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    SFXN1 sideroflexin 1 [ Homo sapiens (human) ]

    Gene ID: 94081, updated on 4-Jul-2021

    Summary

    Official Symbol
    SFXN1provided by HGNC
    Official Full Name
    sideroflexin 1provided by HGNC
    Primary source
    HGNC:HGNC:16085
    See related
    Ensembl:ENSG00000164466 MIM:615569
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCC; SLC56A1
    Expression
    Ubiquitous expression in liver (RPKM 20.2), kidney (RPKM 17.3) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SFXN1 in Genome Data Viewer
    Location:
    5q35.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (175478560..175529742)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (174905563..174956745)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 2 binding protein pseudogene 6 Neighboring gene dopamine receptor D1 Neighboring gene RN7SK pseudogene 148 Neighboring gene uncharacterized LOC105377743 Neighboring gene Sharpr-MPRA regulatory region 12912 Neighboring gene histamine receptor H2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify sideroflexin 1 (SFXN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify sideroflexin 1 (SFXN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify sideroflexin 1 (SFXN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify sideroflexin 1 (SFXN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12876

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables D-serine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-serine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in D-serine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-serine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of one-carbon metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in serine import into mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in serine import into mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in integral component of mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    sideroflexin-1
    Names
    tricarboxylate carrier protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322977.2NP_001309906.1  sideroflexin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC091393
      Consensus CDS
      CCDS4394.1
      UniProtKB/Swiss-Prot
      Q9H9B4
      Conserved Domains (1) summary
      pfam03820
      Location:10322
      Mtc; Tricarboxylate carrier
    2. NM_001322978.2NP_001309907.1  sideroflexin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC091393
      Conserved Domains (1) summary
      pfam03820
      Location:2261
      Mtc; Tricarboxylate carrier
    3. NM_001322980.2NP_001309909.1  sideroflexin-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC091393
    4. NM_001322981.2NP_001309910.1  sideroflexin-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC091393
    5. NM_001322982.2NP_001309911.1  sideroflexin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC091393
      Conserved Domains (1) summary
      pfam03820
      Location:2261
      Mtc; Tricarboxylate carrier
    6. NM_001322983.2NP_001309912.1  sideroflexin-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC091393
      Conserved Domains (1) summary
      pfam03820
      Location:10241
      Mtc; Tricarboxylate carrier
    7. NM_022754.7NP_073591.2  sideroflexin-1 isoform 1

      See identical proteins and their annotated locations for NP_073591.2

      Status: VALIDATED

      Source sequence(s)
      AC091393, AK022938, BC063241, BP199230, BU689165, CN480623
      Consensus CDS
      CCDS4394.1
      UniProtKB/Swiss-Prot
      Q9H9B4
      Related
      ENSP00000316905.5, ENST00000321442.10
      Conserved Domains (1) summary
      pfam03820
      Location:10322
      Mtc; Tricarboxylate carrier

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      175478560..175529742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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