U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rps12 ribosomal protein S12 [ Mus musculus (house mouse) ]

    Gene ID: 20042, updated on 3-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rps12provided by MGI
    Official Full Name
    ribosomal protein S12provided by MGI
    Primary source
    MGI:MGI:98105
    See related
    Ensembl:ENSMUSG00000061983 AllianceGenome:MGI:98105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in Golgi apparatus and cytosolic ribosome. Predicted to be part of cytosolic large ribosomal subunit and cytosolic small ribosomal subunit. Orthologous to human RPS12 (ribosomal protein S12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 1796.8), liver E14.5 (RPKM 1660.8) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    10 A4; 10 11.1 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (23661042..23664297, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (23785183..23787383, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35291 Neighboring gene STARR-seq mESC enhancer starr_26047 Neighboring gene nuclear encoded tRNA trytophan 1 (anticodon CCA) Neighboring gene STARR-positive B cell enhancer ABC_E2931 Neighboring gene small nucleolar RNA, C/D box 100 Neighboring gene small nucleolar RNA, H/ACA box 33 Neighboring gene predicted gene, 23130 Neighboring gene STARR-seq mESC enhancer starr_26049 Neighboring gene solute carrier family 18, subfamily B, member 1 Neighboring gene STARR-seq mESC enhancer starr_26051 Neighboring gene STARR-positive B cell enhancer ABC_E8327 Neighboring gene STARR-seq mESC enhancer starr_26053 Neighboring gene vanin 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance. Folgado-Marco V, et al. Elife, 2023 Jun 5. PMID 37272618, Free PMC Article
    2. Cloning and sequencing of mouse ribosomal protein S12 cDNA. Ayane M, et al. Nucleic Acids Res, 1989 Aug 25. PMID 2780296, Free PMC Article
    3. Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts. Raines AM, et al. Development, 2013 Jul. PMID 23760953, Free PMC Article
    4. The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation. Chen N, et al. J Biol Chem, 2008 Jul 25. PMID 18495661, Free PMC Article
    5. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance.
      Title: Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC102111, MGC102112, MGC102499, MGC117504

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in maintenance of translational fidelity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    small ribosomal subunit protein eS12
    Names
    40S ribosomal protein S12

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001407441.1 → NP_001394370.1  small ribosomal subunit protein eS12 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC160147
      UniProtKB/Swiss-Prot
      P09388, P12728, P63323, Q6ZWZ6

    2. NM_001407442.1 → NP_001394371.1  small ribosomal subunit protein eS12 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC160147
      UniProtKB/Swiss-Prot
      P09388, P12728, P63323, Q6ZWZ6
      Related
      ENSMUSP00000151271.2, ENSMUST00000220070.2

    3. NM_001407443.1 → NP_001394372.1  small ribosomal subunit protein eS12 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC160147
      Related
      ENSMUSP00000151586.2, ENSMUST00000218221.2

    4. NM_001407444.1 → NP_001394373.1  small ribosomal subunit protein eS12 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC160147

    5. NM_011295.7 → NP_035425.2  small ribosomal subunit protein eS12 isoform a

      See identical proteins and their annotated locations for NP_035425.2

      Status: VALIDATED

      Source sequence(s)
      AC160147
      Consensus CDS
      CCDS23733.1
      UniProtKB/Swiss-Prot
      P09388, P12728, P63323, Q6ZWZ6
      UniProtKB/TrEMBL
      F7AEH4
      Related
      ENSMUSP00000151305.2, ENSMUST00000218107.2
      Conserved Domains (1) summary
      pfam01248
      Location:16 → 111
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      23661042..23664297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244962.1 → XP_030100822.1  small ribosomal subunit protein eS12 isoform X1

    RNA

    1. XR_003948630.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63323.3 GenPept UniProtKB/Swiss-Prot:P63323

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous