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    HAT1 histone acetyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 8520, updated on 5-Mar-2024

    Summary

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    Official Symbol
    HAT1provided by HGNC
    Official Full Name
    histone acetyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:4821
    See related
    Ensembl:ENSG00000128708 MIM:603053; AllianceGenome:HGNC:4821
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAT1
    Summary
    The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]
    Expression
    Ubiquitous expression in lymph node (RPKM 13.0), bone marrow (RPKM 11.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2q31.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (171922461..171983686)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (172400272..172469906)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (172778971..172848600)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373739 Neighboring gene uncharacterized LOC105373740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:172778407-172779055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16760 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:172791325-172791562 Neighboring gene VISTA enhancer hs646 Neighboring gene PDGFA associated protein 1 pseudogene Neighboring gene uncharacterized LOC124905590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12106 Neighboring gene methionyl aminopeptidase type 1D, mitochondrial Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16761 Neighboring gene VISTA enhancer hs553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:172945060-172945588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:172945589-172946118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:172948655-172949268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:172949269-172949880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:172949881-172950494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:172950495-172951106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:172951721-172952332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:172952946-172953557 Neighboring gene distal-less homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease. Ortega MA, et al. Genes (Basel), 2023 Apr 14. PMID 37107673, Free PMC Article
    2. HAT1: Landscape of Biological Function and Role in Cancer. Capone V, et al. Cells, 2023 Apr 2. PMID 37048148, Free PMC Article
    3. Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis. Yang G, et al. EMBO Rep, 2021 Feb 3. PMID 33372411, Free PMC Article
    4. HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding. Gruber JJ, et al. Mol Cell, 2019 Aug 22. PMID 31278053, Free PMC Article
    5. Histone acetyltransferase 1 up regulates Bcl2L12 expression in nasopharyngeal cancer cells. Miao BP, et al. Arch Biochem Biophys, 2018 May 15. PMID 29621521

    See all (140) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma.
      Title: HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma.
    2. Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
      Title: Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
    3. Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease.
      Title: Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease.
    4. HAT1: Landscape of Biological Function and Role in Cancer.
      Title: HAT1: Landscape of Biological Function and Role in Cancer.
    5. FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer.
      Title: FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer.
    6. Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.
      Title: Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.
    7. Proteomic analysis identifies novel binding partners of BAP1.
      Title: Proteomic analysis identifies novel binding partners of BAP1.
    8. Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis.
      Title: Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis.
    9. these data describe a feedforward circuit whereby HAT1 captures acetyl groups on nascent histones and drives H4 production by chromatin binding to support chromatin replication and acetylation.
      Title: HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding.
    10. High HAT1 expression is associated with Pancreatic ductal adenocarcinoma.
      Title: Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
    Vpr vpr HIV-1 Vpr forms a complex by recruiting RbAp46, HAT1, ZIP/sZIP, and Cul4A PubMed
    vpr HIV-1 Vpr is identified to have a physical interaction with histone acetyltransferase 1 (HAT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone H4 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4K12 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in internal protein amino acid acetylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, telomeric region HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone acetyltransferase type B catalytic subunit
    NP_003633.2
    XP_006712871.1
    XP_054188848.1
    XP_054200225.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003642.4 → NP_003633.2  histone acetyltransferase type B catalytic subunit

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AC114745
      Consensus CDS
      CCDS2245.1
      UniProtKB/Swiss-Prot
      O14929, Q49A44, Q53QF0, Q53SU4, Q6P594, Q8WWB9
      Related
      ENSP00000264108.4, ENST00000264108.5
      Conserved Domains (1) summary
      pfam10394
      Location:25 → 187
      Hat1_N; Histone acetyl transferase HAT1 N-terminus

    RNA

    1. NR_027862.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC114745
      Related
      ENST00000412731.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      171922461..171983686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712808.4 → XP_006712871.1  histone acetyltransferase type B catalytic subunit isoform X1

      See identical proteins and their annotated locations for XP_006712871.1

      Conserved Domains (1) summary
      pfam10394
      Location:19 → 181
      Hat1_N; Histone acetyl transferase HAT1 N-terminus

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791761.1 Reference GRCh38.p14 PATCHES

      Range
      353079..422730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332873.1 → XP_054188848.1  histone acetyltransferase type B catalytic subunit isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      172400272..172469906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344250.1 → XP_054200225.1  histone acetyltransferase type B catalytic subunit isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033085.1: Suppressed sequence

      Description
      NM_001033085.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14929.2 GenPept UniProtKB/Swiss-Prot:O14929

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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