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    Maml2 mastermind-like transcriptional coactivator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689844, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Maml2provided by RGD
    Official Full Name
    mastermind-like transcriptional coactivator 2provided by RGD
    Primary source
    RGD:1587536
    See related
    Ensembl:ENSRNOG00000005879 AllianceGenome:RGD:1587536
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription of Notch receptor target. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human MAML2 (mastermind like transcriptional coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 80.4), Spleen (RPKM 63.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Maml2 in Genome Data Viewer
    Location:
    8q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (18552480..18869923)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (10268611..10588307)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (11929238..12253991)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene coiled-coil domain containing 82 Neighboring gene JRK-like Neighboring gene uncharacterized LOC134480140 Neighboring gene uncharacterized LOC120094078 Neighboring gene myotubularin related protein 2 Neighboring gene centrosomal protein 57

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Wu L, et al. Mol Cell Biol, 2002 Nov. PMID 12370315, Free PMC Article
    2. Cell and molecular biology of Notch. Fiúza UM, et al. J Endocrinol, 2007 Sep. PMID 17761886
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription of Notch receptor target IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mastermind-like protein 2
    Names
    mastermind like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      18552480..18869923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765997.4 → XP_008764219.2  mastermind-like protein 2 isoform X1

      UniProtKB/TrEMBL
      F1M3B2
      Conserved Domains (1) summary
      pfam09596
      Location:31 → 88
      MamL-1; MamL-1 domain

    2. XM_039082226.2 → XP_038938154.1  mastermind-like protein 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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