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    Trmt61a tRNA methyltransferase 61A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314462, updated on 11-Apr-2024

    Summary

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    Symbol
    Trmt61aprovided by RGD
    Full Name
    tRNA methyltransferase 61Aprovided by RGD
    Primary source
    RGD:1359191
    See related
    Ensembl:ENSRNOG00000011398 AllianceGenome:RGD:1359191
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gcd14; Trm61; RGD1359191
    Summary
    Predicted to enable mRNA (adenine-N1-)-methyltransferase activity. Predicted to be involved in mRNA methylation and tRNA methylation. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Orthologous to human TRMT61A (tRNA methyltransferase 61A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 74.2), Brain (RPKM 50.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136558417..136564411)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130737230..130743251)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136150768..136156785)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene carnitine palmitoyltransferase 1A like 1 Neighboring gene microtubule affinity regulating kinase 3 Neighboring gene creatine kinase B Neighboring gene transfer RNA leucine (anticodon AAG) Neighboring gene BAG cochaperone 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Li X, et al. Mol Cell, 2017 Dec 7. PMID 29107537, Free PMC Article
    2. The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Safra M, et al. Nature, 2017 Nov 9. PMID 29072297
    3. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. Ozanick S, et al. RNA, 2005 Aug. PMID 16043508, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94251

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA (adenine-N1-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA (adenine-N1-)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA (adenine(58)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
    Names
    GCD14 and PCMT domain containing protein RGD1359191
    GCD14/PCMT domain containing protein RGD1359191
    mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A
    tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61
    tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A
    tRNA methyltransferase 61 homolog A
    tRNA(m1A58)-methyltransferase subunit TRM61
    tRNA(m1A58)-methyltransferase subunit TRMT61A
    tRNA(m1A58)MTase subunit TRM61
    tRNA(m1A58)MTase subunit TRMT61A
    NP_001007707.1
    XP_008763160.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007706.1 → NP_001007707.1  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

      See identical proteins and their annotated locations for NP_001007707.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079198
      UniProtKB/Swiss-Prot
      Q6AY46
      UniProtKB/TrEMBL
      A6KBS6
      Related
      ENSRNOP00000015308.2, ENSRNOT00000015308.4
      Conserved Domains (3) summary
      COG2519
      Location:9 → 290
      Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
      pfam08704
      Location:64 → 287
      GCD14; tRNA methyltransferase complex GCD14 subunit
      pfam14801
      Location:12 → 58
      GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      136558417..136564411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764938.4 → XP_008763160.1  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A isoform X1

      See identical proteins and their annotated locations for XP_008763160.1

      UniProtKB/Swiss-Prot
      Q6AY46
      UniProtKB/TrEMBL
      A6KBS6
      Conserved Domains (3) summary
      COG2519
      Location:9 → 290
      Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
      pfam08704
      Location:64 → 287
      GCD14; tRNA methyltransferase complex GCD14 subunit
      pfam14801
      Location:12 → 58
      GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY46.1 GenPept UniProtKB/Swiss-Prot:Q6AY46

    Gene LinkOut

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