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    Stk17b serine/threonine kinase 17b (apoptosis-inducing) [ Mus musculus (house mouse) ]

    Gene ID: 98267, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Stk17bprovided by MGI
    Official Full Name
    serine/threonine kinase 17b (apoptosis-inducing)provided by MGI
    Primary source
    MGI:MGI:2138162
    See related
    Ensembl:ENSMUSG00000026094 AllianceGenome:MGI:2138162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Drak2; 3110009A03Rik
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of fibroblast apoptotic process; and protein autophosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in actin cytoskeleton. Predicted to be active in nucleus. Is expressed in several structures, including adrenal medulla; alimentary system; central nervous system; immune system; and testis. Orthologous to human STK17B (serine/threonine kinase 17b). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 11.6), thymus adult (RPKM 7.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C1.1; 1 26.99 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (53794671..53824374, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (53755512..53785237, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53553 Neighboring gene solute carrier family 39 (zinc transporter), member 10 pseudogene Neighboring gene dynein, axonemal, heavy chain 7A Neighboring gene STARR-seq mESC enhancer starr_00916 Neighboring gene STARR-seq mESC enhancer starr_00917 Neighboring gene STARR-seq mESC enhancer starr_00918 Neighboring gene STARR-seq mESC enhancer starr_00919 Neighboring gene STARR-seq mESC enhancer starr_00920 Neighboring gene STARR-positive B cell enhancer ABC_E7724 Neighboring gene STARR-seq mESC enhancer starr_00921 Neighboring gene STARR-seq mESC enhancer starr_00924 Neighboring gene predicted gene, 32311 Neighboring gene STARR-positive B cell enhancer ABC_E627 Neighboring gene STARR-positive B cell enhancer ABC_E1544 Neighboring gene STARR-positive B cell enhancer ABC_E3276 Neighboring gene STARR-seq mESC enhancer starr_00925 Neighboring gene STARR-positive B cell enhancer ABC_E7726 Neighboring gene STARR-positive B cell enhancer ABC_E5754 Neighboring gene STARR-seq mESC enhancer starr_00926 Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene microRNA 7681 Neighboring gene predicted gene, 24251

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias. Wu QW, et al. Eur J Neurosci, 2021 Oct. PMID 34536317, Free PMC Article
    2. Drak2 Does Not Regulate TGF-β Signaling in T Cells. Harris TL, et al. PLoS One, 2015. PMID 25951457, Free PMC Article
    3. Drak2 is not required for tumor surveillance and suppression. Edwards BA, et al. Int Immunol, 2015 Mar. PMID 25568303, Free PMC Article
    4. Loss of DRAK2 signaling enhances allogeneic transplant survival by limiting effector and memory T cell responses. Weist BM, et al. Am J Transplant, 2012 Aug. PMID 22494341, Free PMC Article
    5. Drak2 is upstream of p70S6 kinase: its implication in cytokine-induced islet apoptosis, diabetes, and islet transplantation. Mao J, et al. J Immunol, 2009 Apr 15. PMID 19342653

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development.
      Title: DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development.
    2. DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
      Title: DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
    3. Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias.
      Title: Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias.
    4. Data provide insight into the role of Drak2 in autoimmune diseases by showing that Drak2 may not suppress TGF-beta signaling in T cells, and therefore may contribute to autoimmune disease via other molecular pathways.
      Title: Drak2 Does Not Regulate TGF-β Signaling in T Cells.
    5. does not function as an essential tumor suppressor or tumor surveillance protein
      Title: Drak2 is not required for tumor surveillance and suppression.
    6. results demonstrate that DRAK2 plays an important role in primary and memory T cell responsiveness to allografts
      Title: Loss of DRAK2 signaling enhances allogeneic transplant survival by limiting effector and memory T cell responses.
    7. DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation.
      Title: Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.
    8. p70S6 kinase was a bona fide Drak2 substrate
      Title: Drak2 is upstream of p70S6 kinase: its implication in cytokine-induced islet apoptosis, diabetes, and islet transplantation.
    9. Drak2 overexpression led to aggravated beta-cell apoptosis triggered by free fatty acids (FFA) by compromising the increase of anti-apoptotic factors, such as Bcl-2, Bcl-xL and Flip, upon FFA assault
      Title: Drak2 overexpression results in increased beta-cell apoptosis after free fatty acid stimulation.
    10. DRAK2 blockade may lead to permanent autoimmune T cell destruction via intrinsic apoptosis pathways.
      Title: Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 17B
    Names
    DAP kinase-related apoptosis-inducing protein kinase 2
    NP_598571.2
    XP_006496422.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133810.3 → NP_598571.2  serine/threonine-protein kinase 17B

      See identical proteins and their annotated locations for NP_598571.2

      Status: VALIDATED

      Source sequence(s)
      AK165291, AY092028, BY034689
      Consensus CDS
      CCDS14955.1
      UniProtKB/Swiss-Prot
      Q3TNG7, Q8BG48, Q8BLV9, Q923E7
      Related
      ENSMUSP00000027263.8, ENSMUST00000027263.14
      Conserved Domains (2) summary
      smart00220
      Location:37 → 293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14198
      Location:24 → 293
      STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      53794671..53824374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496359.5 → XP_006496422.1  serine/threonine-protein kinase 17B isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 165
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG48.1 GenPept UniProtKB/Swiss-Prot:Q8BG48

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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