Gpx1 glutathione peroxidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpx1provided by MGI
Official Full Name: glutathione peroxidase 1provided by MGI
Primary source: MGI:MGI:104887
See related: Ensembl:ENSMUSG00000063856 AllianceGenome:MGI:104887
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpx; CGPx; GPx-1; GSHPx-1
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Knockout mice lacking this gene are highly sensitive to oxidants, and develop mature cataracts due to damage to the eye lens nucleus. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Expression: Broad expression in liver adult (RPKM 2481.2), liver E14.5 (RPKM 1548.2) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.24 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108216279..108217541)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108339080..108340342)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPx1 promotes hypertrophic differentiation of chondrocytes through modulation of akt signaling in a non-monotonic manner.
Title: GPx1 promotes hypertrophic differentiation of chondrocytes through modulation of akt signaling in a non-monotonic manner.
Selenium-dependent glutathione peroxidase 1 regulates transcription of elongase 3 in murine tissues.
Title: Selenium-dependent glutathione peroxidase 1 regulates transcription of elongase 3 in murine tissues.
Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction.
Title: Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction.
Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cells.
Title: Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cells.
An adenoviral vector encoded with the GPx-1 gene attenuates memory impairments induced by beta-amyloid (1-42) in GPx-1 KO mice via activation of M1 mAChR-mediated signalling.
Title: An adenoviral vector encoded with the GPx-1 gene attenuates memory impairments induced by β-amyloid (1-42) in GPx-1 KO mice via activation of M1 mAChR-mediated signalling.
CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury.
Title: CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury.
Glutathione Peroxidase-1 Knockout Facilitates Memory Impairment Induced by beta-Amyloid (1-42) in Mice via Inhibition of PKC betaII-Mediated ERK Signaling; Application with Glutathione Peroxidase-1 Gene-Encoded Adenovirus Vector.
Title: Glutathione Peroxidase-1 Knockout Facilitates Memory Impairment Induced by β-Amyloid (1-42) in Mice via Inhibition of PKC βII-Mediated ERK Signaling; Application with Glutathione Peroxidase-1 Gene-Encoded Adenovirus Vector.
Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice.
Title: Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice.
PER1 interaction with GPX1 regulates metabolic homeostasis under oxidative stress.
Title: PER1 interaction with GPX1 regulates metabolic homeostasis under oxidative stress.
Genetic depletion of GPx-1 made animals susceptible to drug dependence induced by cocaine.
Title: Glutathione peroxidase-1 overexpressing transgenic mice are protected from cocaine-induced drug dependence.

Submit: New GeneRIF Correction See all GeneRIFs (93)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI195024 (e-PCR)
- UniSTS:179981

RH124241 (e-PCR)
- UniSTS:161063

NoName (e-PCR)
- UniSTS:532286

Rhoa (e-PCR), detects polymorphism
- UniSTS:532286

Gpx1 (e-PCR), detects polymorphism
- UniSTS:143246

Gpx1 (e-PCR), detects polymorphism
- UniSTS:143247

PMC164851P3 (e-PCR)
- UniSTS:271523

Gpx1 (e-PCR), detects polymorphism
- UniSTS:546806

PMC200187P1 (e-PCR)
- UniSTS:271871

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables glutathione peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid-hydroperoxide glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in UV protection	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis involved in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonic acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within biological process involved in interaction with symbiont	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell redox homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart contraction	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hydrogen peroxide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of intrinsic apoptotic signaling pathway in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoxygenase pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to gamma radiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to hydrogen peroxide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hydroperoxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to selenium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to selenium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to symbiotic bacterium	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within temperature homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with Lewy body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione peroxidase 1

Names: cellular glutathione peroxidase; phospholipid-hydroperoxide glutathione peroxidase GPX1; selenium-dependent glutathione peroxidase 1

NP_001316456.1

EC 1.11.1.12

EC 1.11.1.9

NP_001316457.1

EC 1.11.1.12

EC 1.11.1.9

NP_032186.2

EC 1.11.1.12

EC 1.11.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001329527.1 → NP_001316456.1 glutathione peroxidase 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the 3' terminal exon compared to variant 1. The resulting isoform (2) is 1 amino acid shorter than isoform 1.

Source sequence(s)

BC086649, BY113381, CK628430

UniProtKB/Swiss-Prot

P11352
NM_001329528.1 → NP_001316457.1 glutathione peroxidase 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) is alternatively spliced in the 5' coding region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The resulting isoform (3) has a shorter N-terminus lacking the selenocysteine residue compared to isoform 1.

Source sequence(s)

AW611014, BC086649, CK628430

Consensus CDS

CCDS90662.1

UniProtKB/TrEMBL

A0A0A6YVV2, A0A0A6YY34

Related

ENSMUSP00000141279.2, ENSMUST00000193987.2
NM_008160.6 → NP_032186.2 glutathione peroxidase 1 isoform 1

See identical proteins and their annotated locations for NP_032186.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC086649, CK628430

Consensus CDS

CCDS23522.1

UniProtKB/Swiss-Prot

P11352, P12079, Q544W3, Q5RJH8, Q9CR54

Related

ENSMUSP00000081010.7, ENSMUST00000082429.8

Conserved Domains (1) summary

cd00340
Location:13 → 190

GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...