Ahsg alpha-2-HS-glycoprotein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ahsgprovided by MGI
Official Full Name: alpha-2-HS-glycoproteinprovided by MGI
Primary source: MGI:MGI:107189
See related: Ensembl:ENSMUSG00000022868 AllianceGenome:MGI:107189
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable endopeptidase inhibitor activity and receptor signaling protein tyrosine kinase inhibitor activity. Involved in negative regulation of bone mineralization. Acts upstream of or within ossification. Predicted to be located in Golgi apparatus; collagen-containing extracellular matrix; and extracellular space. Predicted to be part of protein-containing complex. Predicted to be active in extracellular matrix and extracellular region. Is expressed in several structures, including gut; heart; limb segment; reproductive system; and skeletal musculature. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 1; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human AHSG (alpha 2-HS glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 13022.2), liver adult (RPKM 6468.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 16 B1; 16 13.74 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (22710793..22718193)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (22892015..22899451)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exogenous fetuin-A protects against sepsis-induced myocardial injury by inhibiting oxidative stress and inflammation in mice.
Title: Exogenous fetuin-A protects against sepsis-induced myocardial injury by inhibiting oxidative stress and inflammation in mice.
FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells through TLR4-NFkB pathway.
Title: FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells through TLR4-NFkB pathway.
Blocking TLR4-NF-kappaB pathway protects mouse islets from the combinatorial impact of high fat and fetuin-A mediated dysfunction and restores ability for insulin secretion.
Title: Blocking TLR4-NF-κB pathway protects mouse islets from the combinatorial impact of high fat and fetuin-A mediated dysfunction and restores ability for insulin secretion.
Fetuin-A secretion from beta-cells leads to accumulation of macrophages in islets, aggravates inflammation and impairs insulin secretion.
Title: Fetuin-A secretion from β-cells leads to accumulation of macrophages in islets, aggravates inflammation and impairs insulin secretion.
Increase in PPARgamma inhibitory phosphorylation by Fetuin-A through the activation of Ras-MEK-ERK pathway causes insulin resistance.
Title: Increase in PPARγ inhibitory phosphorylation by Fetuin-A through the activation of Ras-MEK-ERK pathway causes insulin resistance.
Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress.
Title: Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress.
Acute Anti-Inflammatory Markers ITIH4 and AHSG in Mice Brain of a Novel Alzheimer's Disease Model.
Title: Acute Anti-Inflammatory Markers ITIH4 and AHSG in Mice Brain of a Novel Alzheimer's Disease Model.
Soft tissue calcification can start by intravascular mineral deposition causing microvasculopathy in Ahsg -/- mouse, which impacts on growth, organ function and survival.
Title: Lumenal calcification and microvasculopathy in fetuin-A-deficient mice lead to multiple organ morbidity.
Fetuin-A mediates hepatotoxicity of acetaminophen-induced liver injury through infiltration of monocytes into the liver.
Title: Hepatic upregulation of fetuin-A mediates acetaminophen-induced liver injury through activation of TLR4 in mice.
Other HBPs such as alpha 2-HS glycoprotein (AHSG) and histidine-rich glycoprotein (HRG) need further investigation for potential applications in the management of Acute pancreatitis (AP) . Pancreas HBPs are extracellular and so easily accessible and are potential drug targets in AP, whereas plasma HBPs represent potential biomarkers for AP.
Title: The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237473

Ahsg (e-PCR), detects polymorphism
- UniSTS:233941

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor signaling protein tyrosine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute-phase response	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ossification	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-2-HS-glycoprotein

Names: countertrypin; fetuin-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276449.2 → NP_001263378.1 alpha-2-HS-glycoprotein isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CT027991

Conserved Domains (1) summary

smart00043
Location:26 → 96

CY; Cystatin-like domain
NM_001276450.2 → NP_001263379.1 alpha-2-HS-glycoprotein isoform 3 precursor

Status: VALIDATED

Source sequence(s)

CT027991

UniProtKB/TrEMBL

Q3TIU3, Q3UEK5

Conserved Domains (2) summary

smart00043
Location:26 → 126

CY; Cystatin-like domain

pfam00031
Location:142 → 230

Cystatin; Cystatin domain
NM_013465.3 → NP_038493.1 alpha-2-HS-glycoprotein isoform 1 precursor

See identical proteins and their annotated locations for NP_038493.1

Status: VALIDATED

Source sequence(s)

CT027991

Consensus CDS

CCDS28071.1

UniProtKB/Swiss-Prot

O35634, P29699

UniProtKB/TrEMBL

Q3TIU3, Q3UEK5, Q3UEK9

Related

ENSMUSP00000023583.6, ENSMUST00000023583.7

Conserved Domains (2) summary

smart00043
Location:26 → 133

CY; Cystatin-like domain

pfam00031
Location:149 → 239

Cystatin; Cystatin domain