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    STRADB STE20 related adaptor beta [ Homo sapiens (human) ]

    Gene ID: 55437, updated on 5-Mar-2024

    Summary

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    Official Symbol
    STRADBprovided by HGNC
    Official Full Name
    STE20 related adaptor betaprovided by HGNC
    Primary source
    HGNC:HGNC:13205
    See related
    Ensembl:ENSG00000082146 MIM:607333; AllianceGenome:HGNC:13205
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038
    Summary
    This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 24.2), kidney (RPKM 22.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2q33.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (201451740..201480846)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (201932523..201961624)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (202316463..202345569)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:202153225 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202184683-202185184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202185185-202185684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16990 Neighboring gene trafficking kinesin protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202289002-202289502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202289503-202290003 Neighboring gene SCYL2 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:202315536-202316390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12232 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:202329405-202329904 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:202348230-202348988 Neighboring gene uncharacterized LOC124906113 Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene MPRA-validated peak4010 silencer Neighboring gene MT-CO1 pseudogene 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LKB1-dependent signaling pathways. Alessi DR, et al. Annu Rev Biochem, 2006. PMID 16756488
    2. Emerging roles of pseudokinases. Boudeau J, et al. Trends Cell Biol, 2006 Sep. PMID 16879967
    3. Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase. Nishigaki K, et al. J Biol Chem, 2003 Apr 11. PMID 12574163
    4. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. Boudeau J, et al. EMBO J, 2003 Oct 1. PMID 14517248, Free PMC Article
    5. ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. Sanna MG, et al. J Biol Chem, 2002 Aug 23. PMID 12048196

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a novel XIAP-interacting protein that acts as a co-factor enhancing XIAP-mediated activation of JNK1 and the caspase-independent protection of XIAP against apoptosis
      Title: ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102916

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in aggresome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of serine/threonine protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of serine/threonine protein kinase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    STE20-related kinase adapter protein beta
    Names
    ILP-interacting protein ILPIPA
    STE20-related kinase adaptor beta
    STRAD beta
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein
    pseudokinase ALS2CR2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029572.2 RefSeqGene

      Range
      5002..34108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206864.2 → NP_001193793.1  STE20-related kinase adapter protein beta isoform 2

      See identical proteins and their annotated locations for NP_001193793.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, resulting in a longer transcript and a reading frame-shift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC007282
      Consensus CDS
      CCDS56161.1
      UniProtKB/TrEMBL
      A8K342
      Related
      ENSP00000376080.2, ENST00000392249.6
      Conserved Domains (2) summary
      smart00220
      Location:58 → 369
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08226
      Location:59 → 371
      PK_STRAD_beta; Pseudokinase domain of STE20-related kinase adapter protein beta

    2. NM_018571.6 → NP_061041.2  STE20-related kinase adapter protein beta isoform 1

      See identical proteins and their annotated locations for NP_061041.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC007282
      Consensus CDS
      CCDS2348.1
      UniProtKB/Swiss-Prot
      Q5BKY7, Q9C0K7, Q9P1L0
      UniProtKB/TrEMBL
      A8K342
      Related
      ENSP00000194530.3, ENST00000194530.8
      Conserved Domains (1) summary
      cd08226
      Location:59 → 386
      PK_STRAD_beta; Pseudokinase domain of STE20-related kinase adapter protein beta

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      201451740..201480846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246669.3 → XP_005246726.1  STE20-related kinase adapter protein beta isoform X1

      See identical proteins and their annotated locations for XP_005246726.1

      Conserved Domains (2) summary
      smart00220
      Location:58 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:59 → 276
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      201932523..201961624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342834.1 → XP_054198809.1  STE20-related kinase adapter protein beta isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C0K7.1 GenPept UniProtKB/Swiss-Prot:Q9C0K7

    Gene LinkOut

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