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    Ccno cyclin O [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499528, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ccnoprovided by RGD
    Official Full Name
    cyclin Oprovided by RGD
    Primary source
    RGD:1565217
    See related
    Ensembl:ENSRNOG00000010454 AllianceGenome:RGD:1565217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565217
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in response to xenobiotic stimulus. Predicted to be located in nucleolus. Predicted to be part of cyclin A2-CDK2 complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 29. Orthologous to human CCNO (cyclin O). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 37.1), Kidney (RPKM 6.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (46364074..46367113)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (44630873..44633912)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (44857043..44860317)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase 1 Neighboring gene Mtr4 exosome RNA helicase Neighboring gene DExH-box helicase 29 Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene uncharacterized LOC134485840 Neighboring gene uncharacterized LOC134485839

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase. Muller SJ, et al. J Biol Chem, 1993 Jan 15. PMID 8419333
    2. A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer. Gasa L, et al. Sci Rep, 2017 Aug 31. PMID 28860486, Free PMC Article
    3. Expression and activity of the DNA repair enzyme uracil DNA glycosylase during organogenesis in the rat conceptus and following methotrexate exposure in vitro. Vinson RK, et al. Biochem Pharmacol, 2002 Aug 15. PMID 12167490
    4. Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia. Wallmeier J, et al. Nat Genet, 2014 Jun. PMID 24747639
    5. hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup. Kavli B, et al. J Biol Chem, 2002 Oct 18. PMID 12161446

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multi-ciliated epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-O

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399780.1 → NP_001386709.1  cyclin-O

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I5Q4, D3ZHT5
      Related
      ENSRNOP00000013871.6, ENSRNOT00000013871.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      46364074..46367113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001109175.1: Suppressed sequence

      Description
      NM_001109175.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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