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    Lrpap1 LDL receptor related protein associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116565, updated on 5-Mar-2024

    Summary

    Official Symbol
    Lrpap1provided by RGD
    Official Full Name
    LDL receptor related protein associated protein 1provided by RGD
    Primary source
    RGD:620700
    See related
    Ensembl:ENSRNOG00000009313 AllianceGenome:RGD:620700
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables lipase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; negative regulation of amyloid-beta clearance; and negative regulation of very-low-density lipoprotein particle clearance. Located in rough endoplasmic reticulum lumen and vesicle. Used to study membranous glomerulonephritis. Biomarker of membranous glomerulonephritis. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 2281.2), Brain (RPKM 271.5) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Lrpap1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (79876002..79888011)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (75651371..75663380)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (80911281..80923290)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene adrenoceptor alpha 2C Neighboring gene ubiquitin-conjugating enzyme E2 variant 1-like Neighboring gene docking protein 7 Neighboring gene HGF activator

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables low-density lipoprotein particle receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables low-density lipoprotein particle receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables very-low-density lipoprotein particle receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables very-low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cis-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome lumen IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in rough endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in rough endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in rough endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    alpha-2-macroglobulin receptor-associated protein
    Names
    RAP
    alpha-2-MRAP
    gp330-binding 45 kDa protein
    low density lipoprotein receptor-related protein-associated protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169113.1NP_001162584.1  alpha-2-macroglobulin receptor-associated protein precursor

      See identical proteins and their annotated locations for NP_001162584.1

      Status: VALIDATED

      Source sequence(s)
      BC098947, FM055449, M31051
      UniProtKB/Swiss-Prot
      Q4FZX8, Q642A1, Q64723, Q99068
      UniProtKB/TrEMBL
      A6IK06
      Related
      ENSRNOP00000012665.4, ENSRNOT00000012665.6
      Conserved Domains (5) summary
      cd14806
      Location:6170
      RAP_D1; 3-helical coiled coil [structural motif]
      cd14807
      Location:149246
      RAP_D2; Domain 2 of receptor-associated protein (RAP)
      cd14808
      Location:255360
      RAP_D3; C-terminal receptor-associated protein (RAP), Domain 3
      pfam06400
      Location:31134
      Alpha-2-MRAP_N; Alpha-2-macroglobulin RAP, N-terminal domain
      pfam06401
      Location:149360
      Alpha-2-MRAP_C; Alpha-2-macroglobulin RAP, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      79876002..79888011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)