VAT1 vesicle amine transport 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: VAT1provided by HGNC
Official Full Name: vesicle amine transport 1provided by HGNC
Primary source: HGNC:HGNC:16919
See related: Ensembl:ENSG00000108828 MIM:604631; AllianceGenome:HGNC:16919
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: VATI
Summary: Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in adrenal (RPKM 107.1), ovary (RPKM 104.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.31

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (43014607..43022385, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (43871891..43880260, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (41166624..41174402, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein.
Title: Identification and Characterization of Synaptic Vesicle Membrane Protein VAT-1 Homolog as a New Catechin-Binding Protein.
Structural insights into vesicle amine transport-1 (VAT-1) as a member of the NADPH-dependent quinone oxidoreductase family.
Title: Structural insights into vesicle amine transport-1 (VAT-1) as a member of the NADPH-dependent quinone oxidoreductase family.
Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas.
Title: Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas.
Structural basis for interorganelle phospholipid transport mediated by VAT-1.
Title: Structural basis for interorganelle phospholipid transport mediated by VAT-1.
We demonstrate that VAT-1 is a novel pathogenic factor in benign prostatic hyperplasia associated with cell proliferation.
Title: VAT-1 is a novel pathogenic factor of progressive benign prostatic hyperplasia.
The role of phospholipase D in the transport of VAT1 to plasma membranes and in phosphatidic acid metabolism in neutrophils is reported.
Title: An essential role for phospholipase D in the recruitment of vesicle amine transport protein-1 to membranes in human neutrophils.
VAT-1 is overexpressed in glioblastomas and functionally involved in glioma cell migration, representing a new component involved in glioma invasion
Title: Vesicle amine transport protein-1 (VAT-1) is upregulated in glioblastomas and promotes migration.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Expression of HIV-1 Tat upregulates the abundance of vesicle amine transport protein 1 homolog (VAT1) in the nucleoli of Jurkat T-cells	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of vesicle amine transport 1 (VAT1) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-AA025690 (e-PCR)
- UniSTS:43578

A002O37 (e-PCR)
- UniSTS:61757

G30666 (e-PCR)
- UniSTS:39512

RH79132 (e-PCR)
- UniSTS:23905

HSC1IB122 (e-PCR)
- UniSTS:2505

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in azurophil granule lumen	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: synaptic vesicle membrane protein VAT-1 homolog

Names: membrane protein of cholinergic synaptic vesicles; vesicle amine transport protein 1 homolog (T. californica)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006373.4 → NP_006364.2 synaptic vesicle membrane protein VAT-1 homolog

See identical proteins and their annotated locations for NP_006364.2

Status: VALIDATED

Source sequence(s)

AC055866, AC135721

Consensus CDS

CCDS11451.1

UniProtKB/Swiss-Prot

A8K345, B0AZP7, B4DPX4, Q13035, Q5BKZ7, Q96A39, Q99536, Q9BUT8

Related

ENSP00000347872.2, ENST00000355653.8

Conserved Domains (2) summary

cd08275
Location:49 → 387

MDR3; Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family

COG0604
Location:51 → 387

Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]