Siglecg sialic acid binding Ig-like lectin G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Siglecgprovided by MGI
Official Full Name: sialic acid binding Ig-like lectin Gprovided by MGI
Primary source: MGI:MGI:2443630
See related: Ensembl:ENSMUSG00000030468 AllianceGenome:MGI:2443630
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Siglec-G; Siglec10; mSiglec-G; 9830164H23; A630096C01Rik
Summary: Predicted to enable SH2 domain binding activity; phosphatase binding activity; and sialic acid binding activity. Involved in several processes, including negative regulation of calcium-mediated signaling; negative regulation of inflammatory response to wounding; and regulation of B cell proliferation. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in thymus primordium. Orthologous to several human genes including SIGLEC10 (sialic acid binding Ig like lectin 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 82.9), mammary gland adult (RPKM 17.6) and 1 other tissue See more
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Genomic context

Location:: 7 B3; 7 28.25 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43057623..43067773)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43408192..43418349)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of Siglec-G on B cells in autoimmune disease and leukemia.
Title: The role of Siglec-G on B cells in autoimmune disease and leukemia.
Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.
Title: Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.
this study shows that Siglec-G inhibits dendritic cells cross-presentation by impairing such complex formation, and our results add insight into the regulation of cross-presentation in adaptive immunity
Title: The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation.
The effect for Siglec-G deficiency in B cells results in higher B-1 cell numbers and a robust and preferential increase in oxidation-specific epitopes-specific IgM antibodies, which neutralize oxidized LDL-induced inflammation in vivo.
Title: Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells.
Aging Siglec-G-deficient and Siglec-G 3/FcgammaRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis.
Title: Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice.
Deficiency of SIGLEC-G was found to increase susceptibility to develop B-cell lymphoproliferative disorders.
Title: SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.
Siglec-G is recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn and the proapoptotic factor BIM that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge.
Title: Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells.
Siglec-G-CD24 axis, controls the severity of GVHD and suggest that enhancing this interaction may represent a novel strategy for mitigating GVHD.
Title: Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice.
Siglec-G sialic acid-dependent binding to the BCR is crucial for the B1 cell-restricted inhibitory function of Siglec-G and is regulated in an opposite way to that of the related protein CD22 (Siglec-2) on B cells.
Title: The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells.
Data indicate that the loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis in MRL/lpr mice.
Title: Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (5) 1 citation
Chemically induced (ENU) (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sialic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables sialic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcium-mediated signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of immunoglobulin production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of inflammatory response to wounding	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of B cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of immune response	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sialic acid-binding Ig-like lectin 10

Names: sialic acid binding Ig-like lectin 10; siglec-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001382486.1 → NP_001369415.1 sialic acid-binding Ig-like lectin 10 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC149091

UniProtKB/TrEMBL

Q8BY18

Conserved Domains (2) summary

cd00096
Location:22 → 26

Ig; Ig strand A [structural motif]

cl11960
Location:22 → 134

Ig; Immunoglobulin domain
NM_172900.4 → NP_766488.2 sialic acid-binding Ig-like lectin 10 isoform 1 precursor

See identical proteins and their annotated locations for NP_766488.2

Status: VALIDATED

Source sequence(s)

AC149091

Consensus CDS

CCDS52221.1

UniProtKB/Swiss-Prot

Q80ZE3

UniProtKB/TrEMBL

Q8BY18

Related

ENSMUSP00000005592.7, ENSMUST00000005592.7

Conserved Domains (3) summary

smart00409
Location:362 → 437

IG; Immunoglobulin

cl11960
Location:22 → 132

Ig; Immunoglobulin domain

cl28434
Location:256 → 335

I-set; Immunoglobulin I-set domain

RNA

NR_175813.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC149091

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

43057623..43067773

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540860.3 → XP_006540923.1 sialic acid-binding Ig-like lectin 10 isoform X1

UniProtKB/TrEMBL

Q8BY18

Conserved Domains (2) summary

smart00409
Location:431 → 506

IG; Immunoglobulin

cl11960
Location:22 → 132

Ig; Immunoglobulin domain