Oxr1 oxidation resistance 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oxr1provided by MGI
Official Full Name: oxidation resistance 1provided by MGI
Primary source: MGI:MGI:2179326
See related: Ensembl:ENSMUSG00000022307 AllianceGenome:MGI:2179326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C7; C7B; 2210416C20Rik
Summary: Enables oxidoreductase activity. Acts upstream of or within several processes, including adult walking behavior; negative regulation of neuron death; and negative regulation of peptidyl-cysteine S-nitrosylation. Located in nucleolus. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Human ortholog(s) of this gene implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Orthologous to human OXR1 (oxidation resistance 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in frontal lobe adult (RPKM 11.8), cerebellum adult (RPKM 10.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 16.06 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (41310745..41724447)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (41447482..41861051)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy.
Title: Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy.
Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson's disease.
Title: Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson's disease.
this study shows that Oxr1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum
Title: Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum.
we present a dysregulation of metabolites of glucose metabolism at the pre-symptomatic stage in the Oxr1 knockout cerebellum. We then demonstrate that Oxr1 and Gpi1 physically and functionally interact and that the level of Gpi1 oligomerisation is disrupted when Oxr1 is deleted in vivo. Furthermore, we show that Oxr1 modulates the additional and less well-understood roles of Gpi1 as a cytokine and neuroprotective factor.
Title: Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase.
screening a panel of proteins that regulate mitochondrial morphology in bella GCs revealed de-regulation of phospho-Drp1(Ser616), a key mitochondrial fission regulatory factor. Our data provide new insights into the function of Oxr1, revealing that specific isoforms of this novel antioxidant protein are associated with mitochondria.
Title: The antioxidant protein Oxr1 influences aspects of mitochondrial morphology.
identify OXR1 as the first neuron-specific antioxidant modulator of pathogenesis and disease progression in SOD1-mediated amyotrophic lateral sclerosis
Title: Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis.
up-regulation of Oxr1 in both human and pre-symptomatic mouse models of amyotrophic lateral sclerosis, indicating that Oxr1 is potentially a novel neuroprotective factor in neurodegenerative disease
Title: Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
The patterns of Oxr1 expression observed suggest that the gene is associated with resistance to hyperoxic challenge and that it acts at the level of the outer segment.
Title: Expression and role of the early-response gene Oxr1 in the hyperoxia-challenged mouse retina.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF407102 (e-PCR)
- UniSTS:248588

AI045087 (e-PCR)
- UniSTS:248384

26.MMHAP87FLA5.seq (e-PCR)
- UniSTS:123759

D15Mit229 (e-PCR), detects polymorphism
- UniSTS:127601

D15Mit24 (e-PCR), detects polymorphism
- UniSTS:127612

D15Mit255 (e-PCR), detects polymorphism
- UniSTS:127626

45.MMHAP36FRG12.seq (e-PCR)
- UniSTS:124578

px-24c4 (e-PCR)
- UniSTS:257450

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to hydroperoxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of peptidyl-cysteine S-nitrosylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: oxidation resistance protein 1

Names: nucleolar protein C7; protein C7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130163.1 → NP_001123635.1 oxidation resistance protein 1 isoform B

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform B) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.

Source sequence(s)

AC129212, AF324899, AF333985, AK158703

Consensus CDS

CCDS49600.1

UniProtKB/Swiss-Prot

Q4KMM3

Related

ENSMUSP00000087553.6, ENSMUST00000090095.13

Conserved Domains (3) summary

smart00584
Location:589 → 751

TLDc; domain in TBC and LysM domain containing proteins

COG1388
Location:12 → 54

LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]

pfam01476
Location:12 → 54

LysM; LysM domain
NM_001130164.1 → NP_001123636.1 oxidation resistance protein 1 isoform C

See identical proteins and their annotated locations for NP_001123636.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform C) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.

Source sequence(s)

AF333985, AK158703, AW106090, BK006239

Consensus CDS

CCDS49601.1

UniProtKB/TrEMBL

B1H3M0

Related

ENSMUSP00000130456.2, ENSMUST00000166917.3

Conserved Domains (1) summary

smart00584
Location:54 → 216

TLDc; domain in TBC and LysM domain containing proteins
NM_001130165.2 → NP_001123637.1 oxidation resistance protein 1 isoform D

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform D) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.

Source sequence(s)

AC129212

Consensus CDS

CCDS49599.1

UniProtKB/TrEMBL

E9Q0A7

Related

ENSMUSP00000126266.2, ENSMUST00000170127.9

Conserved Domains (3) summary

smart00584
Location:670 → 832

TLDc; domain in TBC and LysM domain containing proteins

COG1388
Location:52 → 135

LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]

pfam01476
Location:93 → 135

LysM; LysM domain
NM_001130166.1 → NP_001123638.1 oxidation resistance protein 1 isoform E

See identical proteins and their annotated locations for NP_001123638.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) encodes the longest isoform (E). Variants 5 and 7 encode the same protein.

Source sequence(s)

AF333985, AK158703, BE988908

Consensus CDS

CCDS49598.1

UniProtKB/Swiss-Prot

Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4

Related

ENSMUSP00000105926.3, ENSMUST00000110297.10

Conserved Domains (3) summary

smart00584
Location:704 → 866

TLDc; domain in TBC and LysM domain containing proteins

pfam01476
Location:100 → 142

LysM; LysM domain

cl26761
Location:265 → 549

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
NM_001358976.1 → NP_001345905.1 oxidation resistance protein 1 isoform F

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 5. The encoded isoform (F) has a distinct N-terminus and is shorter than isoform E.

Source sequence(s)

AC129212

Conserved Domains (3) summary

smart00584
Location:697 → 859

TLDc; domain in TBC and LysM domain containing proteins

pfam01476
Location:93 → 135

LysM; LysM domain

pfam09726
Location:257 → 540

Macoilin; Transmembrane protein
NM_001358977.1 → NP_001345906.1 oxidation resistance protein 1 isoform E

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. Variants 5 and 7 encode the same protein.

Source sequence(s)

AC118590, AC129212, AC141481, AC164633

Consensus CDS

CCDS49598.1

UniProtKB/Swiss-Prot

Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4

Conserved Domains (3) summary

smart00584
Location:704 → 866

TLDc; domain in TBC and LysM domain containing proteins

pfam01476
Location:100 → 142

LysM; LysM domain

cl26761
Location:265 → 549

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
NM_001358978.1 → NP_001345907.1 oxidation resistance protein 1 isoform G

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks an exon in the coding region, compared to variant 1. The encoded isoform (G) is shorter, compared to isoform E.

Source sequence(s)

AC118590, AC129212, AC141481, AC164633

Consensus CDS

CCDS88760.1

Related

ENSMUSP00000155237.2, ENSMUST00000230203.2

Conserved Domains (3) summary

smart00584
Location:677 → 839

TLDc; domain in TBC and LysM domain containing proteins

pfam01476
Location:100 → 142

LysM; LysM domain

cl26761
Location:265 → 549

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
NM_130885.2 → NP_570955.1 oxidation resistance protein 1 isoform A

See identical proteins and their annotated locations for NP_570955.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform A) with a shorter and distinct N-terminus, compared to isoform E.

Source sequence(s)

AC129212

Consensus CDS

CCDS27448.1

UniProtKB/Swiss-Prot

Q4KMM3

Related

ENSMUSP00000022918.8, ENSMUST00000022918.15

Conserved Domains (3) summary

smart00584
Location:616 → 778

TLDc; domain in TBC and LysM domain containing proteins

COG1388
Location:12 → 54

LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]

pfam01476
Location:12 → 54

LysM; LysM domain

RNA

NR_152565.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (9) contains an alternate internal exon, compared to variant 5. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC118590, AC129212, AC141481, AC164633

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

41310745..41724447

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159205.1 → XP_036015098.1 oxidation resistance protein 1 isoform X2

Conserved Domains (3) summary

smart00584
Location:690 → 852

TLDc; domain in TBC and LysM domain containing proteins

COG5271
Location:278 → 562

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

pfam01476
Location:113 → 155

LysM; LysM domain
XM_030248362.2 → XP_030104222.1 oxidation resistance protein 1 isoform X4

Conserved Domains (3) summary

smart00584
Location:635 → 797

TLDc; domain in TBC and LysM domain containing proteins

COG5271
Location:196 → 480

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

pfam01476
Location:31 → 73

LysM; LysM domain
XM_036159206.1 → XP_036015099.1 oxidation resistance protein 1 isoform X4

Conserved Domains (3) summary

smart00584
Location:635 → 797

TLDc; domain in TBC and LysM domain containing proteins

COG5271
Location:196 → 480

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

pfam01476
Location:31 → 73

LysM; LysM domain
XM_036159204.1 → XP_036015097.1 oxidation resistance protein 1 isoform X1

Conserved Domains (3) summary

smart00584
Location:717 → 879

TLDc; domain in TBC and LysM domain containing proteins

COG5271
Location:278 → 562

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

pfam01476
Location:113 → 155

LysM; LysM domain
XM_036159207.1 → XP_036015100.1 oxidation resistance protein 1 isoform X5

Conserved Domains (3) summary

smart00584
Location:608 → 770

TLDc; domain in TBC and LysM domain containing proteins

COG5271
Location:196 → 480

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

pfam01476
Location:31 → 73

LysM; LysM domain
XM_036159209.1 → XP_036015102.1 oxidation resistance protein 1 isoform X6

UniProtKB/TrEMBL

A0A2R8W6N3

Related

ENSMUSP00000155161.2, ENSMUST00000230778.2

Conserved Domains (2) summary

COG5271
Location:278 → 562

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

pfam01476
Location:113 → 155

LysM; LysM domain
XM_006520526.5 → XP_006520589.1 oxidation resistance protein 1 isoform X3

Conserved Domains (3) summary

smart00584
Location:637 → 799

TLDc; domain in TBC and LysM domain containing proteins

COG5271
Location:198 → 482

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

pfam01476
Location:33 → 75

LysM; LysM domain
XM_006520531.3 → XP_006520594.1 oxidation resistance protein 1 isoform X7

UniProtKB/TrEMBL

A0A2R8VHT3

Related

ENSMUSP00000155424.2, ENSMUST00000230131.2

Conserved Domains (1) summary

smart00584
Location:81 → 243

TLDc; domain in TBC and LysM domain containing proteins