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    Rplp2 ribosomal protein lateral stalk subunit P2 [ Mus musculus (house mouse) ]

    Gene ID: 67186, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rplp2provided by MGI
    Official Full Name
    ribosomal protein lateral stalk subunit P2provided by MGI
    Primary source
    MGI:MGI:1914436
    See related
    Ensembl:ENSMUSG00000025508 AllianceGenome:MGI:1914436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700049I22Rik
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translational elongation. Located in synapse. Is expressed in several structures, including central nervous system and retina. Orthologous to human RPLP2 (ribosomal protein lateral stalk subunit P2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 465.0), bladder adult (RPKM 400.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F5; 7 86.8 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141027564..141031272)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141447651..141451359)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, glutamate), member 22 Neighboring gene STARR-positive B cell enhancer ABC_E4986 Neighboring gene p53 induced death domain protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1097 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene STARR-positive B cell enhancer ABC_E9305 Neighboring gene patatin-like phospholipase domain containing 2 Neighboring gene calcium release activated channel regulator 2B Neighboring gene predicted gene 10575

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis. Vannella KM, et al. PLoS Pathog, 2014 Sep. PMID 25211233, Free PMC Article
    2. RPLP1, a crucial ribosomal protein for embryonic development of the nervous system. Perucho L, et al. PLoS One, 2014. PMID 24959908, Free PMC Article
    3. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. Yang Y, et al. EMBO J, 2022 Jul 18. PMID 35670107, Free PMC Article
    4. Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. Shu H, et al. Mol Cell Proteomics, 2004 Mar. PMID 14729942
    5. Structure of the human 80S ribosome. Khatter H, et al. Nature, 2015 Apr 30. PMID 25901680

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cytoplasmic translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein P2
    Names
    60S acidic ribosomal protein P2
    ribosomal protein, large P2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360657.1 → NP_001347586.1  large ribosomal subunit protein P2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC158224
      Consensus CDS
      CCDS40187.1
      UniProtKB/Swiss-Prot
      P99027, Q3TKY3, Q9CQ99, Q9CZJ8
      UniProtKB/TrEMBL
      A0A5F8MPY2
      Related
      ENSMUSP00000101625.2, ENSMUST00000106003.2
      Conserved Domains (1) summary
      cd05833
      Location:1 → 66
      Ribosomal_P2; Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins ...

    2. NM_001360658.1 → NP_001347587.1  large ribosomal subunit protein P2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
      Source sequence(s)
      AC158224
      UniProtKB/TrEMBL
      A0A5F8MPY2
      Conserved Domains (1) summary
      cd05833
      Location:1 → 66
      Ribosomal_P2; Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins ...

    3. NM_026020.7 → NP_080296.3  large ribosomal subunit protein P2 isoform a

      See identical proteins and their annotated locations for NP_080296.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC158224
      Consensus CDS
      CCDS40187.1
      UniProtKB/Swiss-Prot
      P99027, Q3TKY3, Q9CQ99, Q9CZJ8
      UniProtKB/TrEMBL
      A0A5F8MPY2
      Related
      ENSMUSP00000081474.5, ENSMUST00000084434.11
      Conserved Domains (1) summary
      cd05833
      Location:1 → 66
      Ribosomal_P2; Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141027564..141031272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P99027.3 GenPept UniProtKB/Swiss-Prot:P99027

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