MSR1 macrophage scavenger receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MSR1provided by HGNC
Official Full Name: macrophage scavenger receptor 1provided by HGNC
Primary source: HGNC:HGNC:7376
See related: Ensembl:ENSG00000038945 MIM:153622; AllianceGenome:HGNC:7376
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SRA; SR-A; CD204; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII
Summary: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lung (RPKM 26.5), gall bladder (RPKM 9.7) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (16107881..16192651, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (16374329..16459913, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (15965390..16050160, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of macrophage scavenger receptor 1 in the progression of dyslipidemia in acne vulgaris patients.
Title: Role of macrophage scavenger receptor 1 in the progression of dyslipidemia in acne vulgaris patients.
Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen.
Title: Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen.
Scavenger receptor a mediates glycated LDL transcytosis across endothelial cells to promote atherosclerosis.
Title: Scavenger receptor a mediates glycated LDL transcytosis across endothelial cells to promote atherosclerosis.
Comprehensive analysis of immune cell infiltration and role of MSR1 expression in aneurysmal subarachnoid haemorrhage.
Title: Comprehensive analysis of immune cell infiltration and role of MSR1 expression in aneurysmal subarachnoid haemorrhage.
Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis.
Title: Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis.
MSR1 characterized by chromatin accessibility mediates M2 macrophage polarization to promote gastric cancer progression.
Title: MSR1 characterized by chromatin accessibility mediates M2 macrophage polarization to promote gastric cancer progression.
Comprehensive analysis of the prognostic and role in immune cell infiltration of MSR1 expression in lower-grade gliomas.
Title: Comprehensive analysis of the prognostic and role in immune cell infiltration of MSR1 expression in lower-grade gliomas.
MSR1 and NEP Are Correlated with Alzheimer's Disease Amyloid Pathology and Apolipoprotein Alterations.
Title: MSR1 and NEP Are Correlated with Alzheimer's Disease Amyloid Pathology and Apolipoprotein Alterations.
Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.
Title: Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.
CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer.
Title: CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer.

Submit: New GeneRIF Correction See all GeneRIFs (100)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Barrett esophagus MedGen: C0004763 OMIM: 614266 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH17755 (e-PCR)
- UniSTS:91415

SHGC-12479 (e-PCR)
- UniSTS:17702

PMC310830P18 (e-PCR)
- UniSTS:272763

PMC310830P19 (e-PCR)
- UniSTS:272764

PMC310830P21 (e-PCR)
- UniSTS:272766

RH47928 (e-PCR)
- UniSTS:47745

NoName (e-PCR)
- UniSTS:481933

GDB:580807 (e-PCR)
- UniSTS:157850

D8S1193 (e-PCR)
- UniSTS:150233

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	ISS Inferred from Sequence or Structural Similarity more info
enables cargo receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables low-density lipoprotein particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scavenger receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in cholesterol transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cholesterol storage	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
part_of low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: macrophage scavenger receptor types I and II

Names: macrophage acetylated LDL receptor I and II; macrophage scavenger receptor type III; scavenger receptor class A member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012102.1 RefSeqGene

Range

5141..89911

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001363744.1 → NP_001350673.1 macrophage scavenger receptor types I and II isoform 4

Status: REVIEWED

Source sequence(s)

AC023396, AK293217, BC063878

Consensus CDS

CCDS87581.1

UniProtKB/TrEMBL

B4DDJ5

Related

ENSP00000405453.2, ENST00000445506.6

Conserved Domains (4) summary

pfam01391
Location:298 → 352

Collagen; Collagen triple helix repeat (20 copies)

smart00202
Location:368 → 468

SR; Scavenger receptor Cys-rich

pfam03523
Location:139 → 187

Macscav_rec; Macrophage scavenger receptor

cl26252
Location:122 → 287

AAA_13; AAA domain
NM_002445.4 → NP_002436.1 macrophage scavenger receptor types I and II isoform type 2

See identical proteins and their annotated locations for NP_002436.1

Status: REVIEWED

Description

Transcript Variant: This variant (SR-AII), also known as phSR2, uses two alternative exons and also lacks two downstream exons compared to variant SR-AI. These differences causes an alternate 3' end in the coding region, and has a distinct 3' UTR. It encodes isoform type 2 that is shorter and has a different C-terminus than isoform type 1.

Source sequence(s)

AC023396, D90188

Consensus CDS

CCDS5997.1

UniProtKB/Swiss-Prot

P21757

Related

ENSP00000371428.4, ENST00000381998.8

Conserved Domains (2) summary

pfam01391
Location:280 → 334

Collagen; Collagen triple helix repeat (20 copies)

pfam03523
Location:121 → 169

Macscav_rec; Macrophage scavenger receptor
NM_138715.3 → NP_619729.1 macrophage scavenger receptor types I and II isoform type 1

See identical proteins and their annotated locations for NP_619729.1

Status: REVIEWED

Description

Transcript Variant: This variant (SR-AI), also known as phSR1, encodes the longest isoform.

Source sequence(s)

AC023396, D90187, DA995755

Consensus CDS

CCDS5995.1

UniProtKB/Swiss-Prot

D3DSP3, O60505, P21757, P21759, Q45F10

Related

ENSP00000262101.5, ENST00000262101.10

Conserved Domains (4) summary

pfam01391
Location:280 → 334

Collagen; Collagen triple helix repeat (20 copies)

smart00202
Location:350 → 450

SR; Scavenger receptor Cys-rich

pfam03523
Location:121 → 169

Macscav_rec; Macrophage scavenger receptor

cl26252
Location:104 → 269

AAA_13; AAA domain
NM_138716.3 → NP_619730.1 macrophage scavenger receptor types I and II isoform type 3

See identical proteins and their annotated locations for NP_619730.1

Status: REVIEWED

Description

Transcript Variant: This variant (SR-AIII) lacks an exon in the coding region, but maintains the same reading frame, as compared to variant SR-AI. It encodes an isoform type 3 that lacks 63 internal amino acids compared to isoform type 1.

Source sequence(s)

AC023396, D90187, DA995755

Consensus CDS

CCDS5996.1

UniProtKB/Swiss-Prot

P21757

Related

ENSP00000262100.3, ENST00000350896.3

Conserved Domains (4) summary

pfam01391
Location:280 → 334

Collagen; Collagen triple helix repeat (20 copies)

smart00202
Location:346 → 387

SR; Scavenger receptor Cys-rich

pfam00530
Location:318 → 387

SRCR; Scavenger receptor cysteine-rich domain

pfam03523
Location:121 → 169

Macscav_rec; Macrophage scavenger receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

16107881..16192651 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024447161.2 → XP_024302929.1 macrophage scavenger receptor types I and II isoform X1

Conserved Domains (3) summary

pfam01391
Location:298 → 352

Collagen; Collagen triple helix repeat (20 copies)

pfam03523
Location:139 → 187

Macscav_rec; Macrophage scavenger receptor

cl26252
Location:122 → 287

AAA_13; AAA domain