Sphk2 sphingosine kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sphk2provided by RGD
Official Full Name: sphingosine kinase 2provided by RGD
Primary source: RGD:1307757
See related: Ensembl:ENSRNOG00000021032 AllianceGenome:RGD:1307757
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable kinase activity; nucleosomal histone binding activity; and sphingosine-1-phosphate receptor activity. Involved in female pregnancy. Predicted to be located in several cellular components, including endoplasmic reticulum; mitochondrial inner membrane; and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Orthologous to human SPHK2 (sphingosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 86.5), Adrenal (RPKM 75.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105317332..105324985, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (96180872..96188592, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101692972..101700604, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hypoxic preconditioning significantly increased SphK2 expression in primary cardiomyocytes
Title: Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway.
Glucose-supported beta-cell growth appears to be in part mediated by SPHK activity.
Title: ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets.
S1P modulates spinal nociceptive processing through inhibition of neuronal cAMP synthesis and sphingosine kinase 1, but not sphingosine kinase 2
Title: Sphingosine 1-phosphate modulates spinal nociceptive processing.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141779 (e-PCR)
- UniSTS:223772

BF415542 (e-PCR)
- UniSTS:248917

RH94402 (e-PCR)
- UniSTS:119650

RH129117 (e-PCR)
- UniSTS:212425

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables D-erythro-sphingosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-erythro-sphingosine kinase activity	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables sphinganine kinase activity	ISO Inferred from Sequence Orthology more info
enables sphingosine-1-phosphate receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to phorbol 13-acetate 12-myristate	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in sphinganine-1-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphinganine-1-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in sphingosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sphingosine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sphingosine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sphingosine kinase 2

NP_001012066.1

EC 2.7.1.91

XP_006229147.1

EC 2.7.1.91

XP_008757605.1

EC 2.7.1.91

XP_038968225.1

EC 2.7.1.91

XP_038968232.1

EC 2.7.1.91

XP_063118198.1

EC 2.7.1.91

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012066.1 → NP_001012066.1 sphingosine kinase 2

See identical proteins and their annotated locations for NP_001012066.1

Status: PROVISIONAL

Source sequence(s)

BC079120

UniProtKB/TrEMBL

A6JB73, F7FEJ8, Q6AYB2

Conserved Domains (1) summary

PLN02958
Location:152 → 607

PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

105317332..105324985 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229085.4 → XP_006229147.1 sphingosine kinase 2 isoform X1

See identical proteins and their annotated locations for XP_006229147.1

UniProtKB/TrEMBL

A6JB73, F7FEJ8, Q6AYB2

Related

ENSRNOP00000028549.4

Conserved Domains (1) summary

PLN02958
Location:152 → 607

PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
XM_008759383.3 → XP_008757605.1 sphingosine kinase 2 isoform X1

See identical proteins and their annotated locations for XP_008757605.1

UniProtKB/TrEMBL

A6JB73, F7FEJ8, Q6AYB2

Conserved Domains (1) summary

PLN02958
Location:152 → 607

PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
XM_039112304.2 → XP_038968232.1 sphingosine kinase 2 isoform X1

UniProtKB/TrEMBL

A6JB73, F7FEJ8, Q6AYB2

Conserved Domains (1) summary

PLN02958
Location:152 → 607

PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
XM_039112297.2 → XP_038968225.1 sphingosine kinase 2 isoform X1

UniProtKB/TrEMBL

A6JB73, F7FEJ8, Q6AYB2

Conserved Domains (1) summary

PLN02958
Location:152 → 607

PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
XM_063262128.1 → XP_063118198.1 sphingosine kinase 2 isoform X1

UniProtKB/TrEMBL

A6JB73, F7FEJ8, Q6AYB2