved_in myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info
involved_in myelination in peripheral nervous system	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuromuscular junction development, skeletal muscle fiber	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuromuscular process controlling posture	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling posture	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal action potential propagation	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential propagation	ISS Inferred from Sequence or Structural Similarity more info
involved_in paranodal junction assembly	ISO Inferred from Sequence Orthology more info
involved_in paranodal junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in paranodal junction assembly	TAS Traceable Author Statement more info	PubMed
involved_in paranodal junction maintenance	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density organization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
involved_in protein localization to juxtaparanode region of axon	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to paranode region of axon	ISO Inferred from Sequence Orthology more info
involved_in protein localization to paranode region of axon	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synapse maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in paranodal junction	IEA Inferred from Electronic Annotation more info
located_in paranode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in paranode region of axon	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: contactin-associated protein 1

Names: caspr1; neurexin IV; neurexin-4; p190; paranodin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032061.2 → NP_114450.1 contactin-associated protein 1 precursor

See identical proteins and their annotated locations for NP_114450.1

Status: VALIDATED

Source sequence(s)

AF000114, BF393814, CB610334, U87224

UniProtKB/Swiss-Prot

P97846

UniProtKB/TrEMBL

A6HJ93

Related

ENSRNOP00000027505.6, ENSRNOT00000027505.7

Conserved Domains (7) summary

smart00294
Location:1305 → 1323

4.1m; putative band 4.1 homologues' binding motif

smart00231
Location:25 → 169

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

smart00282
Location:1084 → 1219

LamG; Laminin G domain

cd00057
Location:37 → 168

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:176 → 331

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:545 → 574

EGF; EGF-like domain

cl00085
Location:585 → 659

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86610140..86625896

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008768124.4 → XP_008766346.1 contactin-associated protein 1 isoform X3

See identical proteins and their annotated locations for XP_008766346.1

UniProtKB/TrEMBL

A6HJ93

Conserved Domains (6) summary

smart00294
Location:1228 → 1246

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:1007 → 1142

LamG; Laminin G domain

cd00057
Location:1 → 91

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:99 → 254

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:468 → 497

EGF; EGF-like domain

cl00085
Location:508 → 582

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_039086963.2 → XP_038942891.1 contactin-associated protein 1 isoform X4

UniProtKB/TrEMBL

A6HJ93

Conserved Domains (6) summary

smart00294
Location:1217 → 1235

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:996 → 1131

LamG; Laminin G domain

cd00110
Location:88 → 243

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl25480
Location:35 → 80

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00008
Location:457 → 486

EGF; EGF-like domain

cl00085
Location:497 → 571

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_039086962.2 → XP_038942890.1 contactin-associated protein 1 isoform X3

UniProtKB/TrEMBL

A6HJ93

Conserved Domains (6) summary

smart00294
Location:1228 → 1246

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:1007 → 1142

LamG; Laminin G domain

cd00057
Location:1 → 91

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:99 → 254

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:468 → 497

EGF; EGF-like domain

cl00085
Location:508 → 582

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_008768123.4 → XP_008766345.1 contactin-associated protein 1 isoform X3

See identical proteins and their annotated locations for XP_008766345.1

UniProtKB/TrEMBL

A6HJ93

Conserved Domains (6) summary

smart00294
Location:1228 → 1246

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:1007 → 1142

LamG; Laminin G domain

cd00057
Location:1 → 91

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:99 → 254

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:468 → 497

EGF; EGF-like domain

cl00085
Location:508 → 582

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_039086964.2 → XP_038942892.1 contactin-associated protein 1 isoform X4

UniProtKB/TrEMBL

A6HJ93

Conserved Domains (6) summary

smart00294
Location:1217 → 1235

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:996 → 1131

LamG; Laminin G domain

cd00110
Location:88 → 243

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl25480
Location:35 → 80

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00008
Location:457 → 486

EGF; EGF-like domain

cl00085
Location:497 → 571

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_039086960.2 → XP_038942888.1 contactin-associated protein 1 isoform X2

UniProtKB/TrEMBL

A6HJ93

Conserved Domains (6) summary

smart00294
Location:1248 → 1266

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:1027 → 1162

LamG; Laminin G domain

cd00110
Location:119 → 274

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl25480
Location:66 → 111

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00008
Location:488 → 517

EGF; EGF-like domain

cl00085
Location:528 → 602

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_008768122.4 → XP_008766344.1 contactin-associated protein 1 isoform X1

UniProtKB/TrEMBL

A6HJ93

Conserved Domains (7) summary

smart00294
Location:1311 → 1329

4.1m; putative band 4.1 homologues' binding motif

smart00231
Location:25 → 175

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

smart00282
Location:1090 → 1225

LamG; Laminin G domain

cd00057
Location:37 → 174

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:182 → 337

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:551 → 580

EGF; EGF-like domain

cl00085
Location:591 → 665

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_039086961.2 → XP_038942889.1 contactin-associated protein 1 isoform X3

UniProtKB/TrEMBL

A6HJ93

Conserved Domains (6) summary

smart00294
Location:1228 → 1246

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:1007 → 1142

LamG; Laminin G domain

cd00057
Location:1 → 91

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:99 → 254

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:468 → 497

EGF; EGF-like domain

cl00085
Location:508 → 582

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_006247431.5 → XP_006247493.1 contactin-associated protein 1 isoform X3

See identical proteins and their annotated locations for XP_006247493.1

UniProtKB/TrEMBL

A6HJ93

Conserved Domains (6) summary

smart00294
Location:1228 → 1246

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:1007 → 1142

LamG; Laminin G domain

cd00057
Location:1 → 91

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:99 → 254

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:468 → 497

EGF; EGF-like domain

cl00085
Location:508 → 582

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_039086965.2 → XP_038942893.1 contactin-associated protein 1 isoform X4

UniProtKB/TrEMBL

A6HJ93

Conserved Domains (6) summary

smart00294
Location:1217 → 1235

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:996 → 1131

LamG; Laminin G domain

cd00110
Location:88 → 243

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl25480
Location:35 → 80

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00008
Location:457 → 486

EGF; EGF-like domain

cl00085
Location:497 → 571

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_017597555.3 → XP_017453044.1 contactin-associated protein 1 isoform X3

UniProtKB/TrEMBL

A6HJ93

Conserved Domains (6) summary

smart00294
Location:1228 → 1246

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:1007 → 1142

LamG; Laminin G domain

cd00057
Location:1 → 91

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:99 → 254

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:468 → 497

EGF; EGF-like domain

cl00085
Location:508 → 582

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...