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    Maco1 macoilin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313618, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Maco1provided by RGD
    Official Full Name
    macoilin 1provided by RGD
    Primary source
    RGD:1561685
    See related
    Ensembl:ENSRNOG00000056156 AllianceGenome:RGD:1561685
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem57
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in chemotaxis and neuronal signal transduction. Predicted to act upstream of or within brain development. Predicted to be located in several cellular components, including axon; neuron projection terminus; and synapse. Predicted to be active in nuclear membrane and rough endoplasmic reticulum membrane. Orthologous to human MACO1 (macoilin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 118.1), Adrenal (RPKM 111.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Maco1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (152296107..152358684, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (147012416..147075265, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (153122780..153184940, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor adaptor protein 1 Neighboring gene peptidylprolyl isomerase A, pseudogene 9 Neighboring gene uncharacterized LOC134487008 Neighboring gene Rh blood group, D antigen Neighboring gene transmembrane protein 50A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel and conserved protein macoilin is required for diverse neuronal functions in Caenorhabditis elegans. Miyara A, et al. PLoS Genet, 2011 May. PMID 21589894, Free PMC Article
    2. Entire sequence of a mouse chromosomal segment containing the gene Rhced and a comparative analysis of the homologous human sequence. Kumada M, et al. Gene, 2002 Oct 16. PMID 12459264
    3. Identification of a novel brain-specific and Reelin-regulated gene that encodes a protein colocalized with synapsin. Kuvbachieva A, et al. Eur J Neurosci, 2004 Aug. PMID 15255972
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116145

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuronal signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuronal signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuronal signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in rough endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rough endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rough endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    macoilin
    Names
    transmembrane protein 57

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025699.2 → NP_001020870.2  macoilin

      See identical proteins and their annotated locations for NP_001020870.2

      Status: PROVISIONAL

      Source sequence(s)
      AY845021
      UniProtKB/Swiss-Prot
      Q2TLZ0, Q4V7D3
      Related
      ENSRNOP00000069310.1, ENSRNOT00000079536.2
      Conserved Domains (3) summary
      TIGR03462
      Location:29 → 113
      CarR_dom_SF; lycopene cyclase domain
      pfam09726
      Location:2 → 662
      Macoilin; Transmembrane protein
      pfam16331
      Location:386 → 462
      TolA_bind_tri; TolA binding protein trimerization

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      152296107..152358684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110045.2 → XP_038965973.1  macoilin isoform X1

      UniProtKB/Swiss-Prot
      Q2TLZ0, Q4V7D3
      Conserved Domains (1) summary
      pfam09726
      Location:24 → 611
      Macoilin; Macoilin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V7D3.1 GenPept UniProtKB/Swiss-Prot:Q4V7D3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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